The potential role of leptin in tumor invasion and metastasis

Red: Tumor-promoting effect. Blue: Dual role (tumor–suppressor or −promoting effect depending on the situation). CAFs: Cancer-associated fibroblasts, CTGF: Connective tissue growth factor, EGFR: Epidermal growth factor receptor, EMT: Epithelial–mesenchymal transition, ERK1/2: Extracellular signal-re...

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Vydáno v:Cytokine & growth factor reviews Ročník 38; s. 80 - 97
Hlavní autoři: Ray, Amitabha, Cleary, Margot P.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.12.2017
Témata:
Invasive cancer
Leptin
Metastasis
Obesity
Prognosis
TAM
MCP-1
Prognosis
Metastasis
TNF
EGFR
CTGF
TNM
PI3K
Invasive cancer
Ob-R
Obesity
IL
HIF
ICAM
NSCLC
VEGF
CAF
IGF
AKT
EMT
ER
ECM
MMP
STAT
TGF
JAK
Leptin
ERK
ISSN:1359-6101, 1879-0305, 1879-0305
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Abstract Red: Tumor-promoting effect. Blue: Dual role (tumor–suppressor or −promoting effect depending on the situation). CAFs: Cancer-associated fibroblasts, CTGF: Connective tissue growth factor, EGFR: Epidermal growth factor receptor, EMT: Epithelial–mesenchymal transition, ERK1/2: Extracellular signal-regulated kinases 1 and 2, HER2: Human epidermal growth factor receptor 2, HIF-1α: Hypoxia-inducible factor-1 alpha, IGF-I: Insulin-like growth factor-I, JAK2: Janus kinase 2, MMPs: Matrix metalloproteinases, NF-κB: Nuclear factor-kappa B, Ob-R: Leptin receptor, PI3K: Phosphatidylinositol 3-kinase, STAT3: Signal transducer and activator of transcription 3, TAMs: Tumor-associated macrophages, TGF-β: Transforming growth factor-beta, VEGF: Vascular endothelial growth factor. [Display omitted] •In the tumor microenvironment leptin impacts intracellular signaling which may accelerate cancer cell migration and metastasis.•Leptin plays a role in cancers of the digestive and reproductive systems, which are a major burden of neoplastic disease worldwide.•Elevated serum leptin affects the prognosis of both adenocarcinomas and squamous cell carcinomas.•Several cancer dissemination mechanisms have been documented to be linked with leptin. The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin’s association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin's potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients.
AbstractList The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin's association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin's potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients.The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin's association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin's potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients.
The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin’s association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin’s potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients. Leptin-linked Pathological Mechanisms in Tumor Proliferation and Migration Red: Tumor-promoting effect Blue: Dual role (tumor–suppressor or –promoting effect depending on the situation) CAFs: Cancer-associated fibroblasts, CTGF: Connective tissue growth factor, EGFR: Epidermal growth factor receptor, EMT: Epithelial–mesenchymal transition, ERK1/2: Extracellular signal-regulated kinases 1 and 2, HER2: Human epidermal growth factor receptor 2, HIF-1α: Hypoxia-inducible factor-1 alpha, IGF-I: Insulin-like growth factor-I, JAK2: Janus kinase 2, MMPs: Matrix metalloproteinases, NF-κB: Nuclear factor-kappa B, Ob-R: Leptin receptor, PI3K: Phosphatidylinositol 3-kinase, STAT3: Signal transducer and activator of transcription 3, TAMs: Tumor-associated macrophages, TGF-β: Transforming growth factor-beta, VEGF: Vascular endothelial growth factor
Red: Tumor-promoting effect. Blue: Dual role (tumor–suppressor or −promoting effect depending on the situation). CAFs: Cancer-associated fibroblasts, CTGF: Connective tissue growth factor, EGFR: Epidermal growth factor receptor, EMT: Epithelial–mesenchymal transition, ERK1/2: Extracellular signal-regulated kinases 1 and 2, HER2: Human epidermal growth factor receptor 2, HIF-1α: Hypoxia-inducible factor-1 alpha, IGF-I: Insulin-like growth factor-I, JAK2: Janus kinase 2, MMPs: Matrix metalloproteinases, NF-κB: Nuclear factor-kappa B, Ob-R: Leptin receptor, PI3K: Phosphatidylinositol 3-kinase, STAT3: Signal transducer and activator of transcription 3, TAMs: Tumor-associated macrophages, TGF-β: Transforming growth factor-beta, VEGF: Vascular endothelial growth factor. [Display omitted] •In the tumor microenvironment leptin impacts intracellular signaling which may accelerate cancer cell migration and metastasis.•Leptin plays a role in cancers of the digestive and reproductive systems, which are a major burden of neoplastic disease worldwide.•Elevated serum leptin affects the prognosis of both adenocarcinomas and squamous cell carcinomas.•Several cancer dissemination mechanisms have been documented to be linked with leptin. The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin’s association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin's potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients.
The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese individuals, elevated leptin levels act as a pro-inflammatory adipokine and are associated with certain types of cancers. Further, a growing body of evidence suggests that higher circulating leptin concentrations and/or elevated expression of leptin receptors (Ob-R) in tumors may be poor prognostic factors. Although the underlying pathological mechanisms of leptin's association with poor prognosis are not clear, leptin can impact the tumor microenvironment in several ways. For example, leptin is associated with a number of biological components that could lead to tumor cell invasion and distant metastasis. This includes interactions with carcinoma-associated fibroblasts, tumor promoting effects of infiltrating macrophages, activation of matrix metalloproteinases, transforming growth factor-β signaling, etc. Recent studies also have shown that leptin plays a role in the epithelial-mesenchymal transition, an important phenomenon for cancer cell migration and/or metastasis. Furthermore, leptin's potentiating effects on insulin-like growth factor-I, epidermal growth factor receptor and HER2/neu have been reported. Regarding unfavorable prognosis, leptin has been shown to influence both adenocarcinomas and squamous cell carcinomas. Features of poor prognosis such as tumor invasion, lymph node involvement and distant metastasis have been recorded in several cancer types with higher levels of leptin and/or Ob-R. This review will describe the current scenario in a precise manner. In general, obesity indicates poor prognosis in cancer patients.
Author Cleary, Margot P.
Ray, Amitabha
AuthorAffiliation b The Hormel Institute, University of Minnesota, Austin, MN 55912
a Lake Erie College of Osteopathic Medicine, Seton Hill University, Greensburg, PA 15601
AuthorAffiliation_xml – name: a Lake Erie College of Osteopathic Medicine, Seton Hill University, Greensburg, PA 15601
– name: b The Hormel Institute, University of Minnesota, Austin, MN 55912
Author_xml – sequence: 1
  givenname: Amitabha
  surname: Ray
  fullname: Ray, Amitabha
  organization: Lake Erie College of Osteopathic Medicine, Seton Hill University, Greensburg, PA 15601, United States
– sequence: 2
  givenname: Margot P.
  surname: Cleary
  fullname: Cleary, Margot P.
  email: mpcleary@hi.umn.edu
  organization: The Hormel Institute, University of Minnesota, Austin, MN 55912, United States
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29158066$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1371/journal.pone.0166172
10.1016/j.canlet.2005.05.047
10.1016/j.biocel.2012.12.010
10.1007/s00432-011-1054-5
10.1007/s10585-010-9347-7
10.1371/journal.pone.0126686
10.1136/jclinpath-2013-201870
10.1080/01635581.2014.894104
10.1371/journal.pone.0041942
10.1038/s41540-017-0018-z
10.1530/ERC-11-0075
10.1002/cncr.24389
10.3727/096504014X13887748696662
10.1007/s00018-007-7388-0
10.4161/adip.23645
10.18632/oncotarget.11761
10.1016/j.ejogrb.2013.04.004
10.1158/1078-0432.CCR-03-0749
10.1016/j.clinbiochem.2011.11.016
10.1016/j.biopha.2012.03.002
10.1158/0008-5472.CAN-06-3075
10.1074/jbc.M110.168542
10.1016/j.lfs.2014.11.007
10.1007/s10549-015-3550-9
10.1186/bcr3605
10.1007/s00280-015-2710-2
10.1590/S0004-27302010000700002
10.1042/BJ20051578
10.1371/journal.pone.0178454
10.1016/j.juro.2006.06.039
10.1002/glia.22729
10.1016/j.ejogrb.2014.05.040
10.1097/IGC.0000000000000440
10.1681/ASN.2013040432
10.1007/s13402-017-0342-8
10.1002/pros.22972
10.1007/s10555-010-9252-1
10.1093/carcin/bgp023
10.1111/pcmr.12584
10.1158/1078-0432.CCR-06-2645
10.4161/cbt.27541
10.1007/s12020-012-9788-7
10.3390/cancers5031140
10.1016/j.jbo.2016.03.004
10.1093/molehr/gav039
10.7150/jca.5112
10.3892/ijo.2013.1789
10.1038/srep21782
10.1016/j.bbi.2016.10.008
10.1002/glia.20773
10.1152/ajprenal.00209.2013
10.1016/j.jtbi.2015.08.014
10.1111/jcmm.12517
10.1371/journal.pone.0184451
10.1677/JOE-08-0215
10.1016/j.lungcan.2011.01.002
10.1093/carcin/bgt028
10.1097/00029330-200709020-00009
10.3892/mmr.2013.1786
10.1371/journal.pone.0160125
10.1371/journal.pone.0123217
10.18632/oncotarget.15736
10.1038/ijo.2014.37
10.3892/or.2013.2390
10.3892/ol.2014.2059
10.4049/jimmunol.1600476
10.1158/0008-5472.CAN-08-1952
10.1159/000454696
10.1007/s12038-011-9172-4
10.1111/apm.12370
10.1007/s10549-015-3318-2
10.3748/wjg.v18.i28.3745
10.1002/cncr.22677
10.1097/PDM.0b013e318297afea
10.1038/bjc.2014.70
10.3233/CBM-140415
10.1007/s13277-013-0842-8
10.3892/or.2015.3783
10.18632/oncotarget.17853
10.4067/S0034-98872014000500007
10.7150/jca.16884
10.1158/0008-5472.CAN-07-6682
10.1097/MD.0000000000003073
10.1007/s12038-012-9191-9
10.1002/ddr.20265
10.1186/s13046-016-0446-4
10.1186/s13039-016-0297-x
10.1016/j.molonc.2014.11.006
10.3892/ijo.2016.3530
10.3892/ijo.2015.2845
10.1016/j.ygyno.2017.07.007
10.1016/S0083-6729(05)71012-8
10.1038/oncsis.2016.65
10.20892/j.issn.2095-3941.2016.0079
10.1007/s00795-015-0130-3
10.1007/s00428-016-1938-5
10.3727/096504009X12596189659367
10.1007/s12272-016-0820-y
10.4103/0973-1482.163840
10.1677/ERC-09-0153
10.1186/1756-9966-31-32
10.1016/j.ejso.2013.11.012
10.3892/or.2014.3128
10.1111/j.1440-1746.2007.04941.x
10.1038/nature08689
10.1186/s12929-017-0356-6
10.1002/cncr.25630
10.2147/CLEP.S47150
10.1016/j.surg.2009.11.004
10.7314/APJCP.2015.16.6.2495
10.3892/ol.2013.1125
10.1186/s12885-016-2411-1
10.1177/1010428317699130
10.1016/j.pharmthera.2013.01.008
10.1186/bcr1988
10.18632/oncotarget.14153
10.1210/er.2010-0030
10.1016/j.lfs.2015.05.003
10.1007/s10585-008-9231-x
10.3325/cmj.2017.58.96
10.1007/s11626-013-9629-x
10.1016/j.biocel.2016.12.002
10.1186/1471-2407-12-50
10.1080/15384047.2015.1056409
10.1038/bjc.2014.45
10.4252/wjsc.v7.i2.253
10.1158/1078-0432.CCR-04-0174
10.3748/wjg.v12.i34.5517
10.1111/obr.12321
10.1016/j.tcb.2013.06.001
10.1007/s13105-012-0231-6
10.1155/2015/253519
10.1080/15384101.2015.1041684
10.1016/j.biocel.2016.01.002
10.1007/978-3-319-48382-5_25
10.1371/journal.pone.0170675
10.1002/jcp.22455
10.1016/j.biopha.2014.03.010
10.1097/PPO.0000000000000281
10.18632/oncotarget.3347
10.2174/138920309789630561
10.1615/CritRevOncog.v18.i1-2.40
10.1158/0008-5472.CAN-10-3323
10.18632/oncotarget.13946
10.18632/oncotarget.8336
10.1039/C5MB00101C
10.1016/j.fct.2017.05.058
10.1111/jcmm.12413
10.1530/JOE-14-0264
10.1016/j.amjsurg.2004.07.031
10.1016/j.prp.2012.05.009
10.7150/ijms.8251
10.1016/j.peptides.2012.10.002
10.1016/j.neo.2015.11.005
10.5604/17322693.1130084
10.1111/bph.13100
10.1007/s12013-010-9145-5
10.1016/j.cellsig.2017.01.020
10.1002/ijc.28983
10.1530/JOE-13-0033
10.1007/s12272-016-0795-8
10.1186/s13058-014-0426-6
10.1186/s12916-017-0900-y
10.1523/JNEUROSCI.0353-12.2012
10.1371/journal.pone.0130839
10.3109/07357900902769749
10.1016/j.canlet.2014.08.001
10.4049/jimmunol.174.12.8090
10.1111/cen.12598
10.1007/s00432-015-2023-1
10.18632/oncotarget.13342
10.1016/j.bbalip.2013.02.010
10.18632/oncotarget.4228
10.1074/jbc.M111.322800
10.1097/MOG.0000000000000274
10.1016/j.clbc.2016.07.009
10.1111/j.1463-1318.2011.02562.x
10.1186/s13058-015-0622-z
10.1186/s12885-016-2422-y
10.1093/asj/sjv194
10.1515/hmbci-2013-0069
10.1007/s10549-015-3401-8
10.3748/wjg.v16.i39.4986
10.1016/j.humpath.2016.03.001
10.1016/j.anndiagpath.2012.09.004
10.3892/ijo.2017.3846
10.3892/ijo.2016.3483
10.1007/s13277-015-3375-5
10.1007/s10549-010-1012-y
10.1093/carcin/bgx071
10.1186/s13046-017-0494-4
10.1590/S0102-67202011000400005
10.1016/j.peptides.2008.05.011
10.18632/oncotarget.3878
10.1371/journal.pone.0021467
10.1186/1471-2407-12-35
10.1371/journal.pone.0119348
10.18632/oncotarget.4367
10.1089/thy.2013.0232
10.1002/1873-3468.12771
10.18632/oncotarget.3587
10.1186/1476-4598-11-79
10.1677/ERC-09-0225
10.4331/wjbc.v6.i2.39
10.3892/or.2014.3536
10.2353/ajpath.2010.100595
10.18632/oncotarget.13846
10.1038/cddis.2017.21
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Keywords TAM
MCP-1
Prognosis
Metastasis
TNF
EGFR
CTGF
TNM
PI3K
Invasive cancer
Ob-R
Obesity
IL
HIF
ICAM
NSCLC
VEGF
CAF
IGF
AKT
EMT
ER
ECM
MMP
STAT
TGF
JAK
Leptin
ERK
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References Pantuck, Seligson, Klatte, Yu, Leppert, Moore (bib0460) 2007; 109
Wang, Chen, Chen, Duan, Xu, Wei (bib0580) 2012; 37
Yeh, Lu, Lee, Fu (bib1105) 2009; 57
Nieman, Romero, Van Houten, Lengyel (bib0085) 2013; 1831
Han, Wang (bib0230) 2015; 8
Dozio, Ruscica, Galliera, Corsi, Magni (bib0220) 2009; 10
Wei, Mingliang, Yong, Suyang (bib0320) 2015; 11
Liu, Wang, Zheng, Tang (bib0870) 2013; 170
Meyer, Neeley, Baker, Washabaugh, Flesher, Nelson (bib0105) 2016; 7
Holck, Bonde, Pedersen, Petersen, Chaube, Nielsen (bib0440) 2016; 54
Frankenberry, Somasundar, McFadden, Vona-Davis (bib1040) 2004; 188
Choi, Byeon, Kim, Lee, Kwon, Ahn (bib0515) 2015; 10
Harada, Baba, Shigaki, Ishimoto, Miyake, Kosumi (bib0365) 2016; 16
Malvi, Chaube, Pandey, Vijayakumar, Boreddy, Mohammad (bib0800) 2015; 9
Ding, Cao, Wang, Wang, Zhang, Zhang (bib1030) 2016; 11
Park, Kusminski, Chua, Scherer (bib0705) 2010; 177
Marwarha, Ghribi (bib0195) 2012; 1
Deng, Cui, Jiang, Zhang, Zhang, Hao (bib0280) 2014; 6
Kim, Jin, Kim, Khanal, Lee, Kim (bib0865) 2017; 106
Torisu-Itakura, Lee, Scheri, Huynh, Ye, Essner (bib0810) 2007; 13
Gonzalez-Perez, Lanier, Newman (bib0930) 2013; 5
Zou, Liu, Wei, Wang, Wang, Huang (bib0565) 2016; 49
Harbuzariu, Rampoldi, Daley-Brown, Candelaria, Harmon, Lipsey (bib0860) 2017; 8
Shouman, Wagih, Kamel (bib0890) 2016; 13
Del Carmen Martínez-Jiménez, Méndez-Mancilla, Patricia Portales-Pérez (bib0995) 2017
Feng, Liu, Zhang, Zheng, Sang, Feng (bib0070) 2013; 21
Zhang, Yao, Song, Liao, Xian, Li (bib0725) 2015; 7
Dai, Bercury, Macklin (bib0395) 2014; 62
Cao, Huang, Wang, Wang, Pang, Li (bib0740) 2016; 7
Zhou, Li, Chai, Liu (bib0910) 2015; 25
Bochukova, Huang, Keogh, Henning, Purmann, Blaszczyk (bib0975) 2010; 463
Yang, Chen, Tsou, Huang, Yang, Su (bib0765) 2009; 30
Fava, Alpini, Rychlicki, Saccomanno, DeMorrow, Trozzi (bib1035) 2008; 68
Strong, Ohlstein, Biagas, Rhodes, Pei, Tucker (bib0055) 2015; 17
Tercioti-Junior, Lopes, Coelho-Neto (bib0500) 2011; 24
Hadler-Olsen, Winberg, Uhlin-Hansen (bib0020) 2013; 34
Liu, Xiao, Bai, Yu, Sun, Zhao (bib0315) 2014; 32
Jia, Chang, Sun, Zhu, Pang, Tao (bib0450) 2014; 7
Liu, Wan, Pan, Cao, Wu, Lu (bib0585) 2011; 60
Hunter, Crawford, Alsarraj (bib0945) 2008; 10
Chen, Chung, Yeh, Chaung, Kuo, Fu (bib0680) 2006; 237
Ji, Zhang, Chu, Gan, Ren, Zhang (bib0295) 2016; 11
McDaniel, Varley, Gertz, Savic, Roberts, Bailey (bib0325) 2017; 8
Schmid, Ricci, Behrens, Leitzmann (bib0615) 2015; 16
Koontongkaew (bib0015) 2013; 4
Shen, Wang, Zhao, Zhou (bib0925) 2009; 2
Zhao, Gao, Wang, Liu, Yuan, Zhang (bib0305) 2011; 73
Shi, Yao, Liu, Wang, Lv, Zhang (bib0370) 2012; 12
Dong, Fu, Xu, Yang, Du, Li (bib0545) 2014; 110
Liu, Zhou, Chen, Yi, Chen, Ba (bib0375) 2010; 16
Jiang, Sun, Sun (bib0235) 2014; 8
Templeton, Lie, Wang, Rosenberg-Hasson, Alluri, Tamaresis (bib0745) 2015; 17
Ding, Jin, Chen, Shao, Wu (bib1165) 2012; 7
David, Jett, LeBeau, Dy, Hughes, Friedman (bib0445) 2004; 10
Firoozinia, Zareian Jahromi, Moghadamtousi, Nikzad, Abdul Kadir (bib0350) 2014; 11
Hair, Xu, Kirk, Harlid, Sandhu, Robinson (bib0990) 2015; 151
Pachmayr, Treese, Stein (bib1025) 2017; 33
Bain, Collie-Duguid, Murray, Gilbert, Denison, McKiddie (bib0555) 2014; 110
Knight, Oprea-Ilies, Nagalingam, Yang, Cohen, Saxena (bib1060) 2011; 18
Gungorduk, Ertas, Sahbaz, Ozvural, Sarica, Ozdemir (bib0405) 2014; 179
Fan, Li (bib0625) 2015; 83
Yu, Zhao, Wang, Liu (bib0310) 2015; 75
Perera, Chin, Duru, Camarillo (bib0750) 2008; 199
Wicki, Christofori (bib0940) 2008
Saxena, Taliaferro-Smith, Knight, Merlin, Anania, O'Regan (bib0755) 2008; 68
Blanquer-Rosselló Mdel, Oliver, Sastre-Serra, Valle, Roca (bib0835) 2016; 72
Clement, Lazar, Muller, Nieto (bib0790) 2017; 30
Wang, Cao, Pang, Li, Dang, Tang (bib1095) 2013; 29
Dubois, Jardé, Delort, Billard, Bernard-Gallon, Berger (bib0850) 2014; 66
Duan, Tang, Zhang, Yu (bib0510) 2014; 36
Chen, Liu, Jiao, Peng, Huo, Yang (bib0270) 2015; 8
Xu, Shao, Zhao, Geng, Wang, Yin (bib0815) 2011; 137
Trevellin, Scarpa, Carraro, Lunardi, Kotsafti, Porzionato (bib0505) 2015; 6
Rhee (bib1135) 2016; 39
Cui, Maimaitiyiming, Qi, Norman, Wang (bib0045) 2013; 305
Divella, De Luca, Abbate, Naglieri, Daniele (bib0135) 2016; 7
Zhao, Huang, Zhu, Chen, Hu (bib0525) 2007; 22
Masoud, Li (bib0610) 2015; 5
Wei, Li, Pang, Guo, Su, Huang (bib1100) 2016; 35
Erkasap, Ozkurt, Erkasap, Yasar, Uzuner, Ihtiyar (bib0595) 2013; 46
Cheng, Chi, Tzen, Yang, Lee, Liu (bib0635) 2010; 147
Pawlina (bib1170) 2016
Xia, Gu, Bai, Yu (bib0695) 2009; 122
Yan, Yang, Huang (bib1005) 2013; 28
Martínez-Martínez, Miana, Jurado-López, Bartolomé, Souza Neto, Salaices (bib0040) 2014; 38
Ray, Cleary (bib0050) 2012; 45
Kato, Abarzua-Catalan, Trigo, Delpiano, Sanhueza, García (bib0080) 2015; 6
Ghasemi, Hashemy, Aghaei, Panjehpour (bib1045) 2017; 32
Acedo, Gambero, Cunha, Lorand-Metze, Gambero (bib1150) 2013; 49
Sobrinho Santos, Guimarães, Santos, Cangussu, de Jesus, Fraga (bib1090) 2017; 39
Ribatti, Belloni, Nico, Di Comite, Crivellato, Vacca (bib0935) 2008; 29
McSherry, Donatello, Hopkins, McDonnell (bib0010) 2007; 64
Madeddu, Gramignano, Floris, Murenu, Sollai, Macciò (bib0665) 2014; 18
Prokop, Duff, Ball, Copeland, Londraville (bib0200) 2012; 38
Li, Zhang, Zheng, Guo (bib0410) 2015; 8
Arsenic, Lehmann, Budczies, Koch, Prinzler, Kleine-Tebbe (bib0345) 2014; 22
Font-Clos, Zapperi, La Porta (bib0795) 2017; 3
Yan, DeMars (bib0820) 2010; 27
Xiang, Wu, Liu, Shi, Wang, Li (bib0095) 2016; 84
Kim, Yi, Ye (bib0245) 2016; 39
Yoon, Ko, Cho, Park, Choi, Choi (bib0255) 2015; 123
Cheung, Ding, Gunta, Gu, Tabakman, Klapper (bib1190) 2014; 25
Clawson, Matters, Xin, McGovern, Wafula, dePamphilis (bib1160) 2017; 12
Noda, Kikugawa, Tanji, Miura, Asai, Higashiyama (bib1080) 2015; 46
Catalano, Leggio, Barone, De Marco, Gelsomino, Campana (bib0560) 2015; 19
Lee, Jung, Koo (bib0155) 2015; 153
Ma, Lan, Zheng, Xie, Wang, Liu (bib0480) 2012; 11
Engin (bib0660) 2017; 960
Alshaker, Krell, Frampton, Waxman, Blyuss, Zaikin (bib0700) 2014; 16
Zhang, Chen, Heiman, Dimarchi (bib0205) 2005; 71
D'Esposito, Liguoro, Ambrosio, Collina, Cantile, Spinelli (bib0150) 2016; 7
Yang, Wang, Li, Cao, Sun, Jin (bib0960) 2017; 38
Siveen, Sikka, Surana, Dai, Zhang, Kumar (bib0240) 2014; 1845
Tsujino, Nakanishi, Hiranuma, Shimizu, Hirotani, Ohni (bib0475) 2016; 49
Zhang, Hou, Han, Zhou, Wang, Cui (bib0630) 2013; 5
Gui, Pan, Chen, Xu, Luo, Chen (bib0655) 2017; 8
Hajagos-Tóth, Ducza, Samavati, Vari, Gaspar (bib1015) 2017; 58
Ray (bib0005) 2012; 37
Wen, Xing, Harris, Zaytseva, Mitov, Napier (bib0100) 2017; 8
Ribeiro, Monteiro, Cunha, Oliveira, Freitas, Fraga (bib0120) 2012; 31
Yuan, Zhang, Li, Mao, Mo, Du (bib1125) 2017; 147
Dong, Xu, Du, Yang, Cheng, Zhang (bib0540) 2013; 34
Xu, Lu (bib0300) 2014; 40
Zhu, Yu, Li, Ke, Guo, Xiao (bib0385) 2012; 18
Baba, Nosho, Shima, Hayashi, Meyerhardt, Chan (bib0455) 2011; 117
Li, Huang (bib0250) 2017; 50
Chen, Lu, Gan, Chen, He, Fan (bib0435) 2015; 16
Ren, Jia, Zhao, Zhang, Chen, Yang (bib0605) 2014; 354
Ptak, Kolaczkowska, Gregoraszczuk (bib0880) 2013; 43
Wang, Gao, Meng, Qiao, Wang (bib0170) 2015; 10
Huang, Yu, Lai, Yeh, Su, Hsu (bib0760) 2011; 226
Chin, Wang, Hsieh, Shih, Nana, Changou (bib0845) 2017; 24
Uriarte, Paternain, Milagro, Martínez, Campion (bib0980) 2013; 69
Wolfson, Eades, Zhou (bib0185) 2015; 6
Zhang, Liu, Li, Ai (bib0650) 2014; 14
Seyfried, Huysentruyt (bib1155) 2013; 18
Xu, Dong, Li, Yang, Yuan, Qu (bib0895) 2013; 45
Frühbeck (bib0225) 2006; 393
Chen, Chang, Lan, Breslin (bib0840) 2013; 42
Yang, Li, Hou, Yan, Xu, Chen (bib0265) 2017; 8
Blouet, Liu, Jo, Chua, Schwartz (bib1020) 2012; 32
Fan, Gan, Shen, Cai, Song, Zhao (bib0600) 2015; 6
Werner, Kelly, Issa (bib0965) 2017; 23
Ishikawa, Kitayama, Nagawa (bib0535) 2006; 12
Nepal, Kim, Hong, Kim, Sohn, Lee (bib0875) 2015; 6
Yun, Jia, Li, Yuan, Sun, Yu (bib0430) 2013; 6
Oba, Wei, Gershenwald, Johnson, Wyatt, Ellerhorst (bib0785) 2016; 95
Zhu, Harvey, Macura, Euhus, Artemov (bib0125) 2017; 17
Saxena, Sharma, Ding, Lin, Marra, Merlin (bib1085) 2007; 67
Zhao, Qu, Sun, Wang, Liu, Wang (bib1120) 2017; 8
Peelman, Zabeau, Moharana, Savvides, Tavernier (bib0215) 2014; 223
Bruno, Conus, Schmid, Simon (bib1010) 2005; 174
Zhong, Liu, Liu, Xiong, Liu (bib0290) 2014; 17
Grossmann, Mizuno, Bonorden, Ray, Sokolchik, Narasimhan (bib0775) 2009; 18
Horiguchi, Sumitomo, Asakuma, Asano, Zheng, Asano (bib0780) 2006; 176
Yu, Li, Wang, Wang, Chen, Cai (bib0275) 2016; 142
Ghasemi, Isaac Hashemy, Aghaei, Panjehpour (bib1050) 2017
Fletcher, Sacca, Pistone-Creydt, Coló, Serra, Santino (bib0130) 2017; 36
Cheng, Yin, Hsu, Chang, Huang, Lee (bib0645) 2011; 26
Yuan, Zhang, Cai, Ding, Wang, Chen (bib0920) 2013; 29
Mendelová, Jezková, Zubor, Holubeková, Lasabová, Plank (bib0355) 2014; 79
Wang, Deng, Cai, Fu, Li, Zhou (bib0415) 2015; 6
Berg, Schreier, Miksztowicz (bib0035) 2014; 17
Yan, Avtanski, Saxena, Sharma (bib0065) 2012; 287
Ersahin, Tuncbag, Cetin-Atalay (bib0400) 2015; 11
Gu, Jin, Wang, Hua, Yang, Shu (bib0380) 2014; 68
Braune, Weyer, Hobusch, Mauer, Brüning, Bechmann (bib1140) 2017; 198
Yuan, Sun, Yu (bib1110) 2014; 9
Song, Sun, Liu, Liu, Chen, Zhang (bib0285) 2014; 8
Ito, Ishiguro, Kobayashi, Hasumi, Watanabe, Yao (bib0115) 2015; 75
Pappa, Alevizaki (bib0620) 2014; 24
Guo, Gonzalez-Perez (bib0710) 2011; 6
Tserga, Chatziandreou, Michalopoulos, Patsouris, Saetta (bib0360) 2016; 469
Wang, Tang, Cao, Li, Pang, Zhong (bib0075) 2015; 16
Caswell, Swanton (bib0955) 2017; 15
Mendonsa, Chalfant, Gorden, VanSaun (bib1070) 2015; 10
Uddin, Bavi, Siraj, Ahmed, Al-Rasheed, Hussain (bib0640) 2010; 17
Tai, Lee, Chen, Wang, Jiang, Su (bib0490) 2013; 17
Bloomfield, Duesberg (bib0950) 2016; 9
Campbell, Nuttall, Griffiths, Gumbleton (bib0470) 2009; 115
Assiri, Kamel, Hassanien (bib0670) 2015; 2015
Liu, Samad, Mueller (bib0190) 2013; 2
McMurtry, Simeone, Nieves-Alicea, Tari (bib0715) 2009; 26
Chimal-Vega, Paniagua-Castro, Carrillo Vazquez, Rosas-Trigueros, Zamorano-Carrillo, Benítez-Cardoza (bib0210) 2015; 385
Liu, Wang, Chen (bib0770) 2008; 69
Aleskandarany, Rakha, Ahmed, Powe, Ellis, Green (bib0425) 2011; 127
Makrilia, Kollias, Manolopoulos, Syrigos (bib0550) 2009; 27
Valladares, Corsini, Romero (bib0915) 2014; 142
Tasioudi, Saetta, Sakellariou, Levidou, Michalopoulos, T
Engin (10.1016/j.cytogfr.2017.11.002_bib0660) 2017; 960
Li (10.1016/j.cytogfr.2017.11.002_bib0410) 2015; 8
Ghasemi (10.1016/j.cytogfr.2017.11.002_bib1050) 2017
Liu (10.1016/j.cytogfr.2017.11.002_bib0190) 2013; 2
Braune (10.1016/j.cytogfr.2017.11.002_bib1140) 2017; 198
Zhu (10.1016/j.cytogfr.2017.11.002_bib0125) 2017; 17
Ribatti (10.1016/j.cytogfr.2017.11.002_bib0935) 2008; 29
Clawson (10.1016/j.cytogfr.2017.11.002_bib1160) 2017; 12
Clement (10.1016/j.cytogfr.2017.11.002_bib0790) 2017; 30
Wen (10.1016/j.cytogfr.2017.11.002_bib0100) 2017; 8
Ratke (10.1016/j.cytogfr.2017.11.002_bib0590) 2010; 17
Ghasemi (10.1016/j.cytogfr.2017.11.002_bib1045) 2017; 32
Fletcher (10.1016/j.cytogfr.2017.11.002_bib0130) 2017; 36
Wei (10.1016/j.cytogfr.2017.11.002_bib0320) 2015; 11
Ding (10.1016/j.cytogfr.2017.11.002_bib1030) 2016; 11
Kim (10.1016/j.cytogfr.2017.11.002_bib0865) 2017; 106
Yan (10.1016/j.cytogfr.2017.11.002_bib0065) 2012; 287
Rhee (10.1016/j.cytogfr.2017.11.002_bib1135) 2016; 39
Yunusova (10.1016/j.cytogfr.2017.11.002_bib0570) 2015; 61
Ren (10.1016/j.cytogfr.2017.11.002_bib0605) 2014; 354
Werner (10.1016/j.cytogfr.2017.11.002_bib0965) 2017; 23
McSherry (10.1016/j.cytogfr.2017.11.002_bib0010) 2007; 64
Fujisaki (10.1016/j.cytogfr.2017.11.002_bib0165) 2015; 150
Hair (10.1016/j.cytogfr.2017.11.002_bib0990) 2015; 151
Fan (10.1016/j.cytogfr.2017.11.002_bib0600) 2015; 6
Martín (10.1016/j.cytogfr.2017.11.002_bib1065) 2017; 12
Ding (10.1016/j.cytogfr.2017.11.002_bib1165) 2012; 7
Bain (10.1016/j.cytogfr.2017.11.002_bib0555) 2014; 110
Madeddu (10.1016/j.cytogfr.2017.11.002_bib0665) 2014; 18
Dubois (10.1016/j.cytogfr.2017.11.002_bib0850) 2014; 66
Wang (10.1016/j.cytogfr.2017.11.002_bib1095) 2013; 29
Masoud (10.1016/j.cytogfr.2017.11.002_bib0610) 2015; 5
Dong (10.1016/j.cytogfr.2017.11.002_bib0545) 2014; 110
Donato (10.1016/j.cytogfr.2017.11.002_bib0330) 2010; 54
Hajagos-Tóth (10.1016/j.cytogfr.2017.11.002_bib1015) 2017; 58
Yang (10.1016/j.cytogfr.2017.11.002_bib0765) 2009; 30
Firoozinia (10.1016/j.cytogfr.2017.11.002_bib0350) 2014; 11
Geng (10.1016/j.cytogfr.2017.11.002_bib0530) 2012; 66
Ray (10.1016/j.cytogfr.2017.11.002_bib0005) 2012; 37
Lin (10.1016/j.cytogfr.2017.11.002_bib0420) 2006; 36
Jia (10.1016/j.cytogfr.2017.11.002_bib0450) 2014; 7
Healy (10.1016/j.cytogfr.2017.11.002_bib0575) 2012; 14
Park (10.1016/j.cytogfr.2017.11.002_bib0705) 2010; 177
Zhou (10.1016/j.cytogfr.2017.11.002_bib0910) 2015; 25
Harbuzariu (10.1016/j.cytogfr.2017.11.002_bib0860) 2017; 8
Martínez-Martínez (10.1016/j.cytogfr.2017.11.002_bib0040) 2014; 38
Wang (10.1016/j.cytogfr.2017.11.002_bib0580) 2012; 37
Saxena (10.1016/j.cytogfr.2017.11.002_bib1085) 2007; 67
Noda (10.1016/j.cytogfr.2017.11.002_bib1080) 2015; 46
Mishra (10.1016/j.cytogfr.2017.11.002_bib1075) 2017; 12
Arsenic (10.1016/j.cytogfr.2017.11.002_bib0345) 2014; 22
Wei (10.1016/j.cytogfr.2017.11.002_bib1100) 2016; 35
Hunter (10.1016/j.cytogfr.2017.11.002_bib0945) 2008; 10
Makrilia (10.1016/j.cytogfr.2017.11.002_bib0550) 2009; 27
Horiguchi (10.1016/j.cytogfr.2017.11.002_bib0780) 2006; 176
Yuan (10.1016/j.cytogfr.2017.11.002_bib1110) 2014; 9
Huang (10.1016/j.cytogfr.2017.11.002_bib0760) 2011; 226
Saxena (10.1016/j.cytogfr.2017.11.002_bib0755) 2008; 68
Xiong (10.1016/j.cytogfr.2017.11.002_bib0090) 2015; 7
Zhao (10.1016/j.cytogfr.2017.11.002_bib0305) 2011; 73
Yan (10.1016/j.cytogfr.2017.11.002_bib1005) 2013; 28
Yao-Borengasser (10.1016/j.cytogfr.2017.11.002_bib0160) 2015; 33
Tai (10.1016/j.cytogfr.2017.11.002_bib0490) 2013; 17
Peelman (10.1016/j.cytogfr.2017.11.002_bib0215) 2014; 223
Yang (10.1016/j.cytogfr.2017.11.002_bib0960) 2017; 38
Moreira (10.1016/j.cytogfr.2017.11.002_bib0110) 2015; 10
Hadler-Olsen (10.1016/j.cytogfr.2017.11.002_bib0020) 2013; 34
Pantuck (10.1016/j.cytogfr.2017.11.002_bib0460) 2007; 109
Dai (10.1016/j.cytogfr.2017.11.002_bib0395) 2014; 62
Assiri (10.1016/j.cytogfr.2017.11.002_bib0670) 2015; 2015
Zhang (10.1016/j.cytogfr.2017.11.002_bib0725) 2015; 7
Cao (10.1016/j.cytogfr.2017.11.002_bib0740) 2016; 7
Gungorduk (10.1016/j.cytogfr.2017.11.002_bib0405) 2014; 179
Wang (10.1016/j.cytogfr.2017.11.002_bib0170) 2015; 10
Prokop (10.1016/j.cytogfr.2017.11.002_bib0200) 2012; 38
Oba (10.1016/j.cytogfr.2017.11.002_bib0785) 2016; 95
Ersahin (10.1016/j.cytogfr.2017.11.002_bib0400) 2015; 11
McMurtry (10.1016/j.cytogfr.2017.11.002_bib0715) 2009; 26
Wicki (10.1016/j.cytogfr.2017.11.002_bib0940) 2008
Dozio (10.1016/j.cytogfr.2017.11.002_bib0220) 2009; 10
Massa (10.1016/j.cytogfr.2017.11.002_bib0145) 2016; 36
Tsujino (10.1016/j.cytogfr.2017.11.002_bib0475) 2016; 49
Yu (10.1016/j.cytogfr.2017.11.002_bib0275) 2016; 142
McDaniel (10.1016/j.cytogfr.2017.11.002_bib0325) 2017; 8
Aleskandarany (10.1016/j.cytogfr.2017.11.002_bib0425) 2011; 127
Feng (10.1016/j.cytogfr.2017.11.002_bib0070) 2013; 21
Fazolini (10.1016/j.cytogfr.2017.11.002_bib0830) 2015; 14
Ishikawa (10.1016/j.cytogfr.2017.11.002_bib0535) 2006; 12
Uriarte (10.1016/j.cytogfr.2017.11.002_bib0980) 2013; 69
Torisu-Itakura (10.1016/j.cytogfr.2017.11.002_bib0810) 2007; 13
Chapnik (10.1016/j.cytogfr.2017.11.002_bib1175) 2013; 217
Bochukova (10.1016/j.cytogfr.2017.11.002_bib0975) 2010; 463
Liu (10.1016/j.cytogfr.2017.11.002_bib0870) 2013; 170
Dirat (10.1016/j.cytogfr.2017.11.002_bib0180) 2011; 71
Catalano (10.1016/j.cytogfr.2017.11.002_bib0560) 2015; 19
Campbell (10.1016/j.cytogfr.2017.11.002_bib0470) 2009; 115
Thrift (10.1016/j.cytogfr.2017.11.002_bib0495) 2016; 32
Shi (10.1016/j.cytogfr.2017.11.002_bib0370) 2012; 12
Chin (10.1016/j.cytogfr.2017.11.002_bib0845) 2017; 24
Xu (10.1016/j.cytogfr.2017.11.002_bib0895) 2013; 45
Guo (10.1016/j.cytogfr.2017.11.002_bib0710) 2011; 6
Cheng (10.1016/j.cytogfr.2017.11.002_bib0645) 2011; 26
Sobrinho Santos (10.1016/j.cytogfr.2017.11.002_bib1090) 2017; 39
Baba (10.1016/j.cytogfr.2017.11.002_bib0455) 2011; 117
Alshaker (10.1016/j.cytogfr.2017.11.002_bib0700) 2014; 16
Frankenberry (10.1016/j.cytogfr.2017.11.002_bib1040) 2004; 188
Ishikawa (10.1016/j.cytogfr.2017.11.002_bib0690) 2004; 10
Jiang (10.1016/j.cytogfr.2017.11.002_bib0235) 2014; 8
Barrichon (10.1016/j.cytogfr.2017.11.002_bib0825) 2015; 172
Zhang (10.1016/j.cytogfr.2017.11.002_bib0260) 2015; 33
Yan (10.1016/j.cytogfr.2017.11.002_bib0820) 2010; 27
Uddin (10.1016/j.cytogfr.2017.11.002_bib0640) 2010; 17
Zhang (10.1016/j.cytogfr.2017.11.002_bib0205) 2005; 71
Dong (10.1016/j.cytogfr.2017.11.002_bib0540) 2013; 34
Font-Clos (10.1016/j.cytogfr.2017.11.002_bib0795) 2017; 3
Ito (10.1016/j.cytogfr.2017.11.002_bib0115) 2015; 75
Zhao (10.1016/j.cytogfr.2017.11.002_bib0525) 2007; 22
Ray (10.1016/j.cytogfr.2017.11.002_bib0050) 2012; 45
Cui (10.1016/j.cytogfr.2017.11.002_bib0045) 2013; 305
Duan (10.1016/j.cytogfr.2017.11.002_bib0510) 2014; 36
Qi (10.1016/j.cytogfr.2017.11.002_bib0805) 2014; 43
Zou (10.1016/j.cytogfr.2017.11.002_bib0565) 2016; 49
Song (10.1016/j.cytogfr.2017.11.002_bib0285) 2014; 8
Meyer (10.1016/j.cytogfr.2017.11.002_bib0105) 2016; 7
Cheung (10.1016/j.cytogfr.2017.11.002_bib1190) 2014; 25
Lee (10.1016/j.cytogfr.2017.11.002_bib0155) 2015; 153
Choi (10.1016/j.cytogfr.2017.11.002_bib0515) 2015; 10
Li (10.1016/j.cytogfr.2017.11.002_bib0720) 2016; 48
Malvi (10.1016/j.cytogfr.2017.11.002_bib0800) 2015; 9
Liu (10.1016/j.cytogfr.2017.11.002_bib0375) 2010; 16
Erkasap (10.1016/j.cytogfr.2017.11.002_bib0595) 2013; 46
Deng (10.1016/j.cytogfr.2017.11.002_bib0280) 2014; 6
Berg (10.1016/j.cytogfr.2017.11.002_bib0035) 2014; 17
Sheen (10.1016/j.cytogfr.2017.11.002_bib0335) 2016; 5
Frühbeck (10.1016/j.cytogfr.2017.11.002_bib0225) 2006; 393
Xu (10.1016/j.cytogfr.2017.11.002_bib0815) 2011; 137
Ell (10.1016/j.cytogfr.2017.11.002_bib0970) 2013; 23
Del Carmen Martínez-Jiménez (10.1016/j.cytogfr.2017.11.002_bib0995) 2017
Blanquer-Rosselló Mdel (10.1016/j.cytogfr.2017.11.002_bib0835) 2016; 72
Divella (10.1016/j.cytogfr.2017.11.002_bib0135) 2016; 7
Pokrywka (10.1016/j.cytogfr.2017.11.002_bib0985) 2014; 68
Koontongkaew (10.1016/j.cytogfr.2017.11.002_bib0015) 2013; 4
Sousa (10.1016/j.cytogfr.2017.11.002_bib1130) 2016; 5
Shouman (10.1016/j.cytogfr.2017.11.002_bib0890) 2016; 13
Ji (10.1016/j.cytogfr.2017.11.002_bib0295) 2016; 11
Acedo (10.1016/j.cytogfr.2017.11.002_bib1150) 2013; 49
Park (10.1016/j.cytogfr.2017.11.002_bib0175) 2011; 32
Caswell (10.1016/j.cytogfr.2017.11.002_bib0955) 2017; 15
Fava (10.1016/j.cytogfr.2017.11.002_bib1035) 2008; 68
Habib (10.1016/j.cytogfr.2017.11.002_bib0855) 2015; 121
Zhong (10.1016/j.cytogfr.2017.11.002_bib0290) 2014; 17
Liu (10.1016/j.cytogfr.2017.11.002_bib0585) 2011; 60
Ahn (10.1016/j.cytogfr.2017.11.002_bib0030) 2015; 21
Kato (10.1016/j.cytogfr.2017.11.002_bib0080) 2015; 6
Qian (10.1016/j.cytogfr.2017.11.002_bib0885) 2015; 36
David (10.1016/j.cytogfr.2017.11.002_bib0445) 2004; 10
Kim (10.1016/j.cytogfr.2017.11.002_bib0245) 2016; 39
Zhu (10.1016/j.cytogfr.2017.11.002_bib0385) 2012; 18
Fan (10.1016/j.cytogfr.2017.11.002_bib0625) 2015; 83
Giordano (10.1016/j.cytogfr.2017.11.002_bib0025) 2016; 6
Yang (10.1016/j.cytogfr.2017.11.002_bib0265) 2017; 8
Zhang (10.1016/j.cytogfr.2017.11.002_bib0630) 2013; 5
Xia (10.1016/j.cytogfr.2017.11.002_bib0695) 2009; 122
Yoon (10.1016/j.cytogfr.2017.11.002_bib0900) 2014; 31
Yu (10.1016/j.cytogfr.2017.11.002_bib0905) 2016; 7
Trevellin (10.1016/j.cytogfr.2017.11.002_bib0505) 2015; 6
Grossmann (10.1016/j.cytogfr.2017.11.002_bib0775) 2009; 18
Seyfried (10.1016/j.cytogfr.2017.11.002_bib1155) 2013; 18
Nepal (10.1016/j.cytogfr.2017.11.002_bib0875) 2015; 6
Yun (10.1016/j.cytogfr.2017.11.002_bib0430) 2013; 6
Nieman (10.1016/j.cytogfr.2017.11.002_bib0085) 2013; 1831
Dent (10.1016/j.cytogfr.2017.11.002_bib0390) 2014; 15
Rabold (10.1016/j.cytogfr.2017.11.002_bib1115) 2017; 591
Marwarha (10.1016/j.cytogfr.2017.11.002_bib0195) 2012; 1
Gui (10.1016/j.cytogfr.2017.11.002_bib0655) 2017; 8
Tasioudi (10.1016/j.cytogfr.2017.11.002_bib0485) 2012; 208
Bruno (10.1016/j.cytogfr.2017.11.002_bib1010) 2005; 174
Gu (10.1016/j.cytogfr.2017.11.002_bib0380) 2014; 68
Ptak (10.1016/j.cytogfr.2017.11.002_bib0880) 2013; 43
Liu (10.1016/j.cytogfr.2017.11.002_bib0315) 2014; 32
Schmid (10.1016/j.cytogfr.2017.11.002_bib0615) 2015; 16
Chen (10.1016/j.cytogfr.2017.11.002_bib0435) 2015; 16
Chen (10.1016/j.cytogfr.2017.11.002_bib0680) 2006; 237
27797363 - Oncogenesis. 2016 Oct 31;5(10 ):e267
15944317 - J Immunol. 2005 Jun 15;174(12):8090-6
25653024 - Oncol Rep. 2015 Apr;33(4):1872-82
27820851 - PLoS One. 2016 Nov 7;11(11):e0166172
25192370 - Breast Cancer Res. 2014 Jan 23;16(1):201
16336196 - Biochem J. 2006 Jan 1;393(Pt 1):7-20
25337238 - Int J Clin Exp Pathol. 2014 Aug 15;7(9):5940-9
27059323 - Virchows Arch. 2016 Jul;469(1):35-43
23879222 - Thyroid. 2014 Feb;24(2):190-9
26696367 - Neoplasia. 2015 Dec;17 (12 ):849-861
24548863 - Br J Cancer. 2014 Apr 2;110(7):1801-10
22658382 - Pathol Res Pract. 2012 Jul 15;208(7):398-404
25846563 - APMIS. 2015 May;123(5):373-82
23708919 - In Vitro Cell Dev Biol Anim. 2013 Jun;49(6):473-8
23262295 - Int J Biochem Cell Biol. 2013 Mar;45(3):536-45
24782652 - Int J Med Sci. 2014 Apr 22;11(6):620-5
27515050 - Arch Pharm Res. 2016 Aug;39(8):1085-99
23334856 - J Physiol Biochem. 2013 Sep;69(3):601-11
25158596 - Clin Endocrinol (Oxf). 2015 Aug;83(2):261-7
26365757 - Obes Rev. 2015 Dec;16(12):1042-54
28685099 - NPJ Syst Biol Appl. 2017 Jun 30;3:18
19168585 - Carcinogenesis. 2009 Apr;30(4):566-74
28030809 - Oncotarget. 2017 Jan 31;8(5):8226-8238
25919692 - PLoS One. 2015 Apr 28;10(4):e0126686
25823469 - Oncol Rep. 2015 Jun;33(6):2689-94
25909054 - Iran J Public Health. 2014 Jul;43(7):857-66
25815113 - World J Stem Cells. 2015 Mar 26;7(2):253-65
21927908 - J Cancer Res Clin Oncol. 2011 Dec;137(12):1841-8
25857300 - Oncotarget. 2015 May 10;6(13):11203-15
23383396 - Am J Neurodegener Dis. 2012;1(3):245-65
26009703 - World J Biol Chem. 2015 May 26;6(2):39-47
24213635 - Mol Med Rep. 2014 Jan;9(1):350-4
21056997 - Am J Pathol. 2010 Dec;177(6):3133-44
27617308 - Biochem Biophys Rep. 2016 Sep;7:144-149
26499941 - Aesthet Surg J. 2016 Mar;36(3):358-63
28594107 - Mol Nutr Food Res. 2017 Jun 8;:null
27743935 - Brain Behav Immun. 2017 Feb;60:151-160
28770546 - Cell Oncol (Dordr). 2017 Dec;40(6):537-547
17957337 - Cell Mol Life Sci. 2007 Dec;64(24):3201-18
26986135 - Medicine (Baltimore). 2016 Mar;95(11):e3073
23681802 - Tumour Biol. 2013 Aug;34(4):2041-51
22851869 - World J Gastroenterol. 2012 Jul 28;18(28):3745-51
25846733 - Tumour Biol. 2015 Sep;36(9):6813-21
24115476 - J Am Soc Nephrol. 2014 Jan;25(1):119-28
28193830 - J Immunol. 2017 Apr 1;198(7):2927-2934
19091006 - Breast Cancer Res. 2008;10 Suppl 1:S2
22815502 - J Neurosci. 2012 Jul 18;32(29):9870-7
27387344 - BMC Cancer. 2016 Jul 07;16:419
23500888 - Biochim Biophys Acta. 2013 Oct;1831(10):1533-41
16112274 - Vitam Horm. 2005;71:345-72
28427165 - Oncotarget. 2017 May 2;8(18):30576-30586
20008098 - Endocr Relat Cancer. 2010 Feb 18;17(1):191-202
22270359 - J Biol Chem. 2012 Mar 9;287(11):8598-612
17908478 - Chin Med J (Engl). 2007 Sep 20;120(18):1592-6
23425972 - Oncol Lett. 2013 Mar;5(3):797-800
22357207 - J Biosci. 2012 Mar;37(1):91-101
27568102 - Clin Breast Cancer. 2017 Feb;17 (1):e11-e18
29088874 - Oncotarget. 2017 May 13;8(43):75389-75399
25953686 - Breast Cancer Res Treat. 2015 Jun;151(2):453-63
22968658 - Endocrine. 2013 Apr;43(2):394-403
28911002 - Carcinogenesis. 2017 Sep 1;38(9):900-909
15501963 - Clin Cancer Res. 2004 Oct 15;10(20):6865-71
25785029 - Int J Clin Exp Med. 2015 Jan 15;8(1):546-57
24953370 - Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jun;17(6):594-7
16951269 - Ann Clin Lab Sci. 2006 Summer;36(3):283-93
24844408 - Int J Cancer. 2015 Jan 15;136(2):258-70
25060812 - Glia. 2014 Dec;62(12):2096-109
25628786 - Am J Transl Res. 2014 Nov 22;6(6):756-67
25130171 - Cancer Lett. 2014 Nov 1;354(1):172-80
27504822 - PLoS One. 2016 Aug 09;11(8):e0160125
21333372 - Lung Cancer. 2011 Sep;73(3):366-74
26286584 - Breast Cancer Res. 2015 Aug 19;17:112
23588620 - Oncol Rep. 2013 Jun;29(6):2291-6
24424114 - Cancer Biol Ther. 2014 Mar 1;15(3):245-6
20697780 - Clin Exp Metastasis. 2010 Dec;27(8):581-90
23991363 - Adipocyte. 2013 Jul 1;2(3):165-9
18701500 - Cancer Res. 2008 Aug 15;68(16):6752-61
26579469 - Acta Pharm Sin B. 2015 Sep;5(5):378-89
28785563 - Visc Med. 2017 Mar;33(1):11-20
23482705 - J Endocrinol. 2013 Apr 29;217(3):283-90
25998029 - Life Sci. 2015 Nov 1;140:57-63
26705127 - Med Mol Morphol. 2016 Jun;49(2):98-109
25721149 - J Cell Mol Med. 2015 May;19(5):1122-32
21161731 - Cell Biochem Biophys. 2011 Jul;60(3):241-4
19526593 - Cancer. 2009 Aug 1;115(15):3457-67
25838618 - Dis Markers. 2015;2015:253519
19909018 - Cancer Invest. 2009 Dec;27(10):1023-37
21731759 - PLoS One. 2011;6(6):e21467
23353703 - Pharmacol Ther. 2013 May;138(2):197-210
23932299 - Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):198-201
25811593 - Int J Gynecol Cancer. 2015 Jun;25(5):770-8
28716075 - BMC Med. 2017 Jul 18;15(1):133
26121010 - Cancer Biol Ther. 2015;16(8):1220-30
24471188 - Appl Immunohistochem Mol Morphol. 2014 Jan;22(1):50-6
21689278 - Colorectal Dis. 2012 Feb;14 (2):157-65
27863383 - Oncotarget. 2016 Dec 27;7(52):86075-86086
27761375 - J Bone Oncol. 2016 Apr 08;5(3):135-138
21425139 - Cancer. 2011 Apr 1;117(7):1399-408
25499031 - Mol Oncol. 2015 Mar;9(3):689-703
18573568 - Peptides. 2008 Sep;29(9):1596-602
15240518 - Clin Cancer Res. 2004 Jul 1;10(13):4325-31
26342543 - J Theor Biol. 2015 Nov 21;385:90-101
28222242 - Pigment Cell Melanoma Res. 2017 May;30(3):294-306
27994674 - J Cancer. 2016 Nov 26;7(15):2346-2359
22469146 - J Exp Clin Cancer Res. 2012 Apr 02;31:32
21750869 - Oncol Rep. 2011 Nov;26(5):1265-71
23354006 - Int J Oncol. 2013 Mar;42(3):1113-9
28885729 - J Cell Biochem. 2017 Sep 8;:null
20954287 - World J Gastroenterol. 2010 Oct 21;16(39):4986-91
21642230 - Endocr Rev. 2011 Aug;32(4):550-70
24583853 - Int J Obes (Lond). 2014 Dec;38(12):1565-72
21555376 - Endocr Relat Cancer. 2011 Jul 01;18(4):413-28
26323925 - J Cancer Res Ther. 2015 Aug;11 Suppl 1:C56-8
25433128 - Life Sci. 2015 Jan 15;121:10-5
23558862 - Braz J Med Biol Res. 2013 Mar;46(3):306-10
25338520 - J Cell Mol Med. 2014 Dec;18(12):2519-29
19952122 - Endocr Relat Cancer. 2010 Feb 18;17(1):179-89
26153131 - Mol Hum Reprod. 2015 Oct;21(10):792-802
28585217 - Adv Exp Med Biol. 2017;960:571-606
24265323 - J Clin Pathol. 2014 Apr;67(4):333-40
24227920 - Clin Epidemiol. 2013 Nov 01;5(Suppl 1):3-29
17545514 - Clin Cancer Res. 2007 Jun 1;13(11):3125-32
28249041 - PLoS One. 2017 Mar 1;12 (3):e0170675
28151470 - Cell Death Dis. 2017 Feb 2;8(2):e2593
22178111 - Clin Biochem. 2012 Feb;45(3):189-97
22292935 - BMC Cancer. 2012 Feb 01;12:50
20821253 - Cancer Metastasis Rev. 2010 Dec;29(4):641-53
20843817 - J Biol Chem. 2010 Nov 19;285(47):36551-60
20045163 - Surgery. 2010 Jun;147(6):847-53
23085324 - Peptides. 2012 Dec;38(2):326-36
21459803 - Cancer Res. 2011 Apr 1;71(7):2455-65
18715880 - J Endocrinol. 2008 Nov;199(2):221-33
19751193 - Curr Protein Pept Sci. 2009 Dec;10(6):577-84
23183114 - Ann Diagn Pathol. 2013 Apr;17(2):165-71
25625287 - Int J Oncol. 2015 Apr;46(4):1535-42
24700392 - Oncol Rep. 2014 Jun;31(6):2493-8
23348381 - Histol Histopathol. 2013 Mar;28(3):285-92
22883999 - Biomed Pharmacother. 2012 Sep;66(6):419-24
24133589 - Int J Clin Exp Pathol. 2013 Sep 15;6(10 ):2112-20
26053184 - Oncotarget. 2015 Aug 28;6(25):21100-19
25704884 - Oncotarget. 2015 Mar 30;6(9):7166-81
24388873 - Biochim Biophys Acta. 2014 Apr;1845(2):136-54
26124180 - Oncotarget. 2015 Jul 30;6(21):18674-82
27082857 - Int J Oncol. 2016 Jun;48(6):2479-87
25484575 - Drug Des Devel Ther. 2014 Nov 14;8:2295-302
17006991 - World J Gastroenterol. 2006 Sep 14;12(34):5517-22
25531701 - Postepy Hig Med Dosw (Online). 2014 Nov 27;68:1383-91
25917126 - Prostate. 2015 Jul 1;75(10):1009-19
20617378 - Breast Cancer Res Treat. 2011 Jun;127(2):407-16
24965996 - Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:147-52
25721605 - Breast Cancer Res Treat. 2015 Apr;150(2):255-63
20225764 - Oncol Res. 2009;18(5-6):269-77
28571770 - Food Chem Toxicol. 2017 Aug;106(Pt A):232-241
25924008 - Mol Biosyst. 2015 Jul;11(7):1946-54
28542577 - PLoS One. 2017 May 25;12 (5):e0178454
27562774 - Arch Pharm Res. 2016 Nov;39(11):1588-1596
20945385 - J Cell Physiol. 2011 May;226(5):1274-82
26692918 - Am J Transl Res. 2015 Oct 15;7(10):1699-711
26571833 - Vopr Onkol. 2015;61(4):619-23
26147886 - PLoS One. 2015 Jul 06;10(7):e0130839
21085763 - Arq Bras Endocrinol Metabol. 2010 Oct;54(7):591-602
24959290 - Oncol Lett. 2014 Jul;8(1):431-437
19047149 - Cancer Res. 2008 Dec 1;68(23):9712-22
28032598 - Oncotarget. 2017 Jan 31;8(5):7710-7721
26285644 - Breast Cancer Res Treat. 2015 Sep;153(2):323-35
16019138 - Cancer Lett. 2006 Jun 8;237(1):109-14
16952705 - J Urol. 2006 Oct;176(4 Pt 1):1631-5
28459203 - Tumour Biol. 2017 May;39(5):1010428317699130
25653112 - Br J Pharmacol. 2015 Jun;172(12):2974-90
28154783 - Cancer Biol Med. 2016 Dec;13(4):505-513
21475828 - Mol Med Rep. 2009 Mar-Apr;2(2):295-9
28173833 - J Exp Clin Cancer Res. 2017 Feb 7;36(1):26
26772821 - Int J Biochem Cell Biol. 2016 Mar;72 :18-26
25171477 - Cancer Biomark. 2014;14(5):353-9
28409493 - Croat Med J. 2017 Apr 14;58(2):96-104
23083134 - Mol Cancer. 2012 Oct 21;11:79
22848668 - PLoS One. 2012;7(7):e41942
24321071 - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Dec;29(12):1272-6
28771701 - FEBS Lett. 2017 Oct;591(19):3022-3041
28698008 - Gynecol Oncol. 2017 Oct;147(1):181-187
24569475 - Br J Cancer. 2014 Mar 18;110(6):1525-34
28018487 - Mol Cytogenet. 2016 Dec 16;9:90
14532921 - Rev Gastroenterol Peru. 2003 Jul-Sep;23(3):199-212
19966786 - Nature. 2010 Feb 4;463(7281):666-70
27027351 - Oncotarget. 2016 Apr 26;7(17 ):24495-509
25482303 - Breast Cancer Res. 2014 Oct 25;16(5):426
27036313 - Hum Pathol. 2016 Aug;54:37-46
25310198 - Oncol Rep. 2014 Dec;32(6):2760-8
26884894 - Int J Clin Exp Med. 2015 Nov 15;8(11):19840-9
25398149 - Ceska Gynekol. 2014 Aug;79(4):283-8
26017929 - Cell Cycle. 2015;14(16):2667-76
28926426 - Cancer J. 2017 Sep/Oct;23 (5):262-269
26261555 - Int J Clin Exp Pathol. 2015 Jun 01;8(6):6724-31
24738610 - Nutr Cancer. 2014;66(4):645-55
22581334 - J Biosci. 2012 Jun;37(2):289-94
27276368 - Curr Opin Gastroenterol. 2016 Jul;32(4):319-24
28750624 - J Biomed Sci. 2017 Jul 27;24(1):51
23386906 - J Cancer. 2013;4(1):66-83
24726064 - Biomed Pharmacother. 2014 May;68(4):471-5
25948792 - Oncotarget. 2015 Jun 30;6(18):16120-34
27999190 - Oncotarget. 2017 Jan 31;8(5):7740-7752
26233579 - J Cancer Res Clin Oncol. 2016 Mar;142(3):
References_xml – volume: 17
  start-page: 112
  year: 2015
  ident: bib0055
  article-title: Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers
  publication-title: Breast Cancer Res.
– volume: 25
  start-page: 119
  year: 2014
  end-page: 128
  ident: bib1190
  article-title: A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice
  publication-title: J. Am. Soc Nephrol.
– volume: 75
  start-page: 1009
  year: 2015
  end-page: 1019
  ident: bib0115
  article-title: Adipocyte-derived monocyte chemotactic protein-1 (MCP-1) promotes prostate cancer progression through the induction of MMP-2 activity
  publication-title: Prostate
– volume: 120
  start-page: 1592
  year: 2007
  end-page: 1596
  ident: bib0675
  article-title: Adipocytokines and breast cancer risk
  publication-title: Chin. Med. J. (Engl.)
– volume: 287
  start-page: 8598
  year: 2012
  end-page: 8612
  ident: bib0065
  article-title: Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways
  publication-title: J. Biol. Chem.
– volume: 24
  start-page: 272
  year: 2011
  end-page: 276
  ident: bib0500
  article-title: Adenocarcinoma versus squamous cell carcinoma: analysis of 306 patients in university hospital
  publication-title: Arq. Bras. Cir Dig.
– volume: 9
  start-page: 90
  year: 2016
  ident: bib0950
  article-title: Inherent variability of cancer-specific aneuploidy generates metastases
  publication-title: Mol. Cytogenet.
– volume: 147
  start-page: 847
  year: 2010
  end-page: 853
  ident: bib0635
  article-title: Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma
  publication-title: Surgery
– volume: 10
  start-page: S2
  year: 2008
  ident: bib0945
  article-title: Mechanisms of metastasis
  publication-title: Breast Cancer Res.
– volume: 58
  start-page: 96
  year: 2017
  end-page: 104
  ident: bib1015
  article-title: Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility
  publication-title: Croat. Med. J.
– volume: 5
  start-page: S3
  year: 2013
  end-page: 29
  ident: bib1185
  article-title: The impact of comorbidity on cancer survival: a review
  publication-title: Clin. Epidemiol.
– volume: 109
  start-page: 2257
  year: 2007
  end-page: 2267
  ident: bib0460
  article-title: Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy
  publication-title: Cancer
– volume: 7
  start-page: 24495
  year: 2016
  end-page: 24509
  ident: bib0150
  article-title: Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5
  publication-title: Oncotarget
– volume: 6
  start-page: 756
  year: 2014
  end-page: 767
  ident: bib0280
  article-title: STAT3 regulation the expression of VEGF-D in HGC-27 gastric cancer cell
  publication-title: Am. J. Transl. Res.
– volume: 172
  start-page: 2974
  year: 2015
  end-page: 2990
  ident: bib0825
  article-title: Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-(B pathway activation in human myometrial cells
  publication-title: Br. J. Pharmacol.
– volume: 69
  start-page: 601
  year: 2013
  end-page: 611
  ident: bib0980
  article-title: Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats
  publication-title: J. Physiol. Biochem.
– volume: 46
  start-page: 306
  year: 2013
  end-page: 310
  ident: bib0595
  article-title: Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer
  publication-title: Braz. J. Med. Biol. Res.
– volume: 27
  start-page: 1023
  year: 2009
  end-page: 1037
  ident: bib0550
  article-title: Cell adhesion molecules: role and clinical significance in cancer
  publication-title: Cancer Invest.
– volume: 11
  start-page: 79
  year: 2012
  ident: bib0480
  article-title: Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion
  publication-title: Mol. Cancer
– volume: 137
  start-page: 1841
  year: 2011
  end-page: 1848
  ident: bib0815
  article-title: Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis
  publication-title: J. Cancer Res Clin. Oncol.
– volume: 5
  start-page: 1140
  year: 2013
  end-page: 1162
  ident: bib0930
  article-title: Leptin's pro-angiogenic signature in breast cancer
  publication-title: Cancers (Basel)
– volume: 11
  start-page: 620
  year: 2014
  end-page: 625
  ident: bib0350
  article-title: PIK3CA gene amplification and PI3 K p110α protein expression in breast carcinoma
  publication-title: Int. J. Med. Sci.
– volume: 147
  start-page: 181
  year: 2017
  end-page: 187
  ident: bib1125
  article-title: Prognostic significance of tumor-associated macrophages in ovarian cancer: a meta-analysis
  publication-title: Gynecol. Oncol.
– volume: 13
  start-page: 505
  year: 2016
  end-page: 513
  ident: bib0890
  article-title: Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells
  publication-title: Cancer Biol
– volume: 34
  start-page: 974
  year: 2013
  end-page: 983
  ident: bib0540
  article-title: Leptin-mediated regulation of MT1-MMP localization is KIF1 B dependent and enhances gastric cancer cell invasion
  publication-title: Carcinogenesis
– volume: 12
  start-page: e0184451
  year: 2017
  ident: bib1160
  article-title: Stealth dissemination of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma
  publication-title: PLoS One
– volume: 179
  start-page: 147
  year: 2014
  end-page: 152
  ident: bib0405
  article-title: Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group
  publication-title: Eur. J. Obstet. Gynecol. Reprod. Biol.
– volume: 142
  start-page: 649
  year: 2016
  end-page: 657
  ident: bib0275
  article-title: The prognostic value of pSTAT3 in gastric cancer: a meta-analysis
  publication-title: J. Cancer Res Clin. Oncol.
– volume: 960
  start-page: 571
  year: 2017
  end-page: 606
  ident: bib0660
  article-title: Obesity-associated breast cancer: analysis of risk factors
  publication-title: Adv. Exp. Med. Biol.
– volume: 49
  start-page: 197
  year: 2016
  end-page: 206
  ident: bib0565
  article-title: Leptin promotes proliferation and metastasis of human gallbladder cancer through OB-Rb leptin receptor
  publication-title: Int. J. Oncol.
– volume: 38
  start-page: 1565
  year: 2014
  end-page: 1572
  ident: bib0040
  article-title: The potential role of leptin in the vascular remodeling associated with obesity
  publication-title: Int. J. Obes. (Lond.)
– volume: 1831
  start-page: 1533
  year: 2013
  end-page: 1541
  ident: bib0085
  article-title: Adipose tissue and adipocytes support tumorigenesis and metastasis
  publication-title: Biochim. Biophys. Acta
– volume: 67
  start-page: 333
  year: 2014
  end-page: 340
  ident: bib0465
  article-title: Phosphorylated Akt expression is a prognostic marker in early-stage non-small cell lung cancer
  publication-title: J. Clin. Pathol.
– volume: 170
  start-page: 198
  year: 2013
  end-page: 201
  ident: bib0870
  article-title: Leptin promotes human endometrial carcinoma cell proliferation by enhancing aromatase (P450arom) expression and estradiol formation
  publication-title: Eur. J. Obstet. Gynecol. Reprod. Biol.
– volume: 66
  start-page: 419
  year: 2012
  end-page: 424
  ident: bib0530
  article-title: Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients
  publication-title: Biomed. Pharmacother.
– volume: 69
  start-page: 329
  year: 2008
  end-page: 339
  ident: bib0770
  article-title: Integrin alpha(v)beta(3)-targeted cancer therapy
  publication-title: Drug Dev. Res.
– volume: 150
  start-page: 255
  year: 2015
  end-page: 263
  ident: bib0165
  article-title: Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1
  publication-title: Breast Cancer Res. Treat.
– volume: 33
  start-page: 2689
  year: 2015
  end-page: 2694
  ident: bib0160
  article-title: Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells
  publication-title: Oncol. Rep.
– volume: 22
  start-page: 50
  year: 2014
  end-page: 56
  ident: bib0345
  article-title: Analysis of PIK3CA mutations in breast cancer subtypes
  publication-title: Appl. Immunohistochem. Mol. Morphol.
– volume: 23
  start-page: 199
  year: 2003
  end-page: 212
  ident: bib0520
  article-title: Classification of stomach adenocarcinomas
  publication-title: Rev. Gastroenterol. Peru
– volume: 25
  start-page: 770
  year: 2015
  end-page: 778
  ident: bib0910
  article-title: Leptin inhibits the apoptosis of endometrial carcinoma cells through activation of the nuclear factor κB-inducing kinase/IκB kinase pathway
  publication-title: Int. J. Gynecol. Cancer
– volume: 140
  start-page: 57
  year: 2015
  end-page: 63
  ident: bib1000
  article-title: Leptin resistance in obesity: an epigenetic landscape
  publication-title: Life Sci.
– volume: 176
  start-page: 1631
  year: 2006
  end-page: 1635
  ident: bib0780
  article-title: Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma
  publication-title: J. Urol.
– volume: 151
  start-page: 453
  year: 2015
  end-page: 463
  ident: bib0990
  article-title: Body mass index associated with genome-wide methylation in breast tissue
  publication-title: Breast Cancer Res. Treat.
– volume: 36
  start-page: 358
  year: 2016
  end-page: 363
  ident: bib0145
  article-title: Interaction between breast cancer cells and adipose tissue cells derived from fat grafting
  publication-title: Aesthet. Surg. J.
– volume: 6
  start-page: 21100
  year: 2015
  end-page: 21119
  ident: bib0080
  article-title: Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
  publication-title: Oncotarget
– volume: 6
  start-page: 39
  year: 2015
  end-page: 47
  ident: bib0185
  article-title: Adipocyte activation of cancer stem cell signaling in breast cancer
  publication-title: World J. Biol Chem.
– volume: 7
  start-page: 5940
  year: 2014
  end-page: 5949
  ident: bib0450
  article-title: REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 49
  start-page: 98
  year: 2016
  end-page: 109
  ident: bib0475
  article-title: Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma
  publication-title: Med. Mol. Morphol.
– volume: 67
  start-page: 2497
  year: 2007
  end-page: 2507
  ident: bib1085
  article-title: Concomitant activation of the JAK/STAT, PI3 K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
  publication-title: Cancer Res.
– volume: 7
  start-page: 144
  year: 2016
  end-page: 149
  ident: bib0105
  article-title: Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer
  publication-title: Biochem. Biophys. Rep.
– volume: 10
  start-page: e0119348
  year: 2015
  ident: bib0170
  article-title: Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2
  publication-title: PLoS One
– volume: 33
  start-page: 11
  year: 2017
  end-page: 20
  ident: bib1025
  article-title: Underlying mechanisms for distant metastasis − Molecular biology
  publication-title: Visc. Med.
– volume: 7
  start-page: 2346
  year: 2016
  end-page: 2359
  ident: bib0135
  article-title: Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation
  publication-title: J. Cancer
– volume: 7
  start-page: e41942
  year: 2012
  ident: bib1165
  article-title: Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer
  publication-title: PLoS One
– volume: 15
  start-page: 245
  year: 2014
  end-page: 246
  ident: bib0390
  article-title: Crosstalk between ERK, AKT, and cell survival
  publication-title: Cancer Biol. Ther.
– volume: 39
  year: 2017
  ident: bib1090
  article-title: Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma
  publication-title: Tumor Biol.
– volume: 36
  start-page: 26
  year: 2017
  ident: bib0130
  article-title: Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer
  publication-title: J. Exp. Clin. Cancer Res.
– volume: 37
  start-page: 289
  year: 2012
  end-page: 294
  ident: bib0005
  article-title: Adipokine leptin in obesity-related pathology of breast cancer
  publication-title: J. Biosci.
– volume: 6
  start-page: e21467
  year: 2011
  ident: bib0710
  article-title: Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer
  publication-title: PLoS One
– volume: 49
  start-page: 473
  year: 2013
  end-page: 478
  ident: bib1150
  article-title: Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk
  publication-title: In Vitro Cell. Dev. Biol. Anim.
– volume: 45
  start-page: 189
  year: 2012
  end-page: 197
  ident: bib0050
  article-title: Obesity and breast cancer: a clinical biochemistry perspective
  publication-title: Clin. Biochem.
– volume: 14
  start-page: 353
  year: 2014
  end-page: 359
  ident: bib0650
  article-title: Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology in endometrial cancer
  publication-title: Cancer Biomark.
– volume: 226
  start-page: 1274
  year: 2011
  end-page: 1282
  ident: bib0760
  article-title: Leptin increases motility and integrin up-regulation in human prostate cancer cells
  publication-title: J. Cell. Physiol.
– volume: 12
  start-page: e0170675
  year: 2017
  ident: bib1065
  article-title: A dangerous liaison: leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells
  publication-title: PLoS One
– volume: 38
  start-page: 326
  year: 2012
  end-page: 336
  ident: bib0200
  article-title: Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish
  publication-title: Peptides
– volume: 11
  start-page: 1946
  year: 2015
  end-page: 1954
  ident: bib0400
  article-title: The PI3 K/AKT/mTOR interactive pathway
  publication-title: Mol. Biosyst.
– volume: 6
  start-page: 2112
  year: 2013
  end-page: 2120
  ident: bib0430
  article-title: Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 2015
  start-page: 253519
  year: 2015
  ident: bib0670
  article-title: Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal Saudi females and their possible diagnostic and predictive implications as novel biomarkers
  publication-title: Dis. Markers
– volume: 153
  start-page: 323
  year: 2015
  end-page: 335
  ident: bib0155
  article-title: Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells
  publication-title: Breast Cancer Res. Treat.
– volume: 188
  start-page: 560
  year: 2004
  end-page: 565
  ident: bib1040
  article-title: Leptin induces cell migration and the expression of growth factors in human prostate cancer cells
  publication-title: Am. J. Surg.
– volume: 30
  start-page: 294
  year: 2017
  end-page: 306
  ident: bib0790
  article-title: Obesity and melanoma: could fat be fueling malignancy?
  publication-title: Pigment Cell Melanoma Res.
– volume: 115
  start-page: 3457
  year: 2009
  end-page: 3467
  ident: bib0470
  article-title: Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma
  publication-title: Cancer
– volume: 36
  start-page: 283
  year: 2006
  end-page: 293
  ident: bib0420
  article-title: Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas
  publication-title: Ann. Clin. Lab. Sci.
– volume: 50
  start-page: 753
  year: 2017
  end-page: 767
  ident: bib0250
  article-title: Regulation of EMT by STAT3 in gastrointestinal cancer (review)
  publication-title: Int. J. Oncol.
– volume: 199
  start-page: 221
  year: 2008
  end-page: 233
  ident: bib0750
  article-title: Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression
  publication-title: J. Endocrinol.
– volume: 66
  start-page: 645
  year: 2014
  end-page: 655
  ident: bib0850
  article-title: Leptin induces a proliferative response in breast cancer cells but not in normal breast cells
  publication-title: Nutr. Cancer
– volume: 21
  start-page: 792
  year: 2015
  end-page: 802
  ident: bib0030
  article-title: Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway
  publication-title: Mol. Hum. Reprod.
– volume: 30
  start-page: 566
  year: 2009
  end-page: 574
  ident: bib0765
  article-title: Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor
  publication-title: Carcinogenesis
– volume: 23
  start-page: 603
  year: 2013
  end-page: 611
  ident: bib0970
  article-title: Transcriptional control of cancer metastasis
  publication-title: Trends Cell Biol.
– volume: 36
  start-page: 6813
  year: 2015
  end-page: 6821
  ident: bib0885
  article-title: ObRb downregulation increases breast cancer cell sensitivity to tamoxifen
  publication-title: Tumour Biol.
– volume: 7
  start-page: 86075
  year: 2016
  end-page: 86086
  ident: bib0905
  article-title: Adipocytes secreted leptin is a pro-tumor factor for survival of multiple myeloma under chemotherapy
  publication-title: Oncotarget
– volume: 72
  start-page: 18
  year: 2016
  end-page: 26
  ident: bib0835
  article-title: Leptin regulates energy metabolism in MCF-7 breast cancer cells
  publication-title: Int. J. Biochem. Cell Biol.
– volume: 18
  start-page: 43
  year: 2013
  end-page: 73
  ident: bib1155
  article-title: On the origin of cancer metastasis
  publication-title: Crit. Rev. Oncog.
– volume: 18
  start-page: 2519
  year: 2014
  end-page: 2529
  ident: bib0665
  article-title: Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancer
  publication-title: J. Cell. Mol. Med.
– volume: 208
  start-page: 398
  year: 2012
  end-page: 404
  ident: bib0485
  article-title: pERK activation in esophageal carcinomas: clinicopathological associations
  publication-title: Pathol. Res. Pract.
– volume: 11
  start-page: C56
  year: 2015
  end-page: C58
  ident: bib0320
  article-title: Expression of signal transducer and activator of transcription 3 in breast cancer and its clinical significance
  publication-title: J. Cancer Res
– volume: 32
  start-page: 319
  year: 2016
  end-page: 324
  ident: bib0495
  article-title: Determination of risk for Barrett's esophagus and esophageal adenocarcinoma
  publication-title: Curr. Opin. Gastroenterol.
– volume: 223
  year: 2014
  ident: bib0215
  article-title: 20 years of leptin: insights into signaling assemblies of the leptin receptor
  publication-title: J. Endocrinol.
– volume: 23
  start-page: 262
  year: 2017
  end-page: 269
  ident: bib0965
  article-title: Epigenetics and precision oncology
  publication-title: Cancer J.
– volume: 385
  start-page: 90
  year: 2015
  end-page: 101
  ident: bib0210
  article-title: Exploring the structure and conformational landscape of human leptin. A molecular dynamics approach
  publication-title: J. Theor. Biol.
– volume: 34
  start-page: 2041
  year: 2013
  end-page: 2051
  ident: bib0020
  article-title: Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
  publication-title: Tumour Biol.
– volume: 393
  start-page: 7
  year: 2006
  end-page: 20
  ident: bib0225
  article-title: Intracellular signalling pathways activated by leptin
  publication-title: Biochem. J.
– volume: 121
  start-page: 10
  year: 2015
  end-page: 15
  ident: bib0855
  article-title: Leptin influences estrogen metabolism and accelerates prostate cell proliferation
  publication-title: Life Sci.
– year: 2017
  ident: bib0995
  article-title: miRNAs in nutrition, obesity, and cancer: the biology of miRNAs in metabolic disorders and its relationship with cancer development
  publication-title: Mol. Nutr. Food Res.
– volume: 26
  start-page: 1265
  year: 2011
  end-page: 1271
  ident: bib0645
  article-title: Leptin enhances migration of human papillary thyroid cancer cells through the PI3 K/AKT and MEK/ERK signaling pathways
  publication-title: Oncol. Rep.
– volume: 68
  start-page: 1383
  year: 2014
  end-page: 1391
  ident: bib0985
  article-title: DNA methylation in obesity
  publication-title: Postepy Hig Med. Dosw. (Online)
– volume: 31
  start-page: 2493
  year: 2014
  end-page: 2498
  ident: bib0900
  article-title: Leptin-induced adhesion and invasion in colorectal cancer cell lines
  publication-title: Oncol. Rep.
– volume: 1845
  start-page: 136
  year: 2014
  end-page: 154
  ident: bib0240
  article-title: Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
  publication-title: Biochim. Biophys. Acta
– volume: 84
  start-page: 14
  year: 2016
  end-page: 21
  ident: bib0095
  article-title: Omental adipocytes enhance the invasiveness of gastric cancer cells by oleic acid-induced activation of the PI3K-Akt signaling pathway
  publication-title: Int. J. Biochem. Cell Biol.
– volume: 29
  start-page: 641
  year: 2010
  end-page: 653
  ident: bib0685
  article-title: Obesity and breast cancer: status of leptin and adiponectin in pathological processes
  publication-title: Cancer Metastasis Rev.
– volume: 138
  start-page: 197
  year: 2013
  end-page: 210
  ident: bib0140
  article-title: Adipocytes: impact on tumor growth and potential sites for therapeutic intervention
  publication-title: Pharmacol. Ther.
– volume: 4
  start-page: 66
  year: 2013
  end-page: 83
  ident: bib0015
  article-title: The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas
  publication-title: J. Cancer
– volume: 9
  start-page: 350
  year: 2014
  end-page: 354
  ident: bib1110
  article-title: Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway
  publication-title: Mol. Med. Rep.
– volume: 142
  start-page: 593
  year: 2014
  end-page: 598
  ident: bib0915
  article-title: Association between obesity and ovarian cancer
  publication-title: Rev. Med. Chil.
– volume: 16
  start-page: 1042
  year: 2015
  end-page: 1054
  ident: bib0615
  article-title: Adiposity and risk of thyroid cancer: a systematic review and meta-analysis
  publication-title: Obes. Rev.
– volume: 95
  start-page: e3073
  year: 2016
  ident: bib0785
  article-title: Elevated serum leptin levels are associated with an increased risk of sentinel lymph node metastasis in cutaneous melanoma
  publication-title: Medicine (Baltimore)
– volume: 36
  start-page: 839
  year: 2014
  end-page: 843
  ident: bib0510
  article-title: Expression of leptin and adiponectin in esophageal squamous cell carcinoma and their clinical significance
  publication-title: Zhonghua Zhong Liu Za Zhi (Chinese Journal of Oncology)
– volume: 8
  start-page: e2593
  year: 2017
  ident: bib0100
  article-title: Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer
  publication-title: Cell Death Dis.
– volume: 9
  start-page: 689
  year: 2015
  end-page: 703
  ident: bib0800
  article-title: Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: role of adipokines
  publication-title: Mol. Oncol.
– volume: 237
  start-page: 109
  year: 2006
  end-page: 114
  ident: bib0680
  article-title: Serum adiponectin and leptin levels in Taiwanese breast cancer patients
  publication-title: Cancer Lett.
– volume: 14
  start-page: 2667
  year: 2015
  end-page: 2676
  ident: bib0830
  article-title: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation
  publication-title: Cell Cycle
– volume: 8
  start-page: 8226
  year: 2017
  end-page: 8238
  ident: bib0325
  article-title: Genomic regulation of invasion by STAT3 in triple negative breast cancer
  publication-title: Oncotarget
– volume: 10
  start-page: 6865
  year: 2004
  end-page: 6871
  ident: bib0445
  article-title: Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
  publication-title: Clin. Cancer Res.
– volume: 591
  start-page: 3022
  year: 2017
  end-page: 3041
  ident: bib1115
  article-title: Cellular metabolism of tumor-associated macrophages − functional impact and consequences
  publication-title: FEBS. Lett.
– volume: 305
  start-page: F871
  year: 2013
  end-page: 880
  ident: bib0045
  article-title: Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity
  publication-title: Am. J. Physiol. Renal Physiol.
– volume: 8
  start-page: 431
  year: 2014
  end-page: 437
  ident: bib0285
  article-title: STAT3, p-STAT3 and HIF-1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma
  publication-title: Oncol. Lett.
– volume: 17
  start-page: 165
  year: 2013
  end-page: 171
  ident: bib0490
  article-title: High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer
  publication-title: Ann. Diagn. Pathol.
– volume: 17
  start-page: 849
  year: 2015
  end-page: 861
  ident: bib0745
  article-title: Breast cancer cell colonization of the human bone marrow adipose tissue niche
  publication-title: Neoplasia
– volume: 2
  start-page: 295
  year: 2009
  end-page: 299
  ident: bib0925
  article-title: Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis
  publication-title: Mol. Med. Rep.
– volume: 22
  start-page: 1317
  year: 2007
  end-page: 1321
  ident: bib0525
  article-title: Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer
  publication-title: J. Gastroenterol. Hepatol
– volume: 469
  start-page: 35
  year: 2016
  end-page: 43
  ident: bib0360
  article-title: Mutation of genes of the PI3 K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness
  publication-title: Virchows Arch.
– volume: 45
  start-page: 536
  year: 2013
  end-page: 545
  ident: bib0895
  article-title: The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation
  publication-title: Int. J. Biochem. Cell Biol.
– volume: 2
  start-page: 165
  year: 2013
  end-page: 169
  ident: bib0190
  article-title: Local adipocytes enable estrogen-dependent breast cancer growth: role of leptin and aromatase
  publication-title: Adipocyte
– volume: 136
  start-page: 258
  year: 2015
  end-page: 270
  ident: bib1145
  article-title: High-fat diet-induced obesity increases lymphangiogenesis and lymph node metastasis in the B16F10 melanoma allograft model: roles of adipocytes and M2-macrophages
  publication-title: Int. J. Cancer
– volume: 42
  start-page: 1113
  year: 2013
  end-page: 1119
  ident: bib0840
  article-title: Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3 K/Akt signaling pathways
  publication-title: Int. J. Oncol.
– volume: 122
  start-page: 3078
  year: 2009
  end-page: 3081
  ident: bib0695
  article-title: Overexpression of leptin and leptin receptors in breast cancer positively correlates with clinicopathological features
  publication-title: Chin. Med. J. (Engl.)
– volume: 68
  start-page: 471
  year: 2014
  end-page: 475
  ident: bib0380
  article-title: Clinicopathological significance of PI3 K, Akt and survivin expression in gastric cancer
  publication-title: Biomed. Pharmacother.
– volume: 16
  start-page: 400
  year: 2016
  ident: bib0365
  article-title: Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review
  publication-title: BMC. Cancer
– volume: 29
  start-page: 1596
  year: 2008
  end-page: 1602
  ident: bib0935
  article-title: Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma
  publication-title: Peptides
– volume: 5
  start-page: e267
  year: 2016
  ident: bib0335
  article-title: Constitutively activated PI3 K accelerates tumor initiation and modifies histopathology of breast cancer
  publication-title: Oncogenesis
– volume: 13
  start-page: 3125
  year: 2007
  end-page: 3132
  ident: bib0810
  article-title: Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma
  publication-title: Clin. Cancer Res.
– volume: 8
  start-page: 30576
  year: 2017
  end-page: 30586
  ident: bib1120
  article-title: Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature
  publication-title: Oncotarget
– volume: 16
  start-page: 201
  year: 2014
  ident: bib0340
  article-title: PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data
  publication-title: Breast Cancer Res.
– year: 2016
  ident: bib1170
  article-title: Histology
– volume: 285
  start-page: 36551
  year: 2010
  end-page: 36560
  ident: bib0060
  article-title: Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
  publication-title: J. Biol. Chem.
– volume: 110
  start-page: 1801
  year: 2014
  end-page: 1810
  ident: bib0545
  article-title: Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration
  publication-title: Br. J. Cancer
– volume: 6
  start-page: 16120
  year: 2015
  end-page: 16134
  ident: bib0600
  article-title: Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production
  publication-title: Oncotarget
– volume: 75
  start-page: 917
  year: 2015
  end-page: 922
  ident: bib0310
  article-title: Activated STAT3 correlates with prognosis of non-small cell lung cancer and indicates new anticancer strategies
  publication-title: Cancer Chemother. Pharmacol.
– volume: 71
  start-page: 345
  year: 2005
  end-page: 372
  ident: bib0205
  article-title: Leptin: structure, function and biology
  publication-title: Vitam. Horm.
– volume: 463
  start-page: 666
  year: 2010
  end-page: 670
  ident: bib0975
  article-title: Large, rare chromosomal deletions associated with severe early-onset obesity
  publication-title: Nature
– volume: 57
  start-page: 454
  year: 2009
  end-page: 464
  ident: bib1105
  article-title: Leptin induces migration and invasion of glioma cells through MMP-13 production
  publication-title: Glia
– volume: 32
  start-page: 104
  year: 2017
  end-page: 114
  ident: bib1045
  article-title: RhoA/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells
  publication-title: Cell. Signal.
– volume: 39
  start-page: 1588
  year: 2016
  end-page: 1596
  ident: bib1135
  article-title: Diverse macrophages polarization in tumor microenvironment
  publication-title: Arch. Pharm. Res.
– volume: 79
  start-page: 283
  year: 2014
  end-page: 288
  ident: bib0355
  article-title: Correlation between the incidence of PIK3CA mutations in breast cancer and histopathological characteristics of the tumor
  publication-title: Ceska Gynekol.
– volume: 43
  start-page: 394
  year: 2013
  end-page: 403
  ident: bib0880
  article-title: Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells
  publication-title: Endocrine
– volume: 54
  start-page: 37
  year: 2016
  end-page: 46
  ident: bib0440
  article-title: Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations
  publication-title: Hum. Pathol.
– volume: 16
  start-page: 419
  year: 2016
  ident: bib0735
  article-title: Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells
  publication-title: BMC Cancer
– volume: 61
  start-page: 619
  year: 2015
  end-page: 623
  ident: bib0570
  article-title: Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis
  publication-title: Vopr. Onkol.
– volume: 54
  start-page: 591
  year: 2010
  end-page: 602
  ident: bib0330
  article-title: The PI3 K signaling pathway mediates the biological effects of leptin
  publication-title: Arq. Bras. Endocrinol. Metabol.
– volume: 60
  start-page: 151
  year: 2017
  end-page: 160
  ident: bib1180
  article-title: Leptin resistance elicits depressive-like behaviors in rats
  publication-title: Brain Behav. Immun.
– volume: 6
  start-page: 11203
  year: 2015
  end-page: 11215
  ident: bib0505
  article-title: Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion
  publication-title: Oncotarget
– volume: 17
  start-page: 179
  year: 2010
  end-page: 189
  ident: bib0590
  article-title: Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways
  publication-title: Endocr. Relat. Cancer
– volume: 5
  start-page: 378
  year: 2015
  end-page: 389
  ident: bib0610
  article-title: HIF-1α pathway: role, regulation and intervention for cancer therapy, Acta Pharm
  publication-title: Sin. B
– volume: 3
  start-page: 18
  year: 2017
  ident: bib0795
  article-title: Integrative analysis of pathway deregulation in obesity
  publication-title: N. P. J. Syst. Biol. Appl.
– volume: 35
  start-page: 166
  year: 2016
  ident: bib1100
  article-title: Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2
  publication-title: J. Exp. Clin. Cancer Res.
– volume: 217
  start-page: 283
  year: 2013
  end-page: 290
  ident: bib1175
  article-title: A superactive leptin antagonist alters metabolism and locomotion in high-leptin mice
  publication-title: J. Endocrinol.
– volume: 12
  start-page: 35
  year: 2012
  ident: bib0730
  article-title: Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
  publication-title: BMC Cancer
– volume: 38
  start-page: 900
  year: 2017
  end-page: 909
  ident: bib0960
  article-title: Intratumor heterogeneity predicts metastasis of triple-negative breast cancer
  publication-title: Carcinogenesis
– volume: 60
  start-page: 241
  year: 2011
  end-page: 244
  ident: bib0585
  article-title: Expression and biological significance of leptin, leptin receptor, VEGF, and CD34 in colorectal carcinoma
  publication-title: Cell Biochem. Biophys.
– volume: 10
  start-page: e0126686
  year: 2015
  ident: bib1070
  article-title: Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells
  publication-title: PLoS One
– volume: 21
  start-page: 165
  year: 2013
  end-page: 171
  ident: bib0070
  article-title: Leptin promotes metastasis by inducing an epithelial-mesenchymal transition in A549 lung cancer cells
  publication-title: Oncol. Res.
– volume: 16
  start-page: 4986
  year: 2010
  end-page: 4991
  ident: bib0375
  article-title: Up-regulation of PIK3CA promotes metastasis in gastric carcinoma
  publication-title: World J. Gastroenterol.
– start-page: 67
  year: 2008
  end-page: 88
  ident: bib0940
  article-title: The angiogenic switch in tumorigenesis
  publication-title: Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy
– volume: 10
  start-page: e0130839
  year: 2015
  ident: bib0515
  article-title: Implication of leptin-signaling proteins and epstein-barr virus in gastric carcinomas
  publication-title: PLoS One
– volume: 8
  start-page: 546
  year: 2015
  end-page: 557
  ident: bib0270
  article-title: Prognostic and clinical significance of STAT3 and MMP9 in patients with gastric cancer: a meta-analysis of a Chinese cohort
  publication-title: Int. J Clin. Exp. Med.
– volume: 7
  start-page: 65441
  year: 2016
  end-page: 65453
  ident: bib0740
  article-title: Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages
  publication-title: Oncotarget
– volume: 33
  start-page: 1872
  year: 2015
  end-page: 1882
  ident: bib0260
  article-title: STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cells
  publication-title: Oncol. Rep.
– volume: 29
  start-page: 2291
  year: 2013
  end-page: 2296
  ident: bib0920
  article-title: Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer
  publication-title: Oncol. Rep.
– volume: 26
  start-page: 197
  year: 2009
  end-page: 204
  ident: bib0715
  article-title: Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
  publication-title: Clin. Exp. Metastasis
– volume: 177
  start-page: 3133
  year: 2010
  end-page: 3144
  ident: bib0705
  article-title: Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo
  publication-title: Am. J. Pathol.
– volume: 24
  start-page: 190
  year: 2014
  end-page: 199
  ident: bib0620
  article-title: Obesity and thyroid cancer: a clinical update
  publication-title: Thyroid
– volume: 5
  start-page: 797
  year: 2013
  end-page: 800
  ident: bib0630
  article-title: Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
  publication-title: Oncol. Lett.
– volume: 5
  start-page: 135
  year: 2016
  end-page: 138
  ident: bib1130
  article-title: The role of tumour-associated macrophages in bone metastasis
  publication-title: J. Bone Oncol.
– volume: 6
  start-page: 18674
  year: 2015
  end-page: 18682
  ident: bib0415
  article-title: High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis
  publication-title: Oncotarget
– volume: 16
  start-page: 2495
  year: 2015
  end-page: 2499
  ident: bib0435
  article-title: Expression and prognostic role of MEKK3 and pERK in patients with renal clear cell carcinoma
  publication-title: Asian Pac. J Cancer Prev.
– volume: 29
  start-page: 1272
  year: 2013
  end-page: 1276
  ident: bib1095
  article-title: The effect of leptin and its mechanisms on the migration and invasion of human breast cancer MCF-7 cells
  publication-title: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (Chinese Journal of Cellular and Molecular Immunology)
– volume: 8
  start-page: 7710
  year: 2017
  end-page: 7721
  ident: bib0265
  article-title: STAT3 overexpression promotes metastasis in intrahepatic cholangiocarcinoma and correlates negatively with surgical outcome
  publication-title: Oncotarget
– volume: 17
  start-page: 191
  year: 2010
  end-page: 202
  ident: bib0640
  article-title: Leptin-R and its association with PI3 K/AKT signaling pathway in papillary thyroid carcinoma
  publication-title: Endocr. Relat. Cancer
– volume: 32
  start-page: 2760
  year: 2014
  end-page: 2768
  ident: bib0315
  article-title: Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer
  publication-title: Oncol. Rep.
– volume: 62
  start-page: 2096
  year: 2014
  end-page: 2109
  ident: bib0395
  article-title: Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation
  publication-title: Glia
– volume: 48
  start-page: 2479
  year: 2016
  end-page: 2487
  ident: bib0720
  article-title: Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion
  publication-title: Int. J. Oncol.
– volume: 8
  start-page: 19840
  year: 2015
  end-page: 19849
  ident: bib0230
  article-title: Leptin and its receptor in hematologic malignancies
  publication-title: Int. J. Clin. Exp. Med.
– volume: 68
  start-page: 9712
  year: 2008
  end-page: 9722
  ident: bib0755
  article-title: Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor
  publication-title: Cancer Res.
– volume: 8
  start-page: 7740
  year: 2017
  end-page: 7752
  ident: bib0860
  article-title: Leptin-Notch signaling axis is involved in pancreatic cancer progression
  publication-title: Oncotarget
– volume: 354
  start-page: 172
  year: 2014
  end-page: 180
  ident: bib0605
  article-title: Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells
  publication-title: Cancer Lett.
– volume: 12
  start-page: e0178454
  year: 2017
  ident: bib1075
  article-title: Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer
  publication-title: PLoS One
– volume: 68
  start-page: 6752
  year: 2008
  end-page: 6761
  ident: bib1035
  article-title: Leptin enhances cholangiocarcinoma cell growth
  publication-title: Cancer Res.
– year: 2017
  ident: bib1055
  article-title: Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2
  publication-title: Cell. Oncol (Dordr.)
– volume: 11
  start-page: e0166172
  year: 2016
  ident: bib1030
  article-title: APPL1-mediating leptin signaling contributes to proliferation and migration of cancer cells
  publication-title: PLoS One
– volume: 46
  start-page: 1535
  year: 2015
  end-page: 1542
  ident: bib1080
  article-title: Long term exposure to leptin enhances the growth of prostate cancer cells
  publication-title: Int. J. Oncol.
– volume: 12
  start-page: 5517
  year: 2006
  end-page: 5522
  ident: bib0535
  article-title: Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer
  publication-title: World J. Gastroenterol.
– volume: 37
  start-page: 91
  year: 2012
  end-page: 101
  ident: bib0580
  article-title: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3 K/Akt/mTOR signalling pathway
  publication-title: J. Biosci.
– volume: 16
  start-page: 1220
  year: 2015
  end-page: 1230
  ident: bib0075
  article-title: Activation of IL-8 via PI3 K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells
  publication-title: Cancer Biol. Ther.
– volume: 18
  start-page: 3745
  year: 2012
  end-page: 3751
  ident: bib0385
  article-title: PI3 K expression and PIK3CA mutations are related to colorectal cancer metastases
  publication-title: World J. Gastroenterol.
– volume: 17
  start-page: 79
  year: 2014
  end-page: 87
  ident: bib0035
  article-title: Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects
  publication-title: Horm. Mol. Biol. Clin. Investig.
– volume: 11
  start-page: e0160125
  year: 2016
  ident: bib0295
  article-title: The role of p-STAT3 as a prognostic and clinicopathological marker in colorectal cancer: a systematic review and meta-analysis
  publication-title: PLoS One
– volume: 73
  start-page: 366
  year: 2011
  end-page: 374
  ident: bib0305
  article-title: JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer
  publication-title: Lung Cancer
– year: 2017
  ident: bib1050
  article-title: Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways
  publication-title: J. Cell Biochem
– volume: 10
  start-page: 577
  year: 2009
  end-page: 584
  ident: bib0220
  article-title: Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function
  publication-title: Curr. Protein Pept. Sci.
– volume: 6
  start-page: 7166
  year: 2015
  end-page: 7181
  ident: bib0875
  article-title: Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis
  publication-title: Oncotarget
– volume: 10
  start-page: 4325
  year: 2004
  end-page: 4331
  ident: bib0690
  article-title: Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
  publication-title: Clin. Cancer Res.
– volume: 18
  start-page: 269
  year: 2009
  end-page: 277
  ident: bib0775
  article-title: Role of the adiponectin leptin ratio in prostate cancer
  publication-title: Oncol. Res.
– volume: 6
  start-page: 21782
  year: 2016
  ident: bib0025
  article-title: Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
  publication-title: Sci. Rep.
– volume: 64
  start-page: 3201
  year: 2007
  end-page: 3218
  ident: bib0010
  article-title: Molecular basis of invasion in breast cancer
  publication-title: Cell. Mol. Life Sci.
– volume: 27
  start-page: 581
  year: 2010
  end-page: 590
  ident: bib0820
  article-title: Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice
  publication-title: Clin. Exp. Metastasis.
– volume: 8
  start-page: 75389
  year: 2017
  end-page: 75399
  ident: bib0655
  article-title: The association between obesity related adipokines and risk of breast cancer: a systematic review and meta-analysis
  publication-title: Oncotarget
– volume: 24
  start-page: 51
  year: 2017
  ident: bib0845
  article-title: Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells
  publication-title: J. Biomed. Sci.
– volume: 17
  start-page: e11
  year: 2017
  end-page: e18
  ident: bib0125
  article-title: Invasive breast cancer preferably and predominantly occurs at the interface between fibroglandular and adipose tissue
  publication-title: Clin. Breast Cancer
– volume: 14
  start-page: 157
  year: 2012
  end-page: 165
  ident: bib0575
  article-title: Metabolic syndrome and leptin are associated with adverse pathological features in male colorectal cancer patients
  publication-title: Colorectal Dis.
– volume: 7
  start-page: 253
  year: 2015
  end-page: 265
  ident: bib0090
  article-title: Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment
  publication-title: World J. Stem Cells
– volume: 28
  start-page: 285
  year: 2013
  end-page: 292
  ident: bib1005
  article-title: Metastasis suppressor genes
  publication-title: Histol. Histopathol.
– volume: 8
  start-page: 2295
  year: 2014
  end-page: 2302
  ident: bib0235
  article-title: Leptin signaling molecular actions and drug target in hepatocellular carcinoma
  publication-title: Drug Des. Devel. Ther.
– volume: 16
  start-page: 426
  year: 2014
  ident: bib0700
  article-title: Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway
  publication-title: Breast Cancer Res.
– volume: 8
  start-page: 6724
  year: 2015
  end-page: 6731
  ident: bib0410
  article-title: Expression of CD44 in pancreatic cancer and its significance
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 123
  start-page: 373
  year: 2015
  end-page: 382
  ident: bib0255
  article-title: Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β
  publication-title: APMIS
– volume: 43
  start-page: 857
  year: 2014
  end-page: 866
  ident: bib0805
  article-title: Type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies
  publication-title: Iran. J. Public Health
– volume: 198
  start-page: 2927
  year: 2017
  end-page: 2934
  ident: bib1140
  article-title: IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity
  publication-title: J. Immunol.
– volume: 17
  start-page: 594
  year: 2014
  end-page: 597
  ident: bib0290
  article-title: Expressions of STAT3, p-STAT3 and E-cadherin in colorectal cancer and clinical implications
  publication-title: Zhonghua Wei Chang Wai Ke Za Zhi (Chinese Journal of Gastrointestinal Surgery)
– volume: 110
  start-page: 1525
  year: 2014
  end-page: 1534
  ident: bib0555
  article-title: Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
  publication-title: Br. J. Cancer
– volume: 15
  start-page: 133
  year: 2017
  ident: bib0955
  article-title: The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome
  publication-title: BMC. Med.
– volume: 39
  start-page: 1085
  year: 2016
  end-page: 1099
  ident: bib0245
  article-title: Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment
  publication-title: Arch. Pharm. Res.
– volume: 12
  start-page: 50
  year: 2012
  ident: bib0370
  article-title: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
  publication-title: BMC. Cancer
– volume: 7
  start-page: 1699
  year: 2015
  end-page: 1711
  ident: bib0725
  article-title: Regulation of epithelial-mesenchymal transition by tumor-associated macrophages in cancer
  publication-title: Am. J. Transl. Res.
– volume: 10
  start-page: e0123217
  year: 2015
  ident: bib0110
  article-title: Adipocyte secreted factors enhance aggressiveness of prostate carcinoma cells
  publication-title: PLoS One
– volume: 32
  start-page: 550
  year: 2011
  end-page: 570
  ident: bib0175
  article-title: Paracrine and endocrine effects of adipose tissue on cancer development and progression
  publication-title: Endocr Rev.
– volume: 1
  start-page: 245
  year: 2012
  end-page: 265
  ident: bib0195
  article-title: Leptin signaling and Alzheimer's disease
  publication-title: Am. J. Neurodegener. Dis.
– volume: 117
  start-page: 1399
  year: 2011
  end-page: 1408
  ident: bib0455
  article-title: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers
  publication-title: Cancer
– volume: 32
  start-page: 9870
  year: 2012
  end-page: 9877
  ident: bib1020
  article-title: TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity
  publication-title: J. Neurosci.
– volume: 127
  start-page: 407
  year: 2011
  end-page: 416
  ident: bib0425
  article-title: Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer
  publication-title: Breast Cancer Res. Treat.
– volume: 18
  start-page: 413
  year: 2011
  end-page: 428
  ident: bib1060
  article-title: Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells
  publication-title: Endocr. Relat. Cancer
– volume: 71
  start-page: 2455
  year: 2011
  end-page: 2465
  ident: bib0180
  article-title: Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion
  publication-title: Cancer Res.
– volume: 106
  start-page: 232
  year: 2017
  end-page: 241
  ident: bib0865
  article-title: Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells
  publication-title: Food Chem Toxicol.
– volume: 40
  start-page: 311
  year: 2014
  end-page: 317
  ident: bib0300
  article-title: A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer
  publication-title: Eur. J. Surg. Oncol.
– volume: 19
  start-page: 1122
  year: 2015
  end-page: 1132
  ident: bib0560
  article-title: A novel leptin antagonist peptide inhibits breast cancer growth in vitro and in vivo
  publication-title: J. Cell. Mol. Med.
– volume: 83
  start-page: 261
  year: 2015
  end-page: 267
  ident: bib0625
  article-title: Expression of leptin and its receptor in thyroid carcinoma: distinctive prognostic significance in different subtypes
  publication-title: Clin. Endocrinol. (Oxf.)
– volume: 31
  start-page: 32
  year: 2012
  ident: bib0120
  article-title: Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro
  publication-title: J. Exp. Clin. Cancer Res.
– volume: 174
  start-page: 8090
  year: 2005
  end-page: 8096
  ident: bib1010
  article-title: Apoptotic pathways are inhibited by leptin receptor activation in neutrophils
  publication-title: J. Immunol.
– volume: 11
  start-page: e0166172
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib1030
  article-title: APPL1-mediating leptin signaling contributes to proliferation and migration of cancer cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0166172
– volume: 237
  start-page: 109
  year: 2006
  ident: 10.1016/j.cytogfr.2017.11.002_bib0680
  article-title: Serum adiponectin and leptin levels in Taiwanese breast cancer patients
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2005.05.047
– volume: 45
  start-page: 536
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0895
  article-title: The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2012.12.010
– volume: 137
  start-page: 1841
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0815
  article-title: Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis
  publication-title: J. Cancer Res Clin. Oncol.
  doi: 10.1007/s00432-011-1054-5
– volume: 7
  start-page: 144
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0105
  article-title: Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer
  publication-title: Biochem. Biophys. Rep.
– volume: 27
  start-page: 581
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0820
  article-title: Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice
  publication-title: Clin. Exp. Metastasis.
  doi: 10.1007/s10585-010-9347-7
– volume: 10
  start-page: e0126686
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib1070
  article-title: Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0126686
– volume: 67
  start-page: 333
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0465
  article-title: Phosphorylated Akt expression is a prognostic marker in early-stage non-small cell lung cancer
  publication-title: J. Clin. Pathol.
  doi: 10.1136/jclinpath-2013-201870
– volume: 66
  start-page: 645
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0850
  article-title: Leptin induces a proliferative response in breast cancer cells but not in normal breast cells
  publication-title: Nutr. Cancer
  doi: 10.1080/01635581.2014.894104
– volume: 7
  start-page: e41942
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib1165
  article-title: Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0041942
– volume: 3
  start-page: 18
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0795
  article-title: Integrative analysis of pathway deregulation in obesity
  publication-title: N. P. J. Syst. Biol. Appl.
  doi: 10.1038/s41540-017-0018-z
– volume: 18
  start-page: 413
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib1060
  article-title: Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells
  publication-title: Endocr. Relat. Cancer
  doi: 10.1530/ERC-11-0075
– volume: 115
  start-page: 3457
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0470
  article-title: Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma
  publication-title: Cancer
  doi: 10.1002/cncr.24389
– volume: 21
  start-page: 165
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0070
  article-title: Leptin promotes metastasis by inducing an epithelial-mesenchymal transition in A549 lung cancer cells
  publication-title: Oncol. Res.
  doi: 10.3727/096504014X13887748696662
– volume: 64
  start-page: 3201
  year: 2007
  ident: 10.1016/j.cytogfr.2017.11.002_bib0010
  article-title: Molecular basis of invasion in breast cancer
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-007-7388-0
– volume: 2
  start-page: 165
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0190
  article-title: Local adipocytes enable estrogen-dependent breast cancer growth: role of leptin and aromatase
  publication-title: Adipocyte
  doi: 10.4161/adip.23645
– volume: 7
  start-page: 65441
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0740
  article-title: Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.11761
– volume: 8
  start-page: 6724
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0410
  article-title: Expression of CD44 in pancreatic cancer and its significance
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 170
  start-page: 198
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0870
  article-title: Leptin promotes human endometrial carcinoma cell proliferation by enhancing aromatase (P450arom) expression and estradiol formation
  publication-title: Eur. J. Obstet. Gynecol. Reprod. Biol.
  doi: 10.1016/j.ejogrb.2013.04.004
– volume: 10
  start-page: 4325
  year: 2004
  ident: 10.1016/j.cytogfr.2017.11.002_bib0690
  article-title: Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-03-0749
– volume: 45
  start-page: 189
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0050
  article-title: Obesity and breast cancer: a clinical biochemistry perspective
  publication-title: Clin. Biochem.
  doi: 10.1016/j.clinbiochem.2011.11.016
– volume: 66
  start-page: 419
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0530
  article-title: Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2012.03.002
– volume: 67
  start-page: 2497
  year: 2007
  ident: 10.1016/j.cytogfr.2017.11.002_bib1085
  article-title: Concomitant activation of the JAK/STAT, PI3 K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-3075
– volume: 285
  start-page: 36551
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0060
  article-title: Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.168542
– volume: 7
  start-page: 1699
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0725
  article-title: Regulation of epithelial-mesenchymal transition by tumor-associated macrophages in cancer
  publication-title: Am. J. Transl. Res.
– volume: 36
  start-page: 283
  year: 2006
  ident: 10.1016/j.cytogfr.2017.11.002_bib0420
  article-title: Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas
  publication-title: Ann. Clin. Lab. Sci.
– volume: 121
  start-page: 10
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0855
  article-title: Leptin influences estrogen metabolism and accelerates prostate cell proliferation
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2014.11.007
– volume: 153
  start-page: 323
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0155
  article-title: Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-015-3550-9
– volume: 16
  start-page: 201
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0340
  article-title: PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr3605
– volume: 23
  start-page: 199
  year: 2003
  ident: 10.1016/j.cytogfr.2017.11.002_bib0520
  article-title: Classification of stomach adenocarcinomas
  publication-title: Rev. Gastroenterol. Peru
– start-page: 67
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib0940
  article-title: The angiogenic switch in tumorigenesis
– volume: 75
  start-page: 917
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0310
  article-title: Activated STAT3 correlates with prognosis of non-small cell lung cancer and indicates new anticancer strategies
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-015-2710-2
– volume: 54
  start-page: 591
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0330
  article-title: The PI3 K signaling pathway mediates the biological effects of leptin
  publication-title: Arq. Bras. Endocrinol. Metabol.
  doi: 10.1590/S0004-27302010000700002
– volume: 393
  start-page: 7
  year: 2006
  ident: 10.1016/j.cytogfr.2017.11.002_bib0225
  article-title: Intracellular signalling pathways activated by leptin
  publication-title: Biochem. J.
  doi: 10.1042/BJ20051578
– volume: 12
  start-page: e0178454
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1075
  article-title: Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0178454
– volume: 176
  start-page: 1631
  year: 2006
  ident: 10.1016/j.cytogfr.2017.11.002_bib0780
  article-title: Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma
  publication-title: J. Urol.
  doi: 10.1016/j.juro.2006.06.039
– volume: 62
  start-page: 2096
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0395
  article-title: Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation
  publication-title: Glia
  doi: 10.1002/glia.22729
– volume: 179
  start-page: 147
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0405
  article-title: Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group
  publication-title: Eur. J. Obstet. Gynecol. Reprod. Biol.
  doi: 10.1016/j.ejogrb.2014.05.040
– volume: 25
  start-page: 770
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0910
  article-title: Leptin inhibits the apoptosis of endometrial carcinoma cells through activation of the nuclear factor κB-inducing kinase/IκB kinase pathway
  publication-title: Int. J. Gynecol. Cancer
  doi: 10.1097/IGC.0000000000000440
– volume: 25
  start-page: 119
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib1190
  article-title: A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice
  publication-title: J. Am. Soc Nephrol.
  doi: 10.1681/ASN.2013040432
– year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1055
  article-title: Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2
  publication-title: Cell. Oncol (Dordr.)
  doi: 10.1007/s13402-017-0342-8
– volume: 75
  start-page: 1009
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0115
  article-title: Adipocyte-derived monocyte chemotactic protein-1 (MCP-1) promotes prostate cancer progression through the induction of MMP-2 activity
  publication-title: Prostate
  doi: 10.1002/pros.22972
– volume: 29
  start-page: 641
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0685
  article-title: Obesity and breast cancer: status of leptin and adiponectin in pathological processes
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-010-9252-1
– volume: 30
  start-page: 566
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0765
  article-title: Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp023
– volume: 30
  start-page: 294
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0790
  article-title: Obesity and melanoma: could fat be fueling malignancy?
  publication-title: Pigment Cell Melanoma Res.
  doi: 10.1111/pcmr.12584
– volume: 13
  start-page: 3125
  year: 2007
  ident: 10.1016/j.cytogfr.2017.11.002_bib0810
  article-title: Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-06-2645
– volume: 6
  start-page: 2112
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0430
  article-title: Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 15
  start-page: 245
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0390
  article-title: Crosstalk between ERK, AKT, and cell survival
  publication-title: Cancer Biol. Ther.
  doi: 10.4161/cbt.27541
– volume: 43
  start-page: 394
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0880
  article-title: Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells
  publication-title: Endocrine
  doi: 10.1007/s12020-012-9788-7
– volume: 5
  start-page: 1140
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0930
  article-title: Leptin's pro-angiogenic signature in breast cancer
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers5031140
– volume: 5
  start-page: 135
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib1130
  article-title: The role of tumour-associated macrophages in bone metastasis
  publication-title: J. Bone Oncol.
  doi: 10.1016/j.jbo.2016.03.004
– volume: 21
  start-page: 792
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0030
  article-title: Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway
  publication-title: Mol. Hum. Reprod.
  doi: 10.1093/molehr/gav039
– volume: 4
  start-page: 66
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0015
  article-title: The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas
  publication-title: J. Cancer
  doi: 10.7150/jca.5112
– volume: 42
  start-page: 1113
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0840
  article-title: Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3 K/Akt signaling pathways
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2013.1789
– volume: 6
  start-page: 21782
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0025
  article-title: Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
  publication-title: Sci. Rep.
  doi: 10.1038/srep21782
– volume: 60
  start-page: 151
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1180
  article-title: Leptin resistance elicits depressive-like behaviors in rats
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2016.10.008
– volume: 57
  start-page: 454
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib1105
  article-title: Leptin induces migration and invasion of glioma cells through MMP-13 production
  publication-title: Glia
  doi: 10.1002/glia.20773
– volume: 305
  start-page: F871
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0045
  article-title: Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity
  publication-title: Am. J. Physiol. Renal Physiol.
  doi: 10.1152/ajprenal.00209.2013
– volume: 385
  start-page: 90
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0210
  article-title: Exploring the structure and conformational landscape of human leptin. A molecular dynamics approach
  publication-title: J. Theor. Biol.
  doi: 10.1016/j.jtbi.2015.08.014
– volume: 19
  start-page: 1122
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0560
  article-title: A novel leptin antagonist peptide inhibits breast cancer growth in vitro and in vivo
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/jcmm.12517
– volume: 12
  start-page: e0184451
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1160
  article-title: Stealth dissemination of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0184451
– volume: 199
  start-page: 221
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib0750
  article-title: Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression
  publication-title: J. Endocrinol.
  doi: 10.1677/JOE-08-0215
– volume: 8
  start-page: 2295
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0235
  article-title: Leptin signaling molecular actions and drug target in hepatocellular carcinoma
  publication-title: Drug Des. Devel. Ther.
– volume: 73
  start-page: 366
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0305
  article-title: JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2011.01.002
– volume: 34
  start-page: 974
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0540
  article-title: Leptin-mediated regulation of MT1-MMP localization is KIF1 B dependent and enhances gastric cancer cell invasion
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt028
– volume: 120
  start-page: 1592
  year: 2007
  ident: 10.1016/j.cytogfr.2017.11.002_bib0675
  article-title: Adipocytokines and breast cancer risk
  publication-title: Chin. Med. J. (Engl.)
  doi: 10.1097/00029330-200709020-00009
– volume: 17
  start-page: 594
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0290
  article-title: Expressions of STAT3, p-STAT3 and E-cadherin in colorectal cancer and clinical implications
  publication-title: Zhonghua Wei Chang Wai Ke Za Zhi (Chinese Journal of Gastrointestinal Surgery)
– volume: 9
  start-page: 350
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib1110
  article-title: Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2013.1786
– volume: 11
  start-page: e0160125
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0295
  article-title: The role of p-STAT3 as a prognostic and clinicopathological marker in colorectal cancer: a systematic review and meta-analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0160125
– volume: 10
  start-page: e0123217
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0110
  article-title: Adipocyte secreted factors enhance aggressiveness of prostate carcinoma cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0123217
– volume: 8
  start-page: 30576
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1120
  article-title: Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.15736
– volume: 38
  start-page: 1565
  issue: 2014
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0040
  article-title: The potential role of leptin in the vascular remodeling associated with obesity
  publication-title: Int. J. Obes. (Lond.)
  doi: 10.1038/ijo.2014.37
– volume: 29
  start-page: 2291
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0920
  article-title: Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2013.2390
– volume: 8
  start-page: 19840
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0230
  article-title: Leptin and its receptor in hematologic malignancies
  publication-title: Int. J. Clin. Exp. Med.
– volume: 8
  start-page: 431
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0285
  article-title: STAT3, p-STAT3 and HIF-1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2014.2059
– volume: 198
  start-page: 2927
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1140
  article-title: IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1600476
– volume: 68
  start-page: 9712
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib0755
  article-title: Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-1952
– volume: 33
  start-page: 11
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1025
  article-title: Underlying mechanisms for distant metastasis − Molecular biology
  publication-title: Visc. Med.
  doi: 10.1159/000454696
– volume: 37
  start-page: 91
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0580
  article-title: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3 K/Akt/mTOR signalling pathway
  publication-title: J. Biosci.
  doi: 10.1007/s12038-011-9172-4
– volume: 123
  start-page: 373
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0255
  article-title: Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β
  publication-title: APMIS
  doi: 10.1111/apm.12370
– volume: 150
  start-page: 255
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0165
  article-title: Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-015-3318-2
– volume: 18
  start-page: 3745
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0385
  article-title: PI3 K expression and PIK3CA mutations are related to colorectal cancer metastases
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v18.i28.3745
– volume: 109
  start-page: 2257
  year: 2007
  ident: 10.1016/j.cytogfr.2017.11.002_bib0460
  article-title: Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy
  publication-title: Cancer
  doi: 10.1002/cncr.22677
– volume: 22
  start-page: 50
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0345
  article-title: Analysis of PIK3CA mutations in breast cancer subtypes
  publication-title: Appl. Immunohistochem. Mol. Morphol.
  doi: 10.1097/PDM.0b013e318297afea
– volume: 110
  start-page: 1801
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0545
  article-title: Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2014.70
– volume: 2
  start-page: 295
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0925
  article-title: Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis
  publication-title: Mol. Med. Rep.
– volume: 14
  start-page: 353
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0650
  article-title: Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology in endometrial cancer
  publication-title: Cancer Biomark.
  doi: 10.3233/CBM-140415
– volume: 34
  start-page: 2041
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0020
  article-title: Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
  publication-title: Tumour Biol.
  doi: 10.1007/s13277-013-0842-8
– volume: 33
  start-page: 1872
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0260
  article-title: STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cells
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2015.3783
– volume: 8
  start-page: 75389
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0655
  article-title: The association between obesity related adipokines and risk of breast cancer: a systematic review and meta-analysis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.17853
– volume: 142
  start-page: 593
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0915
  article-title: Association between obesity and ovarian cancer
  publication-title: Rev. Med. Chil.
  doi: 10.4067/S0034-98872014000500007
– volume: 28
  start-page: 285
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib1005
  article-title: Metastasis suppressor genes
  publication-title: Histol. Histopathol.
– volume: 7
  start-page: 2346
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0135
  article-title: Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation
  publication-title: J. Cancer
  doi: 10.7150/jca.16884
– volume: 68
  start-page: 6752
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib1035
  article-title: Leptin enhances cholangiocarcinoma cell growth
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-6682
– volume: 95
  start-page: e3073
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0785
  article-title: Elevated serum leptin levels are associated with an increased risk of sentinel lymph node metastasis in cutaneous melanoma
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000003073
– volume: 37
  start-page: 289
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0005
  article-title: Adipokine leptin in obesity-related pathology of breast cancer
  publication-title: J. Biosci.
  doi: 10.1007/s12038-012-9191-9
– volume: 5
  start-page: 378
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0610
  article-title: HIF-1α pathway: role, regulation and intervention for cancer therapy, Acta Pharm
  publication-title: Sin. B
– volume: 69
  start-page: 329
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib0770
  article-title: Integrin alpha(v)beta(3)-targeted cancer therapy
  publication-title: Drug Dev. Res.
  doi: 10.1002/ddr.20265
– volume: 35
  start-page: 166
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib1100
  article-title: Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/s13046-016-0446-4
– volume: 9
  start-page: 90
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0950
  article-title: Inherent variability of cancer-specific aneuploidy generates metastases
  publication-title: Mol. Cytogenet.
  doi: 10.1186/s13039-016-0297-x
– volume: 9
  start-page: 689
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0800
  article-title: Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: role of adipokines
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2014.11.006
– volume: 49
  start-page: 197
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0565
  article-title: Leptin promotes proliferation and metastasis of human gallbladder cancer through OB-Rb leptin receptor
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2016.3530
– volume: 46
  start-page: 1535
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib1080
  article-title: Long term exposure to leptin enhances the growth of prostate cancer cells
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2015.2845
– volume: 147
  start-page: 181
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1125
  article-title: Prognostic significance of tumor-associated macrophages in ovarian cancer: a meta-analysis
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2017.07.007
– volume: 71
  start-page: 345
  year: 2005
  ident: 10.1016/j.cytogfr.2017.11.002_bib0205
  article-title: Leptin: structure, function and biology
  publication-title: Vitam. Horm.
  doi: 10.1016/S0083-6729(05)71012-8
– volume: 5
  start-page: e267
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0335
  article-title: Constitutively activated PI3 K accelerates tumor initiation and modifies histopathology of breast cancer
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2016.65
– volume: 13
  start-page: 505
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0890
  article-title: Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells
  publication-title: Cancer Biol. Med.
  doi: 10.20892/j.issn.2095-3941.2016.0079
– volume: 49
  start-page: 98
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0475
  article-title: Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma
  publication-title: Med. Mol. Morphol.
  doi: 10.1007/s00795-015-0130-3
– year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0995
  article-title: miRNAs in nutrition, obesity, and cancer: the biology of miRNAs in metabolic disorders and its relationship with cancer development
  publication-title: Mol. Nutr. Food Res.
– year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1050
  article-title: Leptin induces matrix metalloproteinase 7 expression to promote ovarian cancer cell invasion by activating ERK and JNK pathways
  publication-title: J. Cell Biochem
– volume: 469
  start-page: 35
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0360
  article-title: Mutation of genes of the PI3 K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness
  publication-title: Virchows Arch.
  doi: 10.1007/s00428-016-1938-5
– volume: 18
  start-page: 269
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0775
  article-title: Role of the adiponectin leptin ratio in prostate cancer
  publication-title: Oncol. Res.
  doi: 10.3727/096504009X12596189659367
– volume: 39
  start-page: 1588
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib1135
  article-title: Diverse macrophages polarization in tumor microenvironment
  publication-title: Arch. Pharm. Res.
  doi: 10.1007/s12272-016-0820-y
– volume: 11
  start-page: C56
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0320
  article-title: Expression of signal transducer and activator of transcription 3 in breast cancer and its clinical significance
  publication-title: J. Cancer Res. Ther.
  doi: 10.4103/0973-1482.163840
– volume: 17
  start-page: 191
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0640
  article-title: Leptin-R and its association with PI3 K/AKT signaling pathway in papillary thyroid carcinoma
  publication-title: Endocr. Relat. Cancer
  doi: 10.1677/ERC-09-0153
– volume: 31
  start-page: 32
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0120
  article-title: Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/1756-9966-31-32
– volume: 40
  start-page: 311
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0300
  article-title: A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer
  publication-title: Eur. J. Surg. Oncol.
  doi: 10.1016/j.ejso.2013.11.012
– volume: 31
  start-page: 2493
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0900
  article-title: Leptin-induced adhesion and invasion in colorectal cancer cell lines
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2014.3128
– volume: 22
  start-page: 1317
  year: 2007
  ident: 10.1016/j.cytogfr.2017.11.002_bib0525
  article-title: Correlation between expression of leptin and clinicopathological features and prognosis in patients with gastric cancer
  publication-title: J. Gastroenterol. Hepatol
  doi: 10.1111/j.1440-1746.2007.04941.x
– volume: 122
  start-page: 3078
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0695
  article-title: Overexpression of leptin and leptin receptors in breast cancer positively correlates with clinicopathological features
  publication-title: Chin. Med. J. (Engl.)
– volume: 463
  start-page: 666
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0975
  article-title: Large, rare chromosomal deletions associated with severe early-onset obesity
  publication-title: Nature
  doi: 10.1038/nature08689
– volume: 24
  start-page: 51
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0845
  article-title: Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells
  publication-title: J. Biomed. Sci.
  doi: 10.1186/s12929-017-0356-6
– volume: 117
  start-page: 1399
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0455
  article-title: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers
  publication-title: Cancer
  doi: 10.1002/cncr.25630
– volume: 5
  start-page: S3
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib1185
  article-title: The impact of comorbidity on cancer survival: a review
  publication-title: Clin. Epidemiol.
  doi: 10.2147/CLEP.S47150
– volume: 147
  start-page: 847
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0635
  article-title: Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma
  publication-title: Surgery
  doi: 10.1016/j.surg.2009.11.004
– volume: 16
  start-page: 2495
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0435
  article-title: Expression and prognostic role of MEKK3 and pERK in patients with renal clear cell carcinoma
  publication-title: Asian Pac. J Cancer Prev.
  doi: 10.7314/APJCP.2015.16.6.2495
– volume: 5
  start-page: 797
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0630
  article-title: Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2013.1125
– volume: 16
  start-page: 419
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0735
  article-title: Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2411-1
– volume: 39
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1090
  article-title: Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma
  publication-title: Tumor Biol.
  doi: 10.1177/1010428317699130
– volume: 138
  start-page: 197
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0140
  article-title: Adipocytes: impact on tumor growth and potential sites for therapeutic intervention
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2013.01.008
– volume: 10
  start-page: S2
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib0945
  article-title: Mechanisms of metastasis
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr1988
– volume: 8
  start-page: 8226
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0325
  article-title: Genomic regulation of invasion by STAT3 in triple negative breast cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14153
– volume: 32
  start-page: 550
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0175
  article-title: Paracrine and endocrine effects of adipose tissue on cancer development and progression
  publication-title: Endocr Rev.
  doi: 10.1210/er.2010-0030
– volume: 140
  start-page: 57
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib1000
  article-title: Leptin resistance in obesity: an epigenetic landscape
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2015.05.003
– volume: 26
  start-page: 197
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0715
  article-title: Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-008-9231-x
– volume: 58
  start-page: 96
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1015
  article-title: Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility
  publication-title: Croat. Med. J.
  doi: 10.3325/cmj.2017.58.96
– volume: 49
  start-page: 473
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib1150
  article-title: Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk
  publication-title: In Vitro Cell. Dev. Biol. Anim.
  doi: 10.1007/s11626-013-9629-x
– volume: 84
  start-page: 14
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0095
  article-title: Omental adipocytes enhance the invasiveness of gastric cancer cells by oleic acid-induced activation of the PI3K-Akt signaling pathway
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2016.12.002
– volume: 12
  start-page: 50
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0370
  article-title: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
  publication-title: BMC. Cancer
  doi: 10.1186/1471-2407-12-50
– volume: 16
  start-page: 1220
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0075
  article-title: Activation of IL-8 via PI3 K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells
  publication-title: Cancer Biol. Ther.
  doi: 10.1080/15384047.2015.1056409
– volume: 110
  start-page: 1525
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0555
  article-title: Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2014.45
– volume: 7
  start-page: 253
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0090
  article-title: Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment
  publication-title: World J. Stem Cells
  doi: 10.4252/wjsc.v7.i2.253
– volume: 10
  start-page: 6865
  year: 2004
  ident: 10.1016/j.cytogfr.2017.11.002_bib0445
  article-title: Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-04-0174
– volume: 12
  start-page: 5517
  year: 2006
  ident: 10.1016/j.cytogfr.2017.11.002_bib0535
  article-title: Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v12.i34.5517
– volume: 16
  start-page: 1042
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0615
  article-title: Adiposity and risk of thyroid cancer: a systematic review and meta-analysis
  publication-title: Obes. Rev.
  doi: 10.1111/obr.12321
– volume: 79
  start-page: 283
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0355
  article-title: Correlation between the incidence of PIK3CA mutations in breast cancer and histopathological characteristics of the tumor
  publication-title: Ceska Gynekol.
– volume: 23
  start-page: 603
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0970
  article-title: Transcriptional control of cancer metastasis
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2013.06.001
– volume: 69
  start-page: 601
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0980
  article-title: Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats
  publication-title: J. Physiol. Biochem.
  doi: 10.1007/s13105-012-0231-6
– volume: 1
  start-page: 245
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0195
  article-title: Leptin signaling and Alzheimer's disease
  publication-title: Am. J. Neurodegener. Dis.
– volume: 2015
  start-page: 253519
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0670
  article-title: Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal Saudi females and their possible diagnostic and predictive implications as novel biomarkers
  publication-title: Dis. Markers
  doi: 10.1155/2015/253519
– volume: 14
  start-page: 2667
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0830
  article-title: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation
  publication-title: Cell Cycle
  doi: 10.1080/15384101.2015.1041684
– volume: 72
  start-page: 18
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0835
  article-title: Leptin regulates energy metabolism in MCF-7 breast cancer cells
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2016.01.002
– volume: 960
  start-page: 571
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0660
  article-title: Obesity-associated breast cancer: analysis of risk factors
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-319-48382-5_25
– volume: 12
  start-page: e0170675
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1065
  article-title: A dangerous liaison: leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0170675
– volume: 226
  start-page: 1274
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0760
  article-title: Leptin increases motility and integrin up-regulation in human prostate cancer cells
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.22455
– volume: 68
  start-page: 471
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0380
  article-title: Clinicopathological significance of PI3 K, Akt and survivin expression in gastric cancer
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2014.03.010
– volume: 23
  start-page: 262
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0965
  article-title: Epigenetics and precision oncology
  publication-title: Cancer J.
  doi: 10.1097/PPO.0000000000000281
– volume: 6
  start-page: 7166
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0875
  article-title: Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3347
– volume: 10
  start-page: 577
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0220
  article-title: Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function
  publication-title: Curr. Protein Pept. Sci.
  doi: 10.2174/138920309789630561
– volume: 18
  start-page: 43
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib1155
  article-title: On the origin of cancer metastasis
  publication-title: Crit. Rev. Oncog.
  doi: 10.1615/CritRevOncog.v18.i1-2.40
– volume: 71
  start-page: 2455
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0180
  article-title: Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-3323
– volume: 8
  start-page: 7740
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0860
  article-title: Leptin-Notch signaling axis is involved in pancreatic cancer progression
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13946
– volume: 7
  start-page: 24495
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0150
  article-title: Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8336
– volume: 8
  start-page: 546
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0270
  article-title: Prognostic and clinical significance of STAT3 and MMP9 in patients with gastric cancer: a meta-analysis of a Chinese cohort
  publication-title: Int. J Clin. Exp. Med.
– volume: 36
  start-page: 839
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0510
  article-title: Expression of leptin and adiponectin in esophageal squamous cell carcinoma and their clinical significance
  publication-title: Zhonghua Zhong Liu Za Zhi (Chinese Journal of Oncology)
– volume: 11
  start-page: 1946
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0400
  article-title: The PI3 K/AKT/mTOR interactive pathway
  publication-title: Mol. Biosyst.
  doi: 10.1039/C5MB00101C
– volume: 106
  start-page: 232
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0865
  article-title: Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells
  publication-title: Food Chem Toxicol.
  doi: 10.1016/j.fct.2017.05.058
– volume: 18
  start-page: 2519
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0665
  article-title: Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancer
  publication-title: J. Cell. Mol. Med.
  doi: 10.1111/jcmm.12413
– volume: 223
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0215
  article-title: 20 years of leptin: insights into signaling assemblies of the leptin receptor
  publication-title: J. Endocrinol.
  doi: 10.1530/JOE-14-0264
– volume: 188
  start-page: 560
  year: 2004
  ident: 10.1016/j.cytogfr.2017.11.002_bib1040
  article-title: Leptin induces cell migration and the expression of growth factors in human prostate cancer cells
  publication-title: Am. J. Surg.
  doi: 10.1016/j.amjsurg.2004.07.031
– volume: 208
  start-page: 398
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0485
  article-title: pERK activation in esophageal carcinomas: clinicopathological associations
  publication-title: Pathol. Res. Pract.
  doi: 10.1016/j.prp.2012.05.009
– volume: 29
  start-page: 1272
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib1095
  article-title: The effect of leptin and its mechanisms on the migration and invasion of human breast cancer MCF-7 cells
  publication-title: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (Chinese Journal of Cellular and Molecular Immunology)
– volume: 11
  start-page: 620
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0350
  article-title: PIK3CA gene amplification and PI3 K p110α protein expression in breast carcinoma
  publication-title: Int. J. Med. Sci.
  doi: 10.7150/ijms.8251
– volume: 38
  start-page: 326
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0200
  article-title: Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish
  publication-title: Peptides
  doi: 10.1016/j.peptides.2012.10.002
– volume: 17
  start-page: 849
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0745
  article-title: Breast cancer cell colonization of the human bone marrow adipose tissue niche
  publication-title: Neoplasia
  doi: 10.1016/j.neo.2015.11.005
– volume: 68
  start-page: 1383
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0985
  article-title: DNA methylation in obesity
  publication-title: Postepy Hig Med. Dosw. (Online)
  doi: 10.5604/17322693.1130084
– volume: 172
  start-page: 2974
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0825
  article-title: Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-(B pathway activation in human myometrial cells
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.13100
– volume: 60
  start-page: 241
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0585
  article-title: Expression and biological significance of leptin, leptin receptor, VEGF, and CD34 in colorectal carcinoma
  publication-title: Cell Biochem. Biophys.
  doi: 10.1007/s12013-010-9145-5
– volume: 32
  start-page: 104
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1045
  article-title: RhoA/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2017.01.020
– volume: 136
  start-page: 258
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib1145
  article-title: High-fat diet-induced obesity increases lymphangiogenesis and lymph node metastasis in the B16F10 melanoma allograft model: roles of adipocytes and M2-macrophages
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.28983
– volume: 217
  start-page: 283
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib1175
  article-title: A superactive leptin antagonist alters metabolism and locomotion in high-leptin mice
  publication-title: J. Endocrinol.
  doi: 10.1530/JOE-13-0033
– volume: 39
  start-page: 1085
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0245
  article-title: Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment
  publication-title: Arch. Pharm. Res.
  doi: 10.1007/s12272-016-0795-8
– volume: 16
  start-page: 426
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0700
  article-title: Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway
  publication-title: Breast Cancer Res.
  doi: 10.1186/s13058-014-0426-6
– volume: 15
  start-page: 133
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0955
  article-title: The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome
  publication-title: BMC. Med.
  doi: 10.1186/s12916-017-0900-y
– volume: 32
  start-page: 9870
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib1020
  article-title: TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0353-12.2012
– volume: 10
  start-page: e0130839
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0515
  article-title: Implication of leptin-signaling proteins and epstein-barr virus in gastric carcinomas
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0130839
– volume: 27
  start-page: 1023
  year: 2009
  ident: 10.1016/j.cytogfr.2017.11.002_bib0550
  article-title: Cell adhesion molecules: role and clinical significance in cancer
  publication-title: Cancer Invest.
  doi: 10.3109/07357900902769749
– volume: 354
  start-page: 172
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0605
  article-title: Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2014.08.001
– volume: 1845
  start-page: 136
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0240
  article-title: Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
  publication-title: Biochim. Biophys. Acta
– volume: 7
  start-page: 5940
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0450
  article-title: REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 174
  start-page: 8090
  year: 2005
  ident: 10.1016/j.cytogfr.2017.11.002_bib1010
  article-title: Apoptotic pathways are inhibited by leptin receptor activation in neutrophils
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.12.8090
– volume: 83
  start-page: 261
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0625
  article-title: Expression of leptin and its receptor in thyroid carcinoma: distinctive prognostic significance in different subtypes
  publication-title: Clin. Endocrinol. (Oxf.)
  doi: 10.1111/cen.12598
– volume: 142
  start-page: 649
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0275
  article-title: The prognostic value of pSTAT3 in gastric cancer: a meta-analysis
  publication-title: J. Cancer Res Clin. Oncol.
  doi: 10.1007/s00432-015-2023-1
– volume: 7
  start-page: 86075
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0905
  article-title: Adipocytes secreted leptin is a pro-tumor factor for survival of multiple myeloma under chemotherapy
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13342
– volume: 1831
  start-page: 1533
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0085
  article-title: Adipose tissue and adipocytes support tumorigenesis and metastasis
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbalip.2013.02.010
– volume: 6
  start-page: 21100
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0080
  article-title: Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4228
– volume: 287
  start-page: 8598
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0065
  article-title: Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.322800
– volume: 32
  start-page: 319
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0495
  article-title: Determination of risk for Barrett's esophagus and esophageal adenocarcinoma
  publication-title: Curr. Opin. Gastroenterol.
  doi: 10.1097/MOG.0000000000000274
– volume: 17
  start-page: e11
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0125
  article-title: Invasive breast cancer preferably and predominantly occurs at the interface between fibroglandular and adipose tissue
  publication-title: Clin. Breast Cancer
  doi: 10.1016/j.clbc.2016.07.009
– volume: 14
  start-page: 157
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0575
  article-title: Metabolic syndrome and leptin are associated with adverse pathological features in male colorectal cancer patients
  publication-title: Colorectal Dis.
  doi: 10.1111/j.1463-1318.2011.02562.x
– year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib1170
– volume: 17
  start-page: 112
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0055
  article-title: Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers
  publication-title: Breast Cancer Res.
  doi: 10.1186/s13058-015-0622-z
– volume: 43
  start-page: 857
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0805
  article-title: Type 2 diabetes mellitus and risk of malignant melanoma: a systematic review and meta-analysis of cohort studies
  publication-title: Iran. J. Public Health
– volume: 16
  start-page: 400
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0365
  article-title: Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review
  publication-title: BMC. Cancer
  doi: 10.1186/s12885-016-2422-y
– volume: 6
  start-page: 756
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0280
  article-title: STAT3 regulation the expression of VEGF-D in HGC-27 gastric cancer cell
  publication-title: Am. J. Transl. Res.
– volume: 26
  start-page: 1265
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0645
  article-title: Leptin enhances migration of human papillary thyroid cancer cells through the PI3 K/AKT and MEK/ERK signaling pathways
  publication-title: Oncol. Rep.
– volume: 36
  start-page: 358
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0145
  article-title: Interaction between breast cancer cells and adipose tissue cells derived from fat grafting
  publication-title: Aesthet. Surg. J.
  doi: 10.1093/asj/sjv194
– volume: 17
  start-page: 79
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0035
  article-title: Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects
  publication-title: Horm. Mol. Biol. Clin. Investig.
  doi: 10.1515/hmbci-2013-0069
– volume: 151
  start-page: 453
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0990
  article-title: Body mass index associated with genome-wide methylation in breast tissue
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-015-3401-8
– volume: 16
  start-page: 4986
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0375
  article-title: Up-regulation of PIK3CA promotes metastasis in gastric carcinoma
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v16.i39.4986
– volume: 54
  start-page: 37
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0440
  article-title: Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations
  publication-title: Hum. Pathol.
  doi: 10.1016/j.humpath.2016.03.001
– volume: 17
  start-page: 165
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0490
  article-title: High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer
  publication-title: Ann. Diagn. Pathol.
  doi: 10.1016/j.anndiagpath.2012.09.004
– volume: 50
  start-page: 753
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0250
  article-title: Regulation of EMT by STAT3 in gastrointestinal cancer (review)
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2017.3846
– volume: 48
  start-page: 2479
  year: 2016
  ident: 10.1016/j.cytogfr.2017.11.002_bib0720
  article-title: Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2016.3483
– volume: 36
  start-page: 6813
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0885
  article-title: ObRb downregulation increases breast cancer cell sensitivity to tamoxifen
  publication-title: Tumour Biol.
  doi: 10.1007/s13277-015-3375-5
– volume: 127
  start-page: 407
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0425
  article-title: Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-010-1012-y
– volume: 38
  start-page: 900
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0960
  article-title: Intratumor heterogeneity predicts metastasis of triple-negative breast cancer
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgx071
– volume: 36
  start-page: 26
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0130
  article-title: Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/s13046-017-0494-4
– volume: 24
  start-page: 272
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0500
  article-title: Adenocarcinoma versus squamous cell carcinoma: analysis of 306 patients in university hospital
  publication-title: Arq. Bras. Cir Dig.
  doi: 10.1590/S0102-67202011000400005
– volume: 29
  start-page: 1596
  year: 2008
  ident: 10.1016/j.cytogfr.2017.11.002_bib0935
  article-title: Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma
  publication-title: Peptides
  doi: 10.1016/j.peptides.2008.05.011
– volume: 6
  start-page: 16120
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0600
  article-title: Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3878
– volume: 6
  start-page: e21467
  year: 2011
  ident: 10.1016/j.cytogfr.2017.11.002_bib0710
  article-title: Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0021467
– volume: 12
  start-page: 35
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0730
  article-title: Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-12-35
– volume: 10
  start-page: e0119348
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0170
  article-title: Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0119348
– volume: 6
  start-page: 18674
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0415
  article-title: High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4367
– volume: 24
  start-page: 190
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0620
  article-title: Obesity and thyroid cancer: a clinical update
  publication-title: Thyroid
  doi: 10.1089/thy.2013.0232
– volume: 591
  start-page: 3022
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib1115
  article-title: Cellular metabolism of tumor-associated macrophages − functional impact and consequences
  publication-title: FEBS. Lett.
  doi: 10.1002/1873-3468.12771
– volume: 61
  start-page: 619
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0570
  article-title: Serum adipokines and their receptors in endometrial and colon cancer patients: relationship with tumor invasion and metastasis
  publication-title: Vopr. Onkol.
– volume: 6
  start-page: 11203
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0505
  article-title: Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3587
– volume: 11
  start-page: 79
  year: 2012
  ident: 10.1016/j.cytogfr.2017.11.002_bib0480
  article-title: Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-11-79
– volume: 17
  start-page: 179
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0590
  article-title: Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways
  publication-title: Endocr. Relat. Cancer
  doi: 10.1677/ERC-09-0225
– volume: 6
  start-page: 39
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0185
  article-title: Adipocyte activation of cancer stem cell signaling in breast cancer
  publication-title: World J. Biol Chem.
  doi: 10.4331/wjbc.v6.i2.39
– volume: 32
  start-page: 2760
  year: 2014
  ident: 10.1016/j.cytogfr.2017.11.002_bib0315
  article-title: Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2014.3536
– volume: 177
  start-page: 3133
  year: 2010
  ident: 10.1016/j.cytogfr.2017.11.002_bib0705
  article-title: Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2010.100595
– volume: 8
  start-page: 7710
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0265
  article-title: STAT3 overexpression promotes metastasis in intrahepatic cholangiocarcinoma and correlates negatively with surgical outcome
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13846
– volume: 8
  start-page: e2593
  year: 2017
  ident: 10.1016/j.cytogfr.2017.11.002_bib0100
  article-title: Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2017.21
– volume: 46
  start-page: 306
  year: 2013
  ident: 10.1016/j.cytogfr.2017.11.002_bib0595
  article-title: Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer
  publication-title: Braz. J. Med. Biol. Res.
  doi: 10.1590/1414-431X20122559
– volume: 33
  start-page: 2689
  year: 2015
  ident: 10.1016/j.cytogfr.2017.11.002_bib0160
  article-title: Adipocyte hypoxia promotes epithelial-mesenchymal transition-related gene expression and estrogen receptor-negative phenotype in breast cancer cells
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2015.3880
– reference: 24569475 - Br J Cancer. 2014 Mar 18;110(6):1525-34
– reference: 26017929 - Cell Cycle. 2015;14(16):2667-76
– reference: 23354006 - Int J Oncol. 2013 Mar;42(3):1113-9
– reference: 20945385 - J Cell Physiol. 2011 May;226(5):1274-82
– reference: 20954287 - World J Gastroenterol. 2010 Oct 21;16(39):4986-91
– reference: 27388016 - BMC Cancer. 2016 Jul 07;16:400
– reference: 25846733 - Tumour Biol. 2015 Sep;36(9):6813-21
– reference: 26147886 - PLoS One. 2015 Jul 06;10(7):e0130839
– reference: 25704884 - Oncotarget. 2015 Mar 30;6(9):7166-81
– reference: 27568102 - Clin Breast Cancer. 2017 Feb;17 (1):e11-e18
– reference: 22292935 - BMC Cancer. 2012 Feb 01;12:50
– reference: 25060812 - Glia. 2014 Dec;62(12):2096-109
– reference: 24321071 - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Dec;29(12):1272-6
– reference: 27820851 - PLoS One. 2016 Nov 7;11(11):e0166172
– reference: 25499031 - Mol Oncol. 2015 Mar;9(3):689-703
– reference: 28785563 - Visc Med. 2017 Mar;33(1):11-20
– reference: 24424114 - Cancer Biol Ther. 2014 Mar 1;15(3):245-6
– reference: 25924008 - Mol Biosyst. 2015 Jul;11(7):1946-54
– reference: 25158596 - Clin Endocrinol (Oxf). 2015 Aug;83(2):261-7
– reference: 19952122 - Endocr Relat Cancer. 2010 Feb 18;17(1):179-89
– reference: 25192370 - Breast Cancer Res. 2014 Jan 23;16(1):201
– reference: 25721149 - J Cell Mol Med. 2015 May;19(5):1122-32
– reference: 23681802 - Tumour Biol. 2013 Aug;34(4):2041-51
– reference: 28911002 - Carcinogenesis. 2017 Sep 1;38(9):900-909
– reference: 26899873 - Sci Rep. 2016 Feb 22;6:21782
– reference: 18715880 - J Endocrinol. 2008 Nov;199(2):221-33
– reference: 21161731 - Cell Biochem Biophys. 2011 Jul;60(3):241-4
– reference: 28770546 - Cell Oncol (Dordr). 2017 Dec;40(6):537-547
– reference: 25909054 - Iran J Public Health. 2014 Jul;43(7):857-66
– reference: 21056997 - Am J Pathol. 2010 Dec;177(6):3133-44
– reference: 27387344 - BMC Cancer. 2016 Jul 07;16:419
– reference: 22851869 - World J Gastroenterol. 2012 Jul 28;18(28):3745-51
– reference: 23991363 - Adipocyte. 2013 Jul 1;2(3):165-9
– reference: 25928422 - PLoS One. 2015 Apr 30;10(4):e0123217
– reference: 22273460 - BMC Cancer. 2012 Jan 24;12:35
– reference: 19526593 - Cancer. 2009 Aug 1;115(15):3457-67
– reference: 25919692 - PLoS One. 2015 Apr 28;10(4):e0126686
– reference: 25398149 - Ceska Gynekol. 2014 Aug;79(4):283-8
– reference: 25811593 - Int J Gynecol Cancer. 2015 Jun;25(5):770-8
– reference: 19909018 - Cancer Invest. 2009 Dec;27(10):1023-37
– reference: 25063754 - J Endocrinol. 2014 Oct;223(1):T9-23
– reference: 21555376 - Endocr Relat Cancer. 2011 Jul 01;18(4):413-28
– reference: 26286584 - Breast Cancer Res. 2015 Aug 19;17:112
– reference: 28771701 - FEBS Lett. 2017 Oct;591(19):3022-3041
– reference: 23932299 - Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):198-201
– reference: 23386906 - J Cancer. 2013;4(1):66-83
– reference: 26342543 - J Theor Biol. 2015 Nov 21;385:90-101
– reference: 15944317 - J Immunol. 2005 Jun 15;174(12):8090-6
– reference: 25953686 - Breast Cancer Res Treat. 2015 Jun;151(2):453-63
– reference: 22270359 - J Biol Chem. 2012 Mar 9;287(11):8598-612
– reference: 25482303 - Breast Cancer Res. 2014 Oct 25;16(5):426
– reference: 22815502 - J Neurosci. 2012 Jul 18;32(29):9870-7
– reference: 23334856 - J Physiol Biochem. 2013 Sep;69(3):601-11
– reference: 26009703 - World J Biol Chem. 2015 May 26;6(2):39-47
– reference: 23183114 - Ann Diagn Pathol. 2013 Apr;17(2):165-71
– reference: 16019138 - Cancer Lett. 2006 Jun 8;237(1):109-14
– reference: 17363567 - Cancer Res. 2007 Mar 15;67(6):2497-507
– reference: 25427016 - Rev Med Chil. 2014 May;142(5):593-8
– reference: 23708919 - In Vitro Cell Dev Biol Anim. 2013 Jun;49(6):473-8
– reference: 21642230 - Endocr Rev. 2011 Aug;32(4):550-70
– reference: 25171477 - Cancer Biomark. 2014;14(5):353-9
– reference: 25484575 - Drug Des Devel Ther. 2014 Nov 14;8:2295-302
– reference: 20225764 - Oncol Res. 2009;18(5-6):269-77
– reference: 19112600 - Clin Exp Metastasis. 2009;26(3):197-204
– reference: 28427165 - Oncotarget. 2017 May 2;8(18):30576-30586
– reference: 25948792 - Oncotarget. 2015 Jun 30;6(18):16120-34
– reference: 25747684 - PLoS One. 2015 Mar 06;10(3):e0119348
– reference: 16952705 - J Urol. 2006 Oct;176(4 Pt 1):1631-5
– reference: 20628538 - Drug Dev Res. 2008;69(6):329-339
– reference: 24512731 - Oncol Res. 2013;21(3):165-71
– reference: 28154783 - Cancer Biol Med. 2016 Dec;13(4):505-513
– reference: 23353703 - Pharmacol Ther. 2013 May;138(2):197-210
– reference: 20821253 - Cancer Metastasis Rev. 2010 Dec;29(4):641-53
– reference: 24782652 - Int J Med Sci. 2014 Apr 22;11(6):620-5
– reference: 15546570 - Am J Surg. 2004 Nov;188(5):560-5
– reference: 25130171 - Cancer Lett. 2014 Nov 1;354(1):172-80
– reference: 24700392 - Oncol Rep. 2014 Jun;31(6):2493-8
– reference: 22658382 - Pathol Res Pract. 2012 Jul 15;208(7):398-404
– reference: 23482705 - J Endocrinol. 2013 Apr 29;217(3):283-90
– reference: 27562774 - Arch Pharm Res. 2016 Nov;39(11):1588-1596
– reference: 25846563 - APMIS. 2015 May;123(5):373-82
– reference: 26153131 - Mol Hum Reprod. 2015 Oct;21(10):792-802
– reference: 28585217 - Adv Exp Med Biol. 2017;960:571-606
– reference: 22848668 - PLoS One. 2012;7(7):e41942
– reference: 24332948 - Eur J Surg Oncol. 2014 Mar;40(3):311-7
– reference: 19966786 - Nature. 2010 Feb 4;463(7281):666-70
– reference: 26121010 - Cancer Biol Ther. 2015;16(8):1220-30
– reference: 24213635 - Mol Med Rep. 2014 Jan;9(1):350-4
– reference: 18573568 - Peptides. 2008 Sep;29(9):1596-602
– reference: 25735252 - Cancer Chemother Pharmacol. 2015 May;75(5):917-22
– reference: 26705127 - Med Mol Morphol. 2016 Jun;49(2):98-109
– reference: 24583853 - Int J Obes (Lond). 2014 Dec;38(12):1565-72
– reference: 28030809 - Oncotarget. 2017 Jan 31;8(5):8226-8238
– reference: 28594107 - Mol Nutr Food Res. 2017 Jun 8;:null
– reference: 25337238 - Int J Clin Exp Pathol. 2014 Aug 15;7(9):5940-9
– reference: 27956048 - Int J Biochem Cell Biol. 2017 Mar;84:14-21
– reference: 24471188 - Appl Immunohistochem Mol Morphol. 2014 Jan;22(1):50-6
– reference: 26571833 - Vopr Onkol. 2015;61(4):619-23
– reference: 23500888 - Biochim Biophys Acta. 2013 Oct;1831(10):1533-41
– reference: 21333372 - Lung Cancer. 2011 Sep;73(3):366-74
– reference: 21689278 - Colorectal Dis. 2012 Feb;14 (2):157-65
– reference: 27504822 - PLoS One. 2016 Aug 09;11(8):e0160125
– reference: 25917126 - Prostate. 2015 Jul 1;75(10):1009-19
– reference: 29088874 - Oncotarget. 2017 May 13;8(43):75389-75399
– reference: 23588620 - Oncol Rep. 2013 Jun;29(6):2291-6
– reference: 27027351 - Oncotarget. 2016 Apr 26;7(17 ):24495-509
– reference: 28032598 - Oncotarget. 2017 Jan 31;8(5):7710-7721
– reference: 24953370 - Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jun;17(6):594-7
– reference: 28957348 - PLoS One. 2017 Sep 28;12 (9):e0184451
– reference: 26579469 - Acta Pharm Sin B. 2015 Sep;5(5):378-89
– reference: 27588409 - Oncotarget. 2016 Oct 4;7(40):65441-65453
– reference: 25372732 - Horm Mol Biol Clin Investig. 2014 Feb;17(2):79-87
– reference: 19751193 - Curr Protein Pept Sci. 2009 Dec;10(6):577-84
– reference: 27743935 - Brain Behav Immun. 2017 Feb;60:151-160
– reference: 28098855 - Int J Oncol. 2017 Mar;50(3):753-767
– reference: 26233579 - J Cancer Res Clin Oncol. 2016 Mar;142(3):649-57
– reference: 24959290 - Oncol Lett. 2014 Jul;8(1):431-437
– reference: 17440983 - Cancer. 2007 Jun 1;109 (11):2257-67
– reference: 27761375 - J Bone Oncol. 2016 Apr 08;5(3):135-138
– reference: 24738610 - Nutr Cancer. 2014;66(4):645-55
– reference: 18701500 - Cancer Res. 2008 Aug 15;68(16):6752-61
– reference: 26261555 - Int J Clin Exp Pathol. 2015 Jun 01;8(6):6724-31
– reference: 23354307 - Carcinogenesis. 2013 May;34(5):974-83
– reference: 27211817 - Int J Oncol. 2016 Jul;49(1):197-206
– reference: 28409493 - Croat Med J. 2017 Apr 14;58(2):96-104
– reference: 20137505 - Chin Med J (Engl). 2009 Dec 20;122(24):3078-81
– reference: 24844408 - Int J Cancer. 2015 Jan 15;136(2):258-70
– reference: 25721605 - Breast Cancer Res Treat. 2015 Apr;150(2):255-63
– reference: 26323925 - J Cancer Res Ther. 2015 Aug;11 Suppl 1:C56-8
– reference: 28222242 - Pigment Cell Melanoma Res. 2017 May;30(3):294-306
– reference: 25823469 - Oncol Rep. 2015 Jun;33(6):2689-94
– reference: 19168585 - Carcinogenesis. 2009 Apr;30(4):566-74
– reference: 23237552 - Crit Rev Oncog. 2013;18(1-2):43-73
– reference: 28926426 - Cancer J. 2017 Sep/Oct;23 (5):262-269
– reference: 25620481 - Zhonghua Zhong Liu Za Zhi. 2014 Nov;36(11):839-43
– reference: 22469146 - J Exp Clin Cancer Res. 2012 Apr 02;31:32
– reference: 24965996 - Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:147-52
– reference: 22968658 - Endocrine. 2013 Apr;43(2):394-403
– reference: 21085763 - Arq Bras Endocrinol Metabol. 2010 Oct;54(7):591-602
– reference: 16951269 - Ann Clin Lab Sci. 2006 Summer;36(3):283-93
– reference: 28571770 - Food Chem Toxicol. 2017 Aug;106(Pt A):232-241
– reference: 21750869 - Oncol Rep. 2011 Nov;26(5):1265-71
– reference: 27036313 - Hum Pathol. 2016 Aug;54:37-46
– reference: 20617378 - Breast Cancer Res Treat. 2011 Jun;127(2):407-16
– reference: 28018487 - Mol Cytogenet. 2016 Dec 16;9:90
– reference: 26124180 - Oncotarget. 2015 Jul 30;6(21):18674-82
– reference: 17545514 - Clin Cancer Res. 2007 Jun 1;13(11):3125-32
– reference: 16112274 - Vitam Horm. 2005;71:345-72
– reference: 19047149 - Cancer Res. 2008 Dec 1;68(23):9712-22
– reference: 28104444 - Cell Signal. 2017 Apr;32:104-114
– reference: 20045163 - Surgery. 2010 Jun;147(6):847-53
– reference: 23348381 - Histol Histopathol. 2013 Mar;28(3):285-92
– reference: 25310198 - Oncol Rep. 2014 Dec;32(6):2760-8
– reference: 28151470 - Cell Death Dis. 2017 Feb 2;8(2):e2593
– reference: 28716075 - BMC Med. 2017 Jul 18;15(1):133
– reference: 23879222 - Thyroid. 2014 Feb;24(2):190-9
– reference: 27769315 - J Exp Clin Cancer Res. 2016 Oct 21;35(1):166
– reference: 23085324 - Peptides. 2012 Dec;38(2):326-36
– reference: 28173833 - J Exp Clin Cancer Res. 2017 Feb 7;36(1):26
– reference: 21475828 - Mol Med Rep. 2009 Mar-Apr;2(2):295-9
– reference: 24133589 - Int J Clin Exp Pathol. 2013 Sep 15;6(10 ):2112-20
– reference: 26692918 - Am J Transl Res. 2015 Oct 15;7(10):1699-711
– reference: 25653024 - Oncol Rep. 2015 Apr;33(4):1872-82
– reference: 27082857 - Int J Oncol. 2016 Jun;48(6):2479-87
– reference: 25338520 - J Cell Mol Med. 2014 Dec;18(12):2519-29
– reference: 27863383 - Oncotarget. 2016 Dec 27;7(52):86075-86086
– reference: 28750624 - J Biomed Sci. 2017 Jul 27;24(1):51
– reference: 24227920 - Clin Epidemiol. 2013 Nov 01;5(Suppl 1):3-29
– reference: 22178111 - Clin Biochem. 2012 Feb;45(3):189-97
– reference: 25998029 - Life Sci. 2015 Nov 1;140:57-63
– reference: 25653112 - Br J Pharmacol. 2015 Jun;172(12):2974-90
– reference: 26772821 - Int J Biochem Cell Biol. 2016 Mar;72 :18-26
– reference: 26884894 - Int J Clin Exp Med. 2015 Nov 15;8(11):19840-9
– reference: 28885729 - J Cell Biochem. 2017 Sep 8;:null
– reference: 28249041 - PLoS One. 2017 Mar 1;12 (3):e0170675
– reference: 23838335 - Trends Cell Biol. 2013 Dec;23(12):603-11
– reference: 14532921 - Rev Gastroenterol Peru. 2003 Jul-Sep;23(3):199-212
– reference: 27999190 - Oncotarget. 2017 Jan 31;8(5):7740-7752
– reference: 23262295 - Int J Biochem Cell Biol. 2013 Mar;45(3):536-45
– reference: 28698008 - Gynecol Oncol. 2017 Oct;147(1):181-187
– reference: 27059323 - Virchows Arch. 2016 Jul;469(1):35-43
– reference: 26986135 - Medicine (Baltimore). 2016 Mar;95(11):e3073
– reference: 28459203 - Tumour Biol. 2017 May;39(5):1010428317699130
– reference: 26285644 - Breast Cancer Res Treat. 2015 Sep;153(2):323-35
– reference: 25838618 - Dis Markers. 2015;2015:253519
– reference: 27617308 - Biochem Biophys Rep. 2016 Sep;7:144-149
– reference: 17006991 - World J Gastroenterol. 2006 Sep 14;12(34):5517-22
– reference: 22357207 - J Biosci. 2012 Mar;37(1):91-101
– reference: 28542577 - PLoS One. 2017 May 25;12 (5):e0178454
– reference: 25433128 - Life Sci. 2015 Jan 15;121:10-5
– reference: 22883999 - Biomed Pharmacother. 2012 Sep;66(6):419-24
– reference: 24388873 - Biochim Biophys Acta. 2014 Apr;1845(2):136-54
– reference: 26499941 - Aesthet Surg J. 2016 Mar;36(3):358-63
– reference: 27797363 - Oncogenesis. 2016 Oct 31;5(10 ):e267
– reference: 23425972 - Oncol Lett. 2013 Mar;5(3):797-800
– reference: 26365757 - Obes Rev. 2015 Dec;16(12):1042-54
– reference: 22581334 - J Biosci. 2012 Jun;37(2):289-94
– reference: 25815113 - World J Stem Cells. 2015 Mar 26;7(2):253-65
– reference: 25625287 - Int J Oncol. 2015 Apr;46(4):1535-42
– reference: 28193830 - J Immunol. 2017 Apr 1;198(7):2927-2934
– reference: 23083134 - Mol Cancer. 2012 Oct 21;11:79
– reference: 25857300 - Oncotarget. 2015 May 10;6(13):11203-15
– reference: 28685099 - NPJ Syst Biol Appl. 2017 Jun 30;3:18
– reference: 15501963 - Clin Cancer Res. 2004 Oct 15;10(20):6865-71
– reference: 23558862 - Braz J Med Biol Res. 2013 Mar;46(3):306-10
– reference: 24115476 - J Am Soc Nephrol. 2014 Jan;25(1):119-28
– reference: 16336196 - Biochem J. 2006 Jan 1;393(Pt 1):7-20
– reference: 20843817 - J Biol Chem. 2010 Nov 19;285(47):36551-60
– reference: 24548863 - Br J Cancer. 2014 Apr 2;110(7):1801-10
– reference: 15240518 - Clin Cancer Res. 2004 Jul 1;10(13):4325-31
– reference: 27515050 - Arch Pharm Res. 2016 Aug;39(8):1085-99
– reference: 21425139 - Cancer. 2011 Apr 1;117(7):1399-408
– reference: 27276368 - Curr Opin Gastroenterol. 2016 Jul;32(4):319-24
– reference: 20008098 - Endocr Relat Cancer. 2010 Feb 18;17(1):191-202
– reference: 17559372 - J Gastroenterol Hepatol. 2007 Aug;22(8):1317-21
– reference: 21927908 - J Cancer Res Clin Oncol. 2011 Dec;137(12):1841-8
– reference: 23383396 - Am J Neurodegener Dis. 2012;1(3):245-65
– reference: 25531701 - Postepy Hig Med Dosw (Online). 2014 Nov 27;68:1383-91
– reference: 18814267 - Glia. 2009 Mar;57(4):454-64
– reference: 24726064 - Biomed Pharmacother. 2014 May;68(4):471-5
– reference: 21731759 - PLoS One. 2011;6(6):e21467
– reference: 20697780 - Clin Exp Metastasis. 2010 Dec;27(8):581-90
– reference: 25824786 - Asian Pac J Cancer Prev. 2015;16(6):2495-9
– reference: 21459803 - Cancer Res. 2011 Apr 1;71(7):2455-65
– reference: 25628786 - Am J Transl Res. 2014 Nov 22;6(6):756-67
– reference: 17908478 - Chin Med J (Engl). 2007 Sep 20;120(18):1592-6
– reference: 24265323 - J Clin Pathol. 2014 Apr;67(4):333-40
– reference: 25785029 - Int J Clin Exp Med. 2015 Jan 15;8(1):546-57
– reference: 26053184 - Oncotarget. 2015 Aug 28;6(25):21100-19
– reference: 27994674 - J Cancer. 2016 Nov 26;7(15):2346-2359
– reference: 24202338 - Cancers (Basel). 2013 Sep 06;5(3):1140-62
– reference: 19091006 - Breast Cancer Res. 2008;10 Suppl 1:S2
– reference: 17957337 - Cell Mol Life Sci. 2007 Dec;64(24):3201-18
– reference: 26696367 - Neoplasia. 2015 Dec;17 (12 ):849-861
– reference: 23863467 - Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F871-80
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Snippet Red: Tumor-promoting effect. Blue: Dual role (tumor–suppressor or −promoting effect depending on the situation). CAFs: Cancer-associated fibroblasts, CTGF:...
The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in obesity compared to its functions in the normal healthy state. In obese...
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SubjectTerms Invasive cancer
Leptin
Metastasis
Obesity
Prognosis
Title The potential role of leptin in tumor invasion and metastasis
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https://dx.doi.org/10.1016/j.cytogfr.2017.11.002
https://www.ncbi.nlm.nih.gov/pubmed/29158066
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