Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining...

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Veröffentlicht in:	Cell metabolism Jg. 28; H. 1; S. 159
Hauptverfasser:	Sustarsic, Elahu G, Ma, Tao, Lynes, Matthew D, Larsen, Michael, Karavaeva, Iuliia, Havelund, Jesper F, Nielsen, Carsten H, Jedrychowski, Mark P, Moreno-Torres, Marta, Lundh, Morten, Plucinska, Kaja, Jespersen, Naja Z, Grevengoed, Trisha J, Kramar, Barbara, Peics, Julia, Hansen, Jakob B, Shamsi, Farnaz, Forss, Isabel, Neess, Ditte, Keipert, Susanne, Wang, Jianing, Stohlmann, Katharina, Brandslund, Ivan, Christensen, Cramer, Jørgensen, Marit E, Linneberg, Allan, Pedersen, Oluf, Kiebish, Michael A, Qvortrup, Klaus, Han, Xianlin, Pedersen, Bente Klarlund, Jastroch, Martin, Mandrup, Susanne, Kjær, Andreas, Gygi, Steven P, Hansen, Torben, Gillum, Matthew P, Grarup, Niels, Emanuelli, Brice, Nielsen, Søren, Scheele, Camilla, Tseng, Yu-Hua, Færgeman, Nils J, Gerhart-Hines, Zachary
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.07.2018
Schlagworte:	Adipocytes - metabolism Adipose Tissue, Beige - metabolism Adipose Tissue, Brown - metabolism Animals Cardiolipins - biosynthesis Cells, Cultured Energy Metabolism Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mitochondria - metabolism Thermogenesis Transferases (Other Substituted Phosphate Groups) - genetics Transferases (Other Substituted Phosphate Groups) - metabolism beige adipose thermogenesis brown adipose mitochondria lipid metabolism CHOP-10 phospholipids CRLS1 cardiolipin insulin resistance
ISSN:	1932-7420, 1932-7420
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