Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical p...

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Bibliographic Details

Published in:	Chemical science (Cambridge) Vol. 11; no. 5; pp. 1368 - 1374
Main Authors:	Subiros-Funosas, Ramon, Ho, Vivian Cheuk Lam, Barth, Nicole D, Mendive-Tapia, Lorena, Pappalardo, Morena, Barril, Xavier, Ma, Ruoyu, Zhang, Cheng-Bin, Qian, Bin-Zhi, Sintes, Miquel, Ghashghaei, Ouldouz, Lavilla, Rodolfo, Vendrell, Marc
Format:	Journal Article
Language:	English
Published:	CAMBRIDGE Royal Soc Chemistry 2020 Royal Society of Chemistry The Royal Society of Chemistry
Subjects:	Chemistry Chemistry, Multidisciplinary Keratin Organic chemistry Physical Sciences Science & Technology BREAST-CANCER TRYPTOPHAN AMINO-ACID FLUORESCENT-PROBE PEPTIDE RAY CRYSTAL-STRUCTURE
ISSN:	2041-6520, 2041-6539
Online Access:	Get full text
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