Worldwide emergence of multiple clades of enterovirus 68

Human enterovirus 68 (EV-D68) is a historically rarely reported virus linked with respiratory disease. In the past 3 years, a large increase in respiratory disease associated with EV-D68 has been reported, with documented outbreaks in North America, Europe and Asia. In several outbreaks, genetic dif...

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Vydané v:Journal of general virology Ročník 93; číslo Pt 9; s. 1952
Hlavní autori: Tokarz, Rafal, Firth, Cadhla, Madhi, Shabir A, Howie, Stephen R C, Wu, Winfred, Sall, Amadou Alpha, Haq, Saddef, Briese, Thomas, Lipkin, W Ian
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.09.2012
Predmet:
Adolescent
Adult
Asia - epidemiology
Base Sequence
Child
Child, Preschool
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - virology
Enterovirus D, Human - classification
Enterovirus D, Human - genetics
Enterovirus D, Human - isolation & purification
Enterovirus Infections - epidemiology
Enterovirus Infections - virology
Europe - epidemiology
Female
Global Health
Humans
Infant
Male
Molecular Sequence Data
North America - epidemiology
Phylogeny
Young Adult
Asia
North America
Europe
ISSN:1465-2099, 1465-2099
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Popis
Shrnutí:Human enterovirus 68 (EV-D68) is a historically rarely reported virus linked with respiratory disease. In the past 3 years, a large increase in respiratory disease associated with EV-D68 has been reported, with documented outbreaks in North America, Europe and Asia. In several outbreaks, genetic differences were identified among the circulating strains, indicating the presence of multiple clades. In this report, we analyse archived and novel EV-D68 strains from Africa and the USA, obtained from patients with respiratory illness. Phylogenetic analysis of all EV-D68 sequences indicates that, over the past two decades, multiple clades of the virus have emerged and spread rapidly worldwide. All clades appear to be currently circulating and contributing to respiratory disease.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1465-2099
1465-2099
DOI:10.1099/vir.0.043935-0