Expression of immune response biomarkers (PD-L1, p16, CD3+ and CD8+ TILs) in recurrent head and neck squamous cell carcinoma within previously irradiated areas

The immune landscape of head and neck squamous cell carcinoma in pretreated areas remains poorly documented. We aimed to assess the tumor microenvironment for biomarkers of antitumor immune responses in tumors in previously irradiated areas compared with de novo tumors. This retrospective monocentri...

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Bibliographic Details
Published in:	Oncology reports Vol. 45; no. 3; pp. 1273 - 1283
Main Authors:	Pflumio, Carole, Thomas, Jacques, Salleron, Julia, Faivre, Jean-Christophe, Borel, Christian, Dolivet, Gilles, Sastre-Garau, Xavier, Geoffrois, Lionnel
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01.03.2021 Spandidos Publications Spandidos Publications UK Ltd
Subjects:	Adaptive immunology Biochemistry, Molecular Biology Biological markers Biomarkers Cancer Clinical trials Comparative analysis Genomics Head & neck cancer head and neck cancer human papillomavirus Immune response Immunohistochemistry Immunology Immunotherapy irradiated area Life Sciences Medical prognosis Metastasis Papillomavirus infections Patients PD-L1 programmed death-ligand 1 Radiation therapy Radiotherapy Regions Squamous cell carcinoma Surgery TIL tumor microenvironment tumor-infiltrating lymphocytes Tumors head and neck cancer tumor‑infiltrating lymphocytes TIL human papillomavirus radiotherapy PD-L1 programmed death‑ligand 1 tumor microenvironment squamous cell carcinoma irradiated area
ISSN:	1021-335X, 1791-2431, 1791-2431
Online Access:	Get full text
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