Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics

Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metab...

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Veröffentlicht in:Neoplasia (New York, N.Y.) Jg. 11; H. 3; S. 269,IN7 - 276,IN10
Hauptverfasser: Tiziani, Stefano, Lopes, Victor, Günther, Ulrich L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 01.03.2009
Neoplasia Press Inc
Elsevier
Schlagworte:
Aged
Biomarkers, Tumor - blood
Early Detection of Cancer
Female
Humans
Magnetic Resonance Spectroscopy
Male
Metabolome
Metabolomics - methods
Middle Aged
Mouth Neoplasms - blood
Mouth Neoplasms - diagnosis
Neoplasm Staging
Neoplasms, Squamous Cell - blood
Neoplasms, Squamous Cell - diagnosis
ISSN:1476-5586, 1522-8002, 1476-5586, 1522-8002
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Abstract Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.
AbstractList Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.
Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.
Author Lopes, Victor
Günther, Ulrich L.
Tiziani, Stefano
AuthorAffiliation CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston, Birmingham, B15 2TT United Kingdom
Edinburgh Cancer Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU United Kingdom
AuthorAffiliation_xml – name: CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston, Birmingham, B15 2TT United Kingdom
– name: Edinburgh Cancer Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU United Kingdom
Author_xml – sequence: 1
  givenname: Stefano
  surname: Tiziani
  fullname: Tiziani, Stefano
  organization: CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston Birmingham B15 2TT United Kingdom
– sequence: 2
  givenname: Victor
  surname: Lopes
  fullname: Lopes, Victor
  organization: Edinburgh Cancer Centre, Western General Hospital, Crewe Road South Edinburgh EH4 2XU United Kingdom
– sequence: 3
  givenname: Ulrich L.
  surname: Günther
  fullname: Günther, Ulrich L.
  email: u.l.gunther@bham.ac.uk
  organization: CR UK Institute for Cancer Studies, University of Birmingham, Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB-NMR), Vincent Drive Edgbaston Birmingham B15 2TT United Kingdom
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19242608$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1039/b302360p
10.1007/s10334-006-0054-y
10.1016/j.joms.2006.09.015
10.1186/1471-2105-8-234
10.1002/hed.10125
10.1002/ijc.20651
10.1016/j.mehy.2006.04.048
10.1016/j.semcancer.2005.04.003
10.1093/annonc/mdl498
10.1159/000087910
10.1093/jnci/96.24.1805
10.1002/1097-0142(19920501)69:9<2343::AID-CNCR2820690924>3.0.CO;2-S
10.1002/nbm.1940040203
10.1097/01.pas.0000149687.90710.21
10.1016/j.pnmrs.2005.09.001
10.1002/ijc.20740
10.1006/jmra.1995.1047
10.1016/j.ab.2008.01.037
10.1002/jmri.20902
10.1002/(SICI)1099-1492(1998110)11:7<360::AID-NBM518>3.0.CO;2-P
10.1164/rccm.200606-769OC
10.1073/pnas.53.6.1410
10.1016/j.aca.2008.01.030
10.1093/annonc/mdi098
10.1002/nbm.1073
10.1146/annurev.nu.10.070190.000543
10.1002/cncr.11159
10.1063/1.431994
10.1002/nbm.1057
10.1158/0008-5472.CAN-06-2346
10.1016/j.jmr.2005.01.012
10.1006/jmre.2000.2071
10.1016/0960-7404(92)90086-Z
10.1039/b209155k
10.1021/pr0503782
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References Maheshwari, Mukherji, Neelon, Schiro, Fatterpekar, Stone, Castillo (bib18) 2000; 21
Boyle, Ferlay (bib1) 2005; 16
Star-Lack, Adalsteinsson, Adam, Terris, Pinto, Brown, Spielman (bib20) 2000; 21
Pisters, Cersosimo, Rogatko, Brennan (bib39) 1992; 111
Kunkel, Reichert, Benz, Lehr, Jeong, Wieand, Bartenstein, Wagner, Whiteside (bib22) 2003; 97
Arias-Mendoza, Payne, Zakian, Schwarz, Stubbs, Stoyanova, Ballon, Howe, Koutcher, Leach (bib15) 2006; 19
Odunsi, Wollman, Ambrosone, Hutson, McCann, Tammela, Geisler, Miller, Sellers, Cliby (bib10) 2005; 113
Mukherji, Schiro, Castillo, Kwock, Muller, Blackstock (bib19) 1997; 18
Beckwith-Hall, Thompson, Nicholson, Lindon, Holmes (bib5) 2003; 128
Parsons, Ludwig, Gunther, Viant (bib32) 2007; 8
Newman, Heslin, Wolf, Pisters, Brennan (bib37) 1992; 1
Brandwein-Gensler, Teixeira, Lewis, Lee, Rolnitzky, Hille, Genden, Urken, Wang (bib3) 2005; 29
Brindle, Nicholson, Schofield, Grainger, Holmes (bib6) 2003; 128
Hurd, John, Plant (bib30) 1991; 93
Ujpal, Barabas, Kovalszky, Szabo, Nemeth, Gabris, Suba (bib24) 2007; 65
Hwang, Shaka (bib28) 1995; 112
Duarte, Goodfellow, Barros, Jones, Barosa, Diogo, Garcia, Gill (bib8) 2007; 20
Whitehead, Kieber-Emmons (bib13) 2005; 47
Thrippleton, Edden, Keeler (bib29) 2005; 174
Pisters, Brennan (bib38) 1990; 10
Bezabeh, Odlum, Nason, Kerr, Sutherland, Patel, Smith (bib16) 2005; 26
Ching, Grossi, Jham, Angers, Zurawinsky, Ching, Nealon (bib45) 1984; 95
Aue, Karhan, Ernst (bib27) 1976; 64
Stubbs, Robinson, Hui, Price, Rodrigues, Howe, Griffiths (bib11) 2002
Ferlay, Autier, Boniol, Heanue, Colombet, Boyle (bib2) 2007; 18
Carraro, Rezzi, Reniero, Heberger, Giordano, Zanconato, Guillou, Baraldi (bib7) 2007; 175
Tsang, Huang, Holmes, Bahn (bib12) 2006; 5
El-Sayed, Bezabeh, Odlum, Patel, Ahing, MacDonald, Somorjai, Smith (bib17) 2002; 24
Kubota, Meguid, Hitch (bib44) 1992; 69
Lowry, Foster, Norton, Berman, Brennan (bib42) 1981; 66
Greene, Page, Fleming (bib25) 2002
Tiziani, Emwas, Lodi, Ludwig, Bunce, Viant, Gunther (bib26) 2008; 377
Lai, Lee, Lee, Wang, Chen (bib36) 2005; 15
Lardy, Paetkau, Walter (bib41) 1965; 53
Gunther, Ludwig, Ruterjans (bib31) 2000; 145
Bhawal, Ozaki, Nishimura, Sugiyama, Sasahira, Nomura, Sato, Fujimoto, Sasaki, Ikeda (bib23) 2005; 69
Miller (bib46) 1991; 4
Makinen, Soininen, Forsblom, Parkkonen, Ingman, Kaski, Groop, Ala-Korpela (bib9) 2006; 19
Adalsteinsson, Spielman, Pauly, Terris, Sommer, Macovski (bib14) 1998; 11
Bongaerts, van Hatteren, Verhagen, Wagener (bib40) 2006; 67
Carvalho, Nishimoto, Califano, Kowalski (bib4) 2005; 114
Garber (bib43) 2004; 96
Tiziani, Lodi, Ludwig, Parsons, Viant (bib33) 2008; 610
Viant (bib34) 2003; 310
Yokota, Guo, Matoba, Higashi, Tonami, Nagao (bib21) 2007; 25
Morvan, Demidem (bib35) 2007; 67
Carraro (10.1593/neo.81396_bib7) 2007; 175
Viant (10.1593/neo.81396_bib34) 2003; 310
Star-Lack (10.1593/neo.81396_bib20) 2000; 21
Brandwein-Gensler (10.1593/neo.81396_bib3) 2005; 29
Bhawal (10.1593/neo.81396_bib23) 2005; 69
Thrippleton (10.1593/neo.81396_bib29) 2005; 174
Tiziani (10.1593/neo.81396_bib33) 2008; 610
Lowry (10.1593/neo.81396_bib42) 1981; 66
Adalsteinsson (10.1593/neo.81396_bib14) 1998; 11
Odunsi (10.1593/neo.81396_bib10) 2005; 113
Lardy (10.1593/neo.81396_bib41) 1965; 53
Brindle (10.1593/neo.81396_bib6) 2003; 128
Morvan (10.1593/neo.81396_bib35) 2007; 67
Tsang (10.1593/neo.81396_bib12) 2006; 5
Newman (10.1593/neo.81396_bib37) 1992; 1
Arias-Mendoza (10.1593/neo.81396_bib15) 2006; 19
Tiziani (10.1593/neo.81396_bib26) 2008; 377
Boyle (10.1593/neo.81396_bib1) 2005; 16
Mukherji (10.1593/neo.81396_bib19) 1997; 18
Kunkel (10.1593/neo.81396_bib22) 2003; 97
Garber (10.1593/neo.81396_bib43) 2004; 96
Makinen (10.1593/neo.81396_bib9) 2006; 19
Greene (10.1593/neo.81396_bib25) 2002
Hwang (10.1593/neo.81396_bib28) 1995; 112
Miller (10.1593/neo.81396_bib46) 1991; 4
Beckwith-Hall (10.1593/neo.81396_bib5) 2003; 128
Whitehead (10.1593/neo.81396_bib13) 2005; 47
Duarte (10.1593/neo.81396_bib8) 2007; 20
Stubbs (10.1593/neo.81396_bib11) 2002
Ujpal (10.1593/neo.81396_bib24) 2007; 65
Parsons (10.1593/neo.81396_bib32) 2007; 8
Bongaerts (10.1593/neo.81396_bib40) 2006; 67
Kubota (10.1593/neo.81396_bib44) 1992; 69
Gunther (10.1593/neo.81396_bib31) 2000; 145
Pisters (10.1593/neo.81396_bib38) 1990; 10
Maheshwari (10.1593/neo.81396_bib18) 2000; 21
Carvalho (10.1593/neo.81396_bib4) 2005; 114
El-Sayed (10.1593/neo.81396_bib17) 2002; 24
Yokota (10.1593/neo.81396_bib21) 2007; 25
Lai (10.1593/neo.81396_bib36) 2005; 15
Ferlay (10.1593/neo.81396_bib2) 2007; 18
Bezabeh (10.1593/neo.81396_bib16) 2005; 26
Aue (10.1593/neo.81396_bib27) 1976; 64
Pisters (10.1593/neo.81396_bib39) 1992; 111
Hurd (10.1593/neo.81396_bib30) 1991; 93
Ching (10.1593/neo.81396_bib45) 1984; 95
References_xml – volume: 21
  start-page: 1930
  year: 2000
  end-page: 1935
  ident: bib18
  article-title: The choline/creatine ratio in five benign neoplasms: comparison with squamous cell carcinoma by use of in vitro MR spectroscopy
  publication-title: Am J Neuroradiol
– volume: 95
  start-page: 730
  year: 1984
  end-page: 738
  ident: bib45
  article-title: Plasma amino-acid and serum unesterified fatty-acid deficits and the effect of nutritional support in chemotherapy treatment
  publication-title: Surgery
– volume: 64
  start-page: 4226
  year: 1976
  end-page: 4227
  ident: bib27
  article-title: Homonuclear broad-band decoupling and 2-dimensional J-resolved NMR spectroscopy.
  publication-title: J Chem Phys
– volume: 1
  start-page: 257
  year: 1992
  end-page: 267
  ident: bib37
  article-title: The effect of insulin on glucose and protein metabolism in the forearm of cancer patients
  publication-title: Surg Oncol
– volume: 69
  start-page: 246
  year: 2005
  end-page: 255
  ident: bib23
  article-title: Association of expression of receptor for advanced glycation end products and invasive activity of oral squamous cell carcinoma
  publication-title: Oncology
– volume: 377
  start-page: 16
  year: 2008
  end-page: 23
  ident: bib26
  article-title: Optimized metabolite extraction from blood serum for H-1 nuclear magnetic resonance spectroscopy
  publication-title: Anal Biochem
– volume: 67
  start-page: 1213
  year: 2006
  end-page: 1222
  ident: bib40
  article-title: Cancer cachexia demonstrates the energetic impact of gluconeogenesis in human metabolism
  publication-title: Med Hypotheses
– volume: 53
  start-page: 1410
  year: 1965
  end-page: 1415
  ident: bib41
  article-title: Paths of carbon in gluconeogenesis and lipogenesis—role of mitochondria in supplying precursors of phosphoenol-pyruvate
  publication-title: Proc Natl Acad Sci USA
– volume: 19
  start-page: 281
  year: 2006
  end-page: 296
  ident: bib9
  article-title: Diagnosing diabetic nephropathy by H-1 NMR metabonomics of serum
  publication-title: Magn Reson Mat Phys Biol Med
– volume: 145
  start-page: 201
  year: 2000
  end-page: 208
  ident: bib31
  article-title: NMRLAB—advanced NMR data processing in MATLAB
  publication-title: J Magn Reson
– start-page: 131
  year: 2002
  end-page: 141
  ident: bib11
  publication-title: The importance of tumor metabolism in cancer prognosis and therapy; pre-clinical studies on rodent tumors with agents that improve tumor oxygenation
– volume: 310
  start-page: 943
  year: 2003
  end-page: 948
  ident: bib34
  article-title: Improved methods for the acquisition and interpretation of NMR metabolomic data
  publication-title: BMC Bioinformatics
– volume: 21
  start-page: 183
  year: 2000
  end-page: 193
  ident: bib20
  article-title: In vivo H-1 MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements
  publication-title: Am J Neuroradiol
– volume: 113
  start-page: 782
  year: 2005
  end-page: 788
  ident: bib10
  article-title: Detection of epithelial ovarian cancer using H-1-NMR–based metabonomics
  publication-title: Int J Cancer
– volume: 5
  start-page: 756
  year: 2006
  end-page: 760
  ident: bib12
  article-title: Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients
  publication-title: J Proteome Res
– volume: 93
  start-page: 666
  year: 1991
  end-page: 670
  ident: bib30
  article-title: Novel method for detection of pure-phase, double-absorption lineshapes in gradient-enhanced spectroscopy
  publication-title: J Magn Reson
– volume: 10
  start-page: 107
  year: 1990
  end-page: 132
  ident: bib38
  article-title: Amino-acid-metabolism in human cancer cachexia
  publication-title: Annu Rev Nutr
– volume: 66
  start-page: 653
  year: 1981
  end-page: 658
  ident: bib42
  article-title: Glucose disposal and gluconeogenesis from alanine in tumor-bearing Fischer-344 rats
  publication-title: J Natl Cancer Inst
– volume: 69
  start-page: 2343
  year: 1992
  end-page: 2348
  ident: bib44
  article-title: Amino-acid profiles correlate diagnostically with organ site in 3 kinds of malignant-tumors
  publication-title: Cancer
– volume: 11
  start-page: 360
  year: 1998
  end-page: 369
  ident: bib14
  article-title: Feasibility study of lactate imaging of head and neck tumors
  publication-title: NMR Biomed
– volume: 65
  start-page: 452
  year: 2007
  end-page: 456
  ident: bib24
  article-title: A preliminary comparative study of the prognostic implications of type 2 diabetes mellitus for patients with primary gingival carcinoma treated with surgery and radiation therapy
  publication-title: J Oral Maxillofac Surg
– year: 2002
  ident: bib25
  publication-title: AJCC Cancer Staging Manual
– volume: 25
  start-page: 992
  year: 2007
  end-page: 999
  ident: bib21
  article-title: Lactate, choline, and creatine levels measured by vitro H-1-MRS as prognostic parameters in patients with non–small-cell lung cancer
  publication-title: J Magn Reson Imaging
– volume: 29
  start-page: 167
  year: 2005
  end-page: 178
  ident: bib3
  article-title: Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival
  publication-title: Am J Surg Pathol
– volume: 19
  start-page: 504
  year: 2006
  end-page: 512
  ident: bib15
  article-title: In vivo P-31 MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial
  publication-title: NMR Biomed
– volume: 96
  start-page: 1805
  year: 2004
  end-page: 1806
  ident: bib43
  article-title: Energy boost: the Warburg effect returns in a new theory of cancer
  publication-title: J Natl Cancer Inst
– volume: 18
  start-page: 581
  year: 2007
  end-page: 592
  ident: bib2
  article-title: Estimates of the cancer incidence and mortality in Europe in 2006
  publication-title: Ann Oncol
– volume: 47
  start-page: 165
  year: 2005
  end-page: 174
  ident: bib13
  article-title: Applying in vitro NMR spectroscopy and H-1 NMR metabonomics to breast cancer characterization and detection
  publication-title: Prog Nucl Magn Reson Spectrosc
– volume: 26
  start-page: 2108
  year: 2005
  end-page: 2113
  ident: bib16
  article-title: Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy
  publication-title: Am J Neuroradiol
– volume: 8
  start-page: 234
  year: 2007
  ident: bib32
  article-title: Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation
  publication-title: BMC Bioinformatics
– volume: 15
  start-page: 267
  year: 2005
  end-page: 276
  ident: bib36
  article-title: Plasma free amino acid profile in cancer patients
  publication-title: Semin Cancer Biol
– volume: 24
  start-page: 766
  year: 2002
  end-page: 772
  ident: bib17
  article-title: An ex vivo study exploring the diagnostic potential of H-1 magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region
  publication-title: Head Neck J Sci Spec
– volume: 97
  start-page: 1015
  year: 2003
  end-page: 1024
  ident: bib22
  article-title: Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma
  publication-title: Cancer
– volume: 16
  start-page: 481
  year: 2005
  end-page: 488
  ident: bib1
  article-title: Cancer incidence and mortality in Europe, 2004
  publication-title: Ann Oncol
– volume: 128
  start-page: 814
  year: 2003
  end-page: 818
  ident: bib5
  article-title: A metabonomic investigation of hepatotoxicity using diffusion-edited H-1 NMR spectroscopy of blood serum
  publication-title: Analyst
– volume: 18
  start-page: 1057
  year: 1997
  end-page: 1072
  ident: bib19
  article-title: Proton MR spectroscopy of squamous cell carcinoma of the extracranial head and neck: in vitro and in vivo studies
  publication-title: Am J Neuroradiol
– volume: 175
  start-page: 986
  year: 2007
  end-page: 990
  ident: bib7
  article-title: Metabolomics applied to exhaled breath condensate in childhood asthma
  publication-title: Am J Respir Crit Care Med
– volume: 67
  start-page: 2150
  year: 2007
  end-page: 2159
  ident: bib35
  article-title: Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways
  publication-title: Cancer Res
– volume: 112
  start-page: 275
  year: 1995
  end-page: 279
  ident: bib28
  article-title: Water suppression that works—excitation sculpting using arbitrary wave-forms and pulsed-field gradients
  publication-title: J Magn Reson A
– volume: 174
  start-page: 97
  year: 2005
  end-page: 109
  ident: bib29
  article-title: Suppression of strong coupling artefacts in J-spectra
  publication-title: J Magn Reson
– volume: 128
  start-page: 32
  year: 2003
  end-page: 36
  ident: bib6
  article-title: Application of chemometrics to H-1 NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension
  publication-title: Analyst
– volume: 20
  start-page: 401
  year: 2007
  end-page: 412
  ident: bib8
  article-title: Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution H-1 NMR spectroscopy
  publication-title: NMR Biomed
– volume: 610
  start-page: 80
  year: 2008
  end-page: 88
  ident: bib33
  article-title: Effects of the application of different window functions and projection methods on processing of H-1 J-resolved nuclear magnetic resonance spectra for metabolomics
  publication-title: Anal Chim Acta
– volume: 111
  start-page: 301
  year: 1992
  end-page: 310
  ident: bib39
  article-title: Insulin action on glucose and branched-chain amino-acid-metabolism in cancer cachexia— differential-effects of insulin
  publication-title: Surgery
– volume: 114
  start-page: 806
  year: 2005
  end-page: 816
  ident: bib4
  article-title: Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database
  publication-title: Int J Cancer
– volume: 4
  start-page: 47
  year: 1991
  end-page: 52
  ident: bib46
  article-title: A review of chemical issues in 1H NMR spectroscopy: N -acetyl-L-aspartate, creatine and choline
  publication-title: NMR Biomed
– volume: 128
  start-page: 814
  year: 2003
  ident: 10.1593/neo.81396_bib5
  article-title: A metabonomic investigation of hepatotoxicity using diffusion-edited H-1 NMR spectroscopy of blood serum
  publication-title: Analyst
  doi: 10.1039/b302360p
– volume: 19
  start-page: 281
  year: 2006
  ident: 10.1593/neo.81396_bib9
  article-title: Diagnosing diabetic nephropathy by H-1 NMR metabonomics of serum
  publication-title: Magn Reson Mat Phys Biol Med
  doi: 10.1007/s10334-006-0054-y
– volume: 21
  start-page: 183
  year: 2000
  ident: 10.1593/neo.81396_bib20
  article-title: In vivo H-1 MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements
  publication-title: Am J Neuroradiol
– volume: 65
  start-page: 452
  year: 2007
  ident: 10.1593/neo.81396_bib24
  article-title: A preliminary comparative study of the prognostic implications of type 2 diabetes mellitus for patients with primary gingival carcinoma treated with surgery and radiation therapy
  publication-title: J Oral Maxillofac Surg
  doi: 10.1016/j.joms.2006.09.015
– volume: 8
  start-page: 234
  year: 2007
  ident: 10.1593/neo.81396_bib32
  article-title: Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-8-234
– volume: 24
  start-page: 766
  year: 2002
  ident: 10.1593/neo.81396_bib17
  article-title: An ex vivo study exploring the diagnostic potential of H-1 magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region
  publication-title: Head Neck J Sci Spec
  doi: 10.1002/hed.10125
– volume: 113
  start-page: 782
  year: 2005
  ident: 10.1593/neo.81396_bib10
  article-title: Detection of epithelial ovarian cancer using H-1-NMR–based metabonomics
  publication-title: Int J Cancer
  doi: 10.1002/ijc.20651
– volume: 67
  start-page: 1213
  year: 2006
  ident: 10.1593/neo.81396_bib40
  article-title: Cancer cachexia demonstrates the energetic impact of gluconeogenesis in human metabolism
  publication-title: Med Hypotheses
  doi: 10.1016/j.mehy.2006.04.048
– volume: 15
  start-page: 267
  year: 2005
  ident: 10.1593/neo.81396_bib36
  article-title: Plasma free amino acid profile in cancer patients
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2005.04.003
– volume: 18
  start-page: 581
  year: 2007
  ident: 10.1593/neo.81396_bib2
  article-title: Estimates of the cancer incidence and mortality in Europe in 2006
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdl498
– volume: 69
  start-page: 246
  year: 2005
  ident: 10.1593/neo.81396_bib23
  article-title: Association of expression of receptor for advanced glycation end products and invasive activity of oral squamous cell carcinoma
  publication-title: Oncology
  doi: 10.1159/000087910
– volume: 96
  start-page: 1805
  year: 2004
  ident: 10.1593/neo.81396_bib43
  article-title: Energy boost: the Warburg effect returns in a new theory of cancer
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/96.24.1805
– volume: 69
  start-page: 2343
  year: 1992
  ident: 10.1593/neo.81396_bib44
  article-title: Amino-acid profiles correlate diagnostically with organ site in 3 kinds of malignant-tumors
  publication-title: Cancer
  doi: 10.1002/1097-0142(19920501)69:9<2343::AID-CNCR2820690924>3.0.CO;2-S
– start-page: 131
  year: 2002
  ident: 10.1593/neo.81396_bib11
– volume: 4
  start-page: 47
  year: 1991
  ident: 10.1593/neo.81396_bib46
  article-title: A review of chemical issues in 1H NMR spectroscopy: N -acetyl-L-aspartate, creatine and choline
  publication-title: NMR Biomed
  doi: 10.1002/nbm.1940040203
– volume: 29
  start-page: 167
  year: 2005
  ident: 10.1593/neo.81396_bib3
  article-title: Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival
  publication-title: Am J Surg Pathol
  doi: 10.1097/01.pas.0000149687.90710.21
– volume: 47
  start-page: 165
  year: 2005
  ident: 10.1593/neo.81396_bib13
  article-title: Applying in vitro NMR spectroscopy and H-1 NMR metabonomics to breast cancer characterization and detection
  publication-title: Prog Nucl Magn Reson Spectrosc
  doi: 10.1016/j.pnmrs.2005.09.001
– volume: 95
  start-page: 730
  year: 1984
  ident: 10.1593/neo.81396_bib45
  article-title: Plasma amino-acid and serum unesterified fatty-acid deficits and the effect of nutritional support in chemotherapy treatment
  publication-title: Surgery
– volume: 21
  start-page: 1930
  year: 2000
  ident: 10.1593/neo.81396_bib18
  article-title: The choline/creatine ratio in five benign neoplasms: comparison with squamous cell carcinoma by use of in vitro MR spectroscopy
  publication-title: Am J Neuroradiol
– volume: 114
  start-page: 806
  year: 2005
  ident: 10.1593/neo.81396_bib4
  article-title: Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database
  publication-title: Int J Cancer
  doi: 10.1002/ijc.20740
– volume: 112
  start-page: 275
  year: 1995
  ident: 10.1593/neo.81396_bib28
  article-title: Water suppression that works—excitation sculpting using arbitrary wave-forms and pulsed-field gradients
  publication-title: J Magn Reson A
  doi: 10.1006/jmra.1995.1047
– volume: 111
  start-page: 301
  year: 1992
  ident: 10.1593/neo.81396_bib39
  article-title: Insulin action on glucose and branched-chain amino-acid-metabolism in cancer cachexia— differential-effects of insulin
  publication-title: Surgery
– volume: 377
  start-page: 16
  year: 2008
  ident: 10.1593/neo.81396_bib26
  article-title: Optimized metabolite extraction from blood serum for H-1 nuclear magnetic resonance spectroscopy
  publication-title: Anal Biochem
  doi: 10.1016/j.ab.2008.01.037
– volume: 18
  start-page: 1057
  year: 1997
  ident: 10.1593/neo.81396_bib19
  article-title: Proton MR spectroscopy of squamous cell carcinoma of the extracranial head and neck: in vitro and in vivo studies
  publication-title: Am J Neuroradiol
– volume: 25
  start-page: 992
  year: 2007
  ident: 10.1593/neo.81396_bib21
  article-title: Lactate, choline, and creatine levels measured by vitro H-1-MRS as prognostic parameters in patients with non–small-cell lung cancer
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.20902
– volume: 11
  start-page: 360
  year: 1998
  ident: 10.1593/neo.81396_bib14
  article-title: Feasibility study of lactate imaging of head and neck tumors
  publication-title: NMR Biomed
  doi: 10.1002/(SICI)1099-1492(1998110)11:7<360::AID-NBM518>3.0.CO;2-P
– volume: 175
  start-page: 986
  year: 2007
  ident: 10.1593/neo.81396_bib7
  article-title: Metabolomics applied to exhaled breath condensate in childhood asthma
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200606-769OC
– volume: 53
  start-page: 1410
  year: 1965
  ident: 10.1593/neo.81396_bib41
  article-title: Paths of carbon in gluconeogenesis and lipogenesis—role of mitochondria in supplying precursors of phosphoenol-pyruvate
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.53.6.1410
– volume: 310
  start-page: 943
  year: 2003
  ident: 10.1593/neo.81396_bib34
  article-title: Improved methods for the acquisition and interpretation of NMR metabolomic data
  publication-title: BMC Bioinformatics
– volume: 66
  start-page: 653
  year: 1981
  ident: 10.1593/neo.81396_bib42
  article-title: Glucose disposal and gluconeogenesis from alanine in tumor-bearing Fischer-344 rats
  publication-title: J Natl Cancer Inst
– volume: 610
  start-page: 80
  year: 2008
  ident: 10.1593/neo.81396_bib33
  article-title: Effects of the application of different window functions and projection methods on processing of H-1 J-resolved nuclear magnetic resonance spectra for metabolomics
  publication-title: Anal Chim Acta
  doi: 10.1016/j.aca.2008.01.030
– volume: 16
  start-page: 481
  year: 2005
  ident: 10.1593/neo.81396_bib1
  article-title: Cancer incidence and mortality in Europe, 2004
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdi098
– year: 2002
  ident: 10.1593/neo.81396_bib25
– volume: 20
  start-page: 401
  year: 2007
  ident: 10.1593/neo.81396_bib8
  article-title: Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution H-1 NMR spectroscopy
  publication-title: NMR Biomed
  doi: 10.1002/nbm.1073
– volume: 93
  start-page: 666
  year: 1991
  ident: 10.1593/neo.81396_bib30
  article-title: Novel method for detection of pure-phase, double-absorption lineshapes in gradient-enhanced spectroscopy
  publication-title: J Magn Reson
– volume: 10
  start-page: 107
  year: 1990
  ident: 10.1593/neo.81396_bib38
  article-title: Amino-acid-metabolism in human cancer cachexia
  publication-title: Annu Rev Nutr
  doi: 10.1146/annurev.nu.10.070190.000543
– volume: 97
  start-page: 1015
  year: 2003
  ident: 10.1593/neo.81396_bib22
  article-title: Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma
  publication-title: Cancer
  doi: 10.1002/cncr.11159
– volume: 64
  start-page: 4226
  year: 1976
  ident: 10.1593/neo.81396_bib27
  article-title: Homonuclear broad-band decoupling and 2-dimensional J-resolved NMR spectroscopy.
  publication-title: J Chem Phys
  doi: 10.1063/1.431994
– volume: 19
  start-page: 504
  year: 2006
  ident: 10.1593/neo.81396_bib15
  article-title: In vivo P-31 MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial
  publication-title: NMR Biomed
  doi: 10.1002/nbm.1057
– volume: 67
  start-page: 2150
  year: 2007
  ident: 10.1593/neo.81396_bib35
  article-title: Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-06-2346
– volume: 26
  start-page: 2108
  year: 2005
  ident: 10.1593/neo.81396_bib16
  article-title: Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy
  publication-title: Am J Neuroradiol
– volume: 174
  start-page: 97
  year: 2005
  ident: 10.1593/neo.81396_bib29
  article-title: Suppression of strong coupling artefacts in J-spectra
  publication-title: J Magn Reson
  doi: 10.1016/j.jmr.2005.01.012
– volume: 145
  start-page: 201
  year: 2000
  ident: 10.1593/neo.81396_bib31
  article-title: NMRLAB—advanced NMR data processing in MATLAB
  publication-title: J Magn Reson
  doi: 10.1006/jmre.2000.2071
– volume: 1
  start-page: 257
  year: 1992
  ident: 10.1593/neo.81396_bib37
  article-title: The effect of insulin on glucose and protein metabolism in the forearm of cancer patients
  publication-title: Surg Oncol
  doi: 10.1016/0960-7404(92)90086-Z
– volume: 128
  start-page: 32
  year: 2003
  ident: 10.1593/neo.81396_bib6
  article-title: Application of chemometrics to H-1 NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension
  publication-title: Analyst
  doi: 10.1039/b209155k
– volume: 5
  start-page: 756
  year: 2006
  ident: 10.1593/neo.81396_bib12
  article-title: Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients
  publication-title: J Proteome Res
  doi: 10.1021/pr0503782
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Snippet Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is...
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SubjectTerms Aged
Biomarkers, Tumor - blood
Early Detection of Cancer
Female
Humans
Magnetic Resonance Spectroscopy
Male
Metabolome
Metabolomics - methods
Middle Aged
Mouth Neoplasms - blood
Mouth Neoplasms - diagnosis
Neoplasm Staging
Neoplasms, Squamous Cell - blood
Neoplasms, Squamous Cell - diagnosis
Title Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics
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