Increased white matter hyperintensities in male methamphetamine abusers

The current study was conducted to compare the prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance (MR) imaging in methamphetamine (MA) abusers. Thirty-three MA abusers and 32 age- and gender-matched healthy comparison subjects were studied. A...

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Vydáno v:Drug and alcohol dependence Ročník 81; číslo 1; s. 83 - 88
Hlavní autoři: Bae, Soojeong C., Lyoo, In Kyoon, Sung, Young Hoon, Yoo, Jaeun, Chung, Ain, Yoon, Su-Jung, Kim, Dai-Jin, Hwang, Jaeuk, Kim, Seog Ju, Renshaw, Perry F.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Shannon Elsevier Ireland Ltd 04.01.2006
Elsevier Science
Témata:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Amphetamine-Related Disorders - pathology
Biological and medical sciences
Brain - pathology
Brain activity
Brain imaging
Brain magnetic resonance imaging
Cerebral Ventricles - pathology
Dementia, Vascular - chemically induced
Dementia, Vascular - pathology
Demyelinating Diseases - chemically induced
Demyelinating Diseases - pathology
Dose-Response Relationship, Drug
Drug abusers
Drug addiction
Gender difference
Gender differences
Humans
Korea
Magnetic Resonance Imaging
Male
Medical sciences
Methamphetamine
Methamphetamine - toxicity
Midline Thalamic Nuclei - pathology
Neuropharmacology
Neurotoxicity Syndromes - pathology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Reference Values
Risk Factors
Statistics as Topic
Toxicology
White matter hyperintensities
Korea
White matter hyperintensities
Brain magnetic resonance imaging
Methamphetamine
Gender difference
Amphetamine derivatives
Human
Brain
Drug addiction
CNS stimulant
Psychotropic
Central nervous system
Metamfetamine
Sex
Male
Sympathomimetic
Nuclear magnetic resonance imaging
White matter
Encephalon
Addiction
Methamphetamine: White matter hyperintensities
Medical imagery
Psychiatry
ISSN:0376-8716, 1879-0046
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Shrnutí:The current study was conducted to compare the prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance (MR) imaging in methamphetamine (MA) abusers. Thirty-three MA abusers and 32 age- and gender-matched healthy comparison subjects were studied. Axial T-2 weighted images and fluid attenuated inversion recovery axial images were obtained using 3.0 T MR scanner. The severity of WMH was assessed separately for deep and periventricular WMH. Ordinal logistic regression models were used to assess the odds ratio for WMH. MA abusers had greater severity of WMH than the healthy comparison subjects (odds ratio: 7.06, 8.46, and 4.56 for all, deep, and periventricular WMH, respectively). Severity of deep WMH correlated with total cumulative dose of MA ( p = 0.027). Male MA abusers had greater severity of WMH than female MA abusers (odds ratio = 10.00). While male MA abusers had greater severity of WMH than male comparison subjects (odds ratio = 18.86), there was no significant difference in WMH severity between female MA abusers and female comparison subjects. The current study reports increased WMH in MA abusers, which may be related to MA-induced cerebral perfusion deficits. In addition, female MA abusers had less severe WMH than male MA abusers, possibly due to estrogen's protective effect against ischemic or neurotoxic effects of MA.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2005.05.016