Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation includ...

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Published in:International journal of impotence research Vol. 20; no. 1; pp. 68 - 72
Main Authors: Mazo, E B, Gamidov, S I, Mamedov, M N, Iremashvili, V V
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.01.2008
Nature Publishing
Nature Publishing Group
Subjects:
Adult
Aged
Aged, 80 and over
Angiotensin converting enzyme
Complications and side effects
Enzymes
Erectile dysfunction
Erectile Dysfunction - enzymology
Erectile Dysfunction - genetics
Genetic aspects
Genetic polymorphisms
Genotype
Genotype & phenotype
Health aspects
Humans
Impotence
INDEL Mutation
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - enzymology
Metabolic Syndrome - genetics
Metabolic syndrome X
Middle Aged
original-article
Peptidyl-Dipeptidase A - genetics
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Reproductive Medicine
Risk Factors
rology
Russia
Urology
Russia
metabolic syndrome
angiotensin-converting enzyme insertion/deletion polymorphism
endothelial dysfunction
erectile dysfunction
ISSN:0955-9930, 1476-5489, 1476-5489
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Abstract This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group ( P <0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes ( P <0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age ( P <0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro- and macrovascular diseases.
AbstractList This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group (P<0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes (P<0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age (P<0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro- and macrovascular diseases.
This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group ( P <0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes ( P <0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age ( P <0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro- and macrovascular diseases.
This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group (P<0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes (P<0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age (P<0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro- and macrovascular diseases.This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group (P<0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes (P<0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age (P<0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro- and macrovascular diseases.
Audience Academic
Author Iremashvili, V V
Mamedov, M N
Gamidov, S I
Mazo, E B
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Cites_doi 10.1038/sj.jhh.1000638
10.1161/01.CIR.91.2.270
10.1038/sj.ijir.3900437
10.1111/j.1365-2362.2007.01755.x
10.1038/sj.ijir.3900261
10.1172/JCI114844
10.1161/01.CIR.90.5.2199
10.1016/S0090-4295(99)00099-0
10.3317/jraas.2006.003
10.1056/NEJM199503163321103
10.2337/diacare.28.5.1201
10.1002/j.1939-4640.2004.tb02847.x
10.1001/jama.285.19.2486
10.1016/j.amjhyper.2006.01.004
10.1042/cs0930391
10.1016/S0090-4295(01)01312-7
10.1161/01.CIR.91.8.2120
10.1253/circj.67.572
10.1097/00000441-200105000-00006
10.1016/S0090-4295(03)00137-7
10.1161/01.CIR.0000088846.10655.E0
10.1016/S0022-5347(01)64901-2
10.2337/diab.37.12.1595
10.1016/S0140-6736(05)66378-7
10.1681/ASN.V7102025
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Keywords metabolic syndrome
angiotensin-converting enzyme insertion/deletion polymorphism
endothelial dysfunction
erectile dysfunction
Language English
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References Park, Kim, Kim, Koh, Park (CR19) 1999; 11
Ferrario (CR24) 2006; 7
Kifor, Williams, Vickers, Sullivan, Jodbert, Dluhy (CR26) 1997; 157
Reaven (CR2) 1988; 37
(CR21) 2001; 285
Matsusaka, Hymes, Ichikawa (CR8) 1996; 7
Cambien, Alhenc-Gelas, Herbeth, Andre, Rakotovao, Gonzales (CR11) 1988; 43
Cappelleri, Rosen, Smith, Mishra, Osterloh (CR22) 1999; 54
Nicholls, Richards, Agarwal (CR7) 1998; 12
Barbalic, Skaric-Juric, Cambien, Barbaux, Poirier, Turek (CR17) 2006; 19
Becker, Uckert, Stief, Scheller, Knapp, Hartmann (CR9) 2001; 58
Vanhoutte (CR23) 2003; 67
Wassink, Olijhoek, Visseren (CR3) 2007; 37
Comiter, Sullivan, Yalla, Kifor (CR10) 1997; 9
Llisterri, Lozano Vidal, Aznar Vicente, Argaya Roca, Pol Bravo, Sanchez Zamorano (CR27) 2001; 321
Mattu, Needham, Galton, Frangos, Clark, Caulfield (CR14) 1995; 91
Esposito, Giugliano, Martedi, Feola, Marfella, D'Armento (CR5) 2005; 28
Eckel, Grundy, Zimmet (CR1) 2005; 365
Butler, Morris, Struthers (CR18) 1997; 93
Reilly, Rader (CR4) 2003; 108
Rosas-Vargas, Coral-Vazquez, Tapia, Borja, Salas, Salamanca (CR20) 2004; 25
Rigat, Hubert, Alhenc-Gelas, Cambien, Corvol, Soubrier (CR12) 1990; 86
Nakai, Itoh, Miura, Hotta, Musha, Itoh (CR15) 1994; 90
Becker, Uckert, Stief, Scheller, Knapp, Hartmann (CR25) 2001; 13
Lindpainter, Pfeffer, Kreutz, Stampfer, Grodstein, LaMotte (CR13) 1995; 332
Eisenhardt, Sperling, Hauck, Porst, Stief, Rübben (CR28) 2003; 62
Gndüz, Gümüs, Sekuri (CR6) 2004; 6
Ludwig, Cornell, Anderson, Marshall, Lalonel, Ward (CR16) 1995; 95
RH Eckel (BF3901598_CR1) 2005; 365
B Rigat (BF3901598_CR12) 1990; 86
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (BF3901598_CR21) 2001; 285
MI Gndüz (BF3901598_CR6) 2004; 6
M Barbalic (BF3901598_CR17) 2006; 19
CM Ferrario (BF3901598_CR24) 2006; 7
JC Cappelleri (BF3901598_CR22) 1999; 54
MP Reilly (BF3901598_CR4) 2003; 108
RK Mattu (BF3901598_CR14) 1995; 91
K Lindpainter (BF3901598_CR13) 1995; 332
I Kifor (BF3901598_CR26) 1997; 157
MG Nicholls (BF3901598_CR7) 1998; 12
PM Vanhoutte (BF3901598_CR23) 2003; 67
AJ Becker (BF3901598_CR25) 2001; 13
GM Reaven (BF3901598_CR2) 1988; 37
AJ Becker (BF3901598_CR9) 2001; 58
K Esposito (BF3901598_CR5) 2005; 28
T Matsusaka (BF3901598_CR8) 1996; 7
CV Comiter (BF3901598_CR10) 1997; 9
A Eisenhardt (BF3901598_CR28) 2003; 62
K Nakai (BF3901598_CR15) 1994; 90
H Rosas-Vargas (BF3901598_CR20) 2004; 25
JL Llisterri (BF3901598_CR27) 2001; 321
AM Wassink (BF3901598_CR3) 2007; 37
F Cambien (BF3901598_CR11) 1988; 43
JK Park (BF3901598_CR19) 1999; 11
E Ludwig (BF3901598_CR16) 1995; 95
R Butler (BF3901598_CR18) 1997; 93
References_xml – volume: 12
  start-page: 295
  year: 1998
  end-page: 299
  ident: CR7
  article-title: The importance of the renin-angiotensin system in cardiovascular disease
  publication-title: J Hum Hypertens
  doi: 10.1038/sj.jhh.1000638
– volume: 91
  start-page: 270
  year: 1995
  end-page: 274
  ident: CR14
  article-title: A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study
  publication-title: Circulation
  doi: 10.1161/01.CIR.91.2.270
– volume: 11
  start-page: 273
  year: 1999
  end-page: 276
  ident: CR19
  article-title: Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction
  publication-title: Int J Impot Res
  doi: 10.1038/sj.ijir.3900437
– volume: 37
  start-page: 8
  year: 2007
  end-page: 17
  ident: CR3
  article-title: The metabolic syndrome: metabolic changes with vascular consequences
  publication-title: Eur J Clin Invest
  doi: 10.1111/j.1365-2362.2007.01755.x
– volume: 43
  start-page: 774
  year: 1988
  end-page: 780
  ident: CR11
  article-title: Familial resemblance of plasma angiotensin-converting enzyme level: The Nancy study
  publication-title: Am J Hum Genet
– volume: 13
  start-page: S16
  issue: suppl 1
  year: 2001
  ident: CR25
  article-title: Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence
  publication-title: Int J Impot Res
– volume: 6
  start-page: 355
  year: 2004
  end-page: 358
  ident: CR6
  article-title: Relationship between metabolic syndrome and erectile dysfunction
  publication-title: Asian J Androl
– volume: 9
  start-page: 135
  year: 1997
  end-page: 140
  ident: CR10
  article-title: Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: studies in canines
  publication-title: Int J Impot Res
  doi: 10.1038/sj.ijir.3900261
– volume: 86
  start-page: 1343
  year: 1990
  end-page: 1346
  ident: CR12
  article-title: An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels
  publication-title: J Clin Invest
  doi: 10.1172/JCI114844
– volume: 90
  start-page: 2199
  year: 1994
  end-page: 2202
  ident: CR15
  article-title: Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese
  publication-title: Circulation
  doi: 10.1161/01.CIR.90.5.2199
– volume: 54
  start-page: 346
  year: 1999
  end-page: 351
  ident: CR22
  article-title: Diagnostic evaluation of the erectile function domain of the international index of erectile function
  publication-title: Urology
  doi: 10.1016/S0090-4295(99)00099-0
– volume: 7
  start-page: 3
  year: 2006
  end-page: 14
  ident: CR24
  article-title: Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research
  publication-title: J Renin Angiotensin Aldosterone Syst
  doi: 10.3317/jraas.2006.003
– volume: 332
  start-page: 706
  year: 1995
  end-page: 711
  ident: CR13
  article-title: A prospective evaluation of an angiotensin-converting enzyme gene polymorphism and the risk of ischaemic heart disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199503163321103
– volume: 28
  start-page: 1201
  year: 2005
  end-page: 1203
  ident: CR5
  article-title: High proportions of erectile dysfunction in men with the metabolic syndrome
  publication-title: Diabetes Care
  doi: 10.2337/diacare.28.5.1201
– volume: 25
  start-page: 728
  year: 2004
  end-page: 732
  ident: CR20
  article-title: Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population
  publication-title: J Androl
  doi: 10.1002/j.1939-4640.2004.tb02847.x
– volume: 285
  start-page: 2486
  year: 2001
  end-page: 2497
  ident: CR21
  article-title: Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III)
  publication-title: JAMA
  doi: 10.1001/jama.285.19.2486
– volume: 19
  start-page: 837
  year: 2006
  end-page: 842
  ident: CR17
  article-title: Gene polymorphisms of the renin-angiotensin system and early development of hypertension
  publication-title: Am J Hypertens
  doi: 10.1016/j.amjhyper.2006.01.004
– volume: 7
  start-page: 2025
  year: 1996
  end-page: 2043
  ident: CR8
  article-title: Angiotensin in progressive renal disease: theory and practice
  publication-title: J Am Soc Nephrol
– volume: 93
  start-page: 391
  year: 1997
  end-page: 400
  ident: CR18
  article-title: Angiotensin-converting enzyme gene polymorphism and cardiovascular disease
  publication-title: Clin Sci
  doi: 10.1042/cs0930391
– volume: 58
  start-page: 805
  year: 2001
  end-page: 810
  ident: CR9
  article-title: Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction
  publication-title: Urology
  doi: 10.1016/S0090-4295(01)01312-7
– volume: 95
  start-page: 2120
  year: 1995
  end-page: 2124
  ident: CR16
  article-title: Angiotensin-converting enzyme gene deletion polymorphism is associated with myocardial infarction but not with development of coronary stenosis
  publication-title: Circulation
  doi: 10.1161/01.CIR.91.8.2120
– volume: 67
  start-page: 572
  year: 2003
  end-page: 575
  ident: CR23
  article-title: Endothelial control of vasomotor function
  publication-title: Circ J
  doi: 10.1253/circj.67.572
– volume: 321
  start-page: 336
  year: 2001
  end-page: 341
  ident: CR27
  article-title: Sexual dysfunction in hypertensive patients treated with losartan
  publication-title: Am J Med Sci
  doi: 10.1097/00000441-200105000-00006
– volume: 62
  start-page: 152
  year: 2003
  end-page: 157
  ident: CR28
  article-title: ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction
  publication-title: Urology
  doi: 10.1016/S0090-4295(03)00137-7
– volume: 108
  start-page: 1546
  year: 2003
  end-page: 1551
  ident: CR4
  article-title: The metabolic syndrome: more than the sum of its parts?
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000088846.10655.E0
– volume: 157
  start-page: 1920
  year: 1997
  end-page: 1925
  ident: CR26
  article-title: Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum
  publication-title: J Urol
  doi: 10.1016/S0022-5347(01)64901-2
– volume: 37
  start-page: 1595
  year: 1988
  end-page: 1607
  ident: CR2
  article-title: Role of insulin resistance in human disease
  publication-title: Diabetes
  doi: 10.2337/diab.37.12.1595
– volume: 365
  start-page: 1415
  year: 2005
  end-page: 1428
  ident: CR1
  article-title: The metabolic syndrome
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)66378-7
– volume: 11
  start-page: 273
  year: 1999
  ident: BF3901598_CR19
  publication-title: Int J Impot Res
  doi: 10.1038/sj.ijir.3900437
– volume: 43
  start-page: 774
  year: 1988
  ident: BF3901598_CR11
  publication-title: Am J Hum Genet
– volume: 321
  start-page: 336
  year: 2001
  ident: BF3901598_CR27
  publication-title: Am J Med Sci
  doi: 10.1097/00000441-200105000-00006
– volume: 67
  start-page: 572
  year: 2003
  ident: BF3901598_CR23
  publication-title: Circ J
  doi: 10.1253/circj.67.572
– volume: 54
  start-page: 346
  year: 1999
  ident: BF3901598_CR22
  publication-title: Urology
  doi: 10.1016/S0090-4295(99)00099-0
– volume: 157
  start-page: 1920
  year: 1997
  ident: BF3901598_CR26
  publication-title: J Urol
  doi: 10.1016/S0022-5347(01)64901-2
– volume: 86
  start-page: 1343
  year: 1990
  ident: BF3901598_CR12
  publication-title: J Clin Invest
  doi: 10.1172/JCI114844
– volume: 91
  start-page: 270
  year: 1995
  ident: BF3901598_CR14
  publication-title: Circulation
  doi: 10.1161/01.CIR.91.2.270
– volume: 62
  start-page: 152
  year: 2003
  ident: BF3901598_CR28
  publication-title: Urology
  doi: 10.1016/S0090-4295(03)00137-7
– volume: 37
  start-page: 8
  year: 2007
  ident: BF3901598_CR3
  publication-title: Eur J Clin Invest
  doi: 10.1111/j.1365-2362.2007.01755.x
– volume: 93
  start-page: 391
  year: 1997
  ident: BF3901598_CR18
  publication-title: Clin Sci
  doi: 10.1042/cs0930391
– volume: 9
  start-page: 135
  year: 1997
  ident: BF3901598_CR10
  publication-title: Int J Impot Res
  doi: 10.1038/sj.ijir.3900261
– volume: 332
  start-page: 706
  year: 1995
  ident: BF3901598_CR13
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199503163321103
– volume: 6
  start-page: 355
  year: 2004
  ident: BF3901598_CR6
  publication-title: Asian J Androl
– volume: 58
  start-page: 805
  year: 2001
  ident: BF3901598_CR9
  publication-title: Urology
  doi: 10.1016/S0090-4295(01)01312-7
– volume: 285
  start-page: 2486
  year: 2001
  ident: BF3901598_CR21
  publication-title: JAMA
  doi: 10.1001/jama.285.19.2486
– volume: 7
  start-page: 3
  year: 2006
  ident: BF3901598_CR24
  publication-title: J Renin Angiotensin Aldosterone Syst
  doi: 10.3317/jraas.2006.003
– volume: 7
  start-page: 2025
  year: 1996
  ident: BF3901598_CR8
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.V7102025
– volume: 13
  start-page: S16
  issue: suppl 1
  year: 2001
  ident: BF3901598_CR25
  publication-title: Int J Impot Res
– volume: 95
  start-page: 2120
  year: 1995
  ident: BF3901598_CR16
  publication-title: Circulation
  doi: 10.1161/01.CIR.91.8.2120
– volume: 108
  start-page: 1546
  year: 2003
  ident: BF3901598_CR4
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000088846.10655.E0
– volume: 12
  start-page: 295
  year: 1998
  ident: BF3901598_CR7
  publication-title: J Hum Hypertens
  doi: 10.1038/sj.jhh.1000638
– volume: 28
  start-page: 1201
  year: 2005
  ident: BF3901598_CR5
  publication-title: Diabetes Care
  doi: 10.2337/diacare.28.5.1201
– volume: 19
  start-page: 837
  year: 2006
  ident: BF3901598_CR17
  publication-title: Am J Hypertens
  doi: 10.1016/j.amjhyper.2006.01.004
– volume: 90
  start-page: 2199
  year: 1994
  ident: BF3901598_CR15
  publication-title: Circulation
  doi: 10.1161/01.CIR.90.5.2199
– volume: 365
  start-page: 1415
  year: 2005
  ident: BF3901598_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)66378-7
– volume: 25
  start-page: 728
  year: 2004
  ident: BF3901598_CR20
  publication-title: J Androl
  doi: 10.1002/j.1939-4640.2004.tb02847.x
– volume: 37
  start-page: 1595
  year: 1988
  ident: BF3901598_CR2
  publication-title: Diabetes
  doi: 10.2337/diab.37.12.1595
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Snippet This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile...
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StartPage 68
SubjectTerms Adult
Aged
Aged, 80 and over
Angiotensin converting enzyme
Complications and side effects
Enzymes
Erectile dysfunction
Erectile Dysfunction - enzymology
Erectile Dysfunction - genetics
Genetic aspects
Genetic polymorphisms
Genotype
Genotype & phenotype
Health aspects
Humans
Impotence
INDEL Mutation
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - enzymology
Metabolic Syndrome - genetics
Metabolic syndrome X
Middle Aged
original-article
Peptidyl-Dipeptidase A - genetics
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Reproductive Medicine
Risk Factors
rology
Russia
Urology
Title Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome
URI https://link.springer.com/article/10.1038/sj.ijir.3901598
https://www.ncbi.nlm.nih.gov/pubmed/17673929
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https://www.proquest.com/docview/2645332955
https://www.proquest.com/docview/70197298
Volume 20
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