Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series

Abstract Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7% of all head-neck keratinocyte carcinomas. Although...

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Vydáno v:Case reports in dermatology Ročník 16; číslo 1; s. 1 - 7
Hlavní autoři: Bocchino, Enrico, Cappilli, Simone, Palmisano, Gerardo, Paradisi, Andrea, Piccerillo, Alfredo, Di Stefani, Alessandro, Peris, Ketty
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel, Switzerland S. Karger AG 01.01.2024
Karger Publishers
Témata:
Alopecia
Baldness
basosquamous carcinoma
Biopsy
Cancer
Case reports
Case Series
clinical dermatology
Females
Magnetic resonance imaging
Multidisciplinary teams
Muscle pain
Nausea
Patients
Radiation therapy
sonic hedgehog pathway inhibitors
sonidegib
Surgery
vismodegib
Clinical dermatology
Sonic hedgehog pathway inhibitors
Vismodegib
Basosquamous carcinoma
Sonidegib
ISSN:1662-6567, 1662-6567
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Shrnutí:Abstract Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7% of all head-neck keratinocyte carcinomas. Although systemic therapy with hedgehog inhibitors (HHIs) represents the first-line medical treatment in advanced BCC, to date, no standard therapy for advanced basosquamous carcinoma has been established. Herein, we reported a case series of patients affected by locally advanced basosquamous carcinomas, who were treated with HHIs. Case Presentation: Data of 5 patients receiving HHIs for locally advanced basosquamous carcinomas were retrieved (2 women and 3 males, age range: 63–89 years, average age of 77 years). Skin lesions were located on the head-neck area; in particular, 4 tumors involved orbital and periorbital area and 1 tumor developed in the retro-auricular region. A clinical response was obtained in 3 out of 5 patients (2 partial responses and 1 complete response), while disease progression was observed in the remaining 2 patients. Hence, therapy was interrupted, switching to surgery or immunotherapy. Conclusion: Increasing evidence suggests considering HHIs for large skin tumors developing in functionally and cosmetically sensitive areas, in patients with multiple comorbidities, although their use for basosquamous carcinoma require more exploration, large cohort populations, and long follow-up assessment.
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ISSN:1662-6567
1662-6567
DOI:10.1159/000535506