Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies

Key Points The emergence of cancer immunotherapy has revolutionized cancer treatment but is associated with serious immune-related adverse effects (IRAEs) Cytotoxic T-lymphocyte antigen 4 (CTLA4)-targeted immunotherapy is associated with increased susceptibility to hypophysitis and primary thyroid d...

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Bibliographic Details
Published in:	Nature reviews. Endocrinology Vol. 13; no. 4; pp. 195 - 207
Main Authors:	Byun, David J., Wolchok, Jedd D., Rosenberg, Lynne M., Girotra, Monica
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.04.2017 Nature Publishing Group
Subjects:	631/154/51/1568 692/163/2743/1279 692/163/2743/1841 692/163/2743/2742/1738 692/308/409 692/699/67/1059/2325 692/700/565/1436 Animals Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Cancer therapies Cancer treatment Complications and side effects CTLA-4 Antigen - biosynthesis Endocrine diseases Endocrine System Diseases - chemically induced Endocrine System Diseases - immunology Endocrine System Diseases - metabolism Endocrinology Enzyme inhibitors Humans Hyperthyroidism Hypothyroidism Immune system Immunotherapy Immunotherapy - adverse effects Ipilimumab Kinases Ligands Lymphocytes Medicine & Public Health Metastasis Monoclonal antibodies Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Patients Programmed Cell Death 1 Receptor - biosynthesis Proteins review-article Risk factors T cell receptors United States > US
ISSN:	1759-5029, 1759-5037, 1759-5037
Online Access:	Get full text
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