Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells

The dysfunction and cell death of retinal pigment epithelial (RPE) cells are hallmarks of late-stage dry (atrophic) age-related macular degeneration (AMD), for which no effective therapy has yet been developed. Previous studies have indicated that iron accumulation is a source of excess free radical...

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Bibliographic Details
Published in:	Experimental eye research Vol. 181; pp. 316 - 324
Main Authors:	Totsuka, Kiyohito, Ueta, Takashi, Uchida, Takatoshi, Roggia, Murilo F., Nakagawa, Suguru, Vavvas, Demetrios G., Honjo, Megumi, Aihara, Makoto
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2019
Subjects:	Apoptosis - physiology Cell Death Cell Survival Cells, Cultured Ferroptosis Ferroptosis - physiology Humans Iron - metabolism Lipid Peroxidation Macular Degeneration - metabolism Macular Degeneration - pathology Oxidative stress Oxidative Stress - physiology Reactive Oxygen Species - metabolism Retinal pigment epithelial cells Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Retinal pigment epithelial cells Oxidative stress Ferroptosis Cell death
ISSN:	0014-4835, 1096-0007, 1096-0007
Online Access:	Get full text
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