Systematic comparison of family history and polygenic risk across 24 common diseases

Family history is the standard indirect measure of inherited susceptibility in clinical care, whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more directly capturing genetic risk in many diseases. Few studies have systematically compared how these overlap and compl...

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Veröffentlicht in:	American journal of human genetics Jg. 109; H. 12; S. 2152
Hauptverfasser:	Mars, Nina, Lindbohm, Joni V, Della Briotta Parolo, Pietro, Widén, Elisabeth, Kaprio, Jaakko, Palotie, Aarno, Ripatti, Samuli
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2022
Schlagworte:	Adult Diabetes Mellitus, Type 2 - genetics Genetic Predisposition to Disease Genome-Wide Association Study Humans Medical History Taking Multifactorial Inheritance - genetics Risk Factors risk assessment polygenic risk score family history
ISSN:	1537-6605, 1537-6605
Online-Zugang:	Weitere Angaben
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