Systematic comparison of family history and polygenic risk across 24 common diseases

Family history is the standard indirect measure of inherited susceptibility in clinical care, whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more directly capturing genetic risk in many diseases. Few studies have systematically compared how these overlap and compl...

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Vydané v:	American journal of human genetics Ročník 109; číslo 12; s. 2152
Hlavní autori:	Mars, Nina, Lindbohm, Joni V, Della Briotta Parolo, Pietro, Widén, Elisabeth, Kaprio, Jaakko, Palotie, Aarno, Ripatti, Samuli
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.12.2022
Predmet:	Adult Diabetes Mellitus, Type 2 - genetics Genetic Predisposition to Disease Genome-Wide Association Study Humans Medical History Taking Multifactorial Inheritance - genetics Risk Factors risk assessment polygenic risk score family history
ISSN:	1537-6605, 1537-6605
On-line prístup:	Zistit podrobnosti o prístupe
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