Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation includ...

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Veröffentlicht in:International journal of impotence research Jg. 20; H. 1; S. 68 - 72
Hauptverfasser: Mazo, E B, Gamidov, S I, Mamedov, M N, Iremashvili, V V
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.01.2008
Nature Publishing
Nature Publishing Group
Schlagworte:
Adult
Aged
Aged, 80 and over
Angiotensin converting enzyme
Complications and side effects
Enzymes
Erectile dysfunction
Erectile Dysfunction - enzymology
Erectile Dysfunction - genetics
Genetic aspects
Genetic polymorphisms
Genotype
Genotype & phenotype
Health aspects
Humans
Impotence
INDEL Mutation
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - enzymology
Metabolic Syndrome - genetics
Metabolic syndrome X
Middle Aged
original-article
Peptidyl-Dipeptidase A - genetics
Polymerase Chain Reaction
Polymorphism
Polymorphism, Genetic
Reproductive Medicine
Risk Factors
rology
Russia
Urology
Russia
metabolic syndrome
angiotensin-converting enzyme insertion/deletion polymorphism
endothelial dysfunction
erectile dysfunction
ISSN:0955-9930, 1476-5489, 1476-5489
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Zusammenfassung:This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group ( P <0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes ( P <0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age ( P <0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro- and macrovascular diseases.
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ISSN:0955-9930
1476-5489
1476-5489
DOI:10.1038/sj.ijir.3901598