Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis

ABSTRACT BACKGROUND/PURPOSE To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). METHODS Brain MRI fluid‐attenuated inversion‐recovery (FLAIR) sequences were performed in 32 multiple sclerosis (MS) patients. Expanded Disability Status Sca...

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Veröffentlicht in:Journal of neuroimaging Jg. 21; H. 2; S. e50 - e56
Hauptverfasser: Stankiewicz, James M., Glanz, Bonnie I., Healy, Brian C., Arora, Ashish, Neema, Mohit, Benedict, Ralph H.B., Guss, Zachary D., Tauhid, Shahamat, Buckle, Guy J., Houtchens, Maria K., Khoury, Samia J., Weiner, Howard L., Guttmann, Charles R.G., Bakshi, Rohit
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Malden, USA Blackwell Publishing Inc 01.04.2011
Schlagworte:
1.5T
Adult
Brain - physiopathology
Case-Control Studies
Cognition Disorders - physiopathology
cognitive testing
Disability Evaluation
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging - methods
Male
Middle Aged
MRI
multiple sclerosis
Multiple Sclerosis - physiopathology
Neuropsychological Tests
Sensitivity and Specificity
Statistics, Nonparametric
Surveys and Questionnaires
ISSN:1051-2284, 1552-6569, 1552-6569
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Zusammenfassung:ABSTRACT BACKGROUND/PURPOSE To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). METHODS Brain MRI fluid‐attenuated inversion‐recovery (FLAIR) sequences were performed in 32 multiple sclerosis (MS) patients. Expanded Disability Status Scale (EDSS) score (mean ± standard deviation) was 2 ± 2.0 (range 0‐8), disease duration 9.3 ± 8.0 (range .8‐29) years. RESULTS FLAIR lesion volume (FLLV) at 3T was higher than at 1.5T (P= .01). Correlation between 1.5T FLLV and EDSS score was poor, while 3T FLLV correlated moderately and significantly (rs= .39, P= .03). When controlling for age and depression, correlations between FLLV and cognitive measures were significant at 1.5T for the Judgment of Line Orientation test (JLO) (rs=−.44, P= .05), the Symbol Digit Modalities Test (SDMT) (rs=−.49, P= .02), and the California Verbal Learning Test Delayed Free Recall (CVLT DR) (rs=−.44, P= .04). Correlations at 3T were also significant for these tests, but of greater magnitude: JLO (rs=−.70, P= .0005), SDMT (rs=−.73, P= .0001), CVLT DR (rs=−.061, P= .003). Additional significant correlations obtained only at 3T included the 2 second‐paced auditory serial addition test (rs=−.55, P= .01), the Brief Visuospatial Memory Test‐Delayed Free Recall (rs=−.56, P= .007), and the California Verbal Learning Test Total Recall (rs=−.42, P= .05). CONCLUSION MRI at 3T may boost sensitivity and improve validity in MS brain lesion assessment.
Bibliographie:istex:B44A04B405EE7546B4EEFE653008797508E6886F
ArticleID:JON449
ark:/67375/WNG-JKQZTDZ5-8
Correction added after online publication 10‐November‐2009: Second sentence in the Abstract has been reworded
Funding sources
This work was supported by research grants to Dr. Bakshi from the National Institutes of Health (1R01NS055083‐01) and National Multiple Sclerosis Society (RG3705A1; RG3798A2). Authors have nothing to disclose.
J Neuroimaging 2011;21:e50‐e56.
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ISSN:1051-2284
1552-6569
1552-6569
DOI:10.1111/j.1552-6569.2009.00449.x