Dopamine-dependent long-term depression at subthalamo-nigral synapses is lost in experimental parkinsonism

Impairments of synaptic plasticity are a hallmark of several neurological disorders, including Parkinson's disease (PD) which results from the progressive loss of dopaminergic neurons of the substantia nigra pars compacta leading to abnormal activity within the basal ganglia (BG) network and pa...

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Veröffentlicht in:	The Journal of neuroscience Jg. 33; H. 36; S. 14331
Hauptverfasser:	Dupuis, Julien Pierre, Feyder, Michael, Miguelez, Cristina, Garcia, Liliana, Morin, Stéphanie, Choquet, Daniel, Hosy, Eric, Bezard, Erwan, Fisone, Gilberto, Bioulac, Bernard H, Baufreton, Jérôme
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.09.2013
Schlagworte:	Animals Dopamine - metabolism Dopaminergic Neurons - physiology Endocytosis Long-Term Synaptic Depression Male Parkinsonian Disorders - chemically induced Parkinsonian Disorders - physiopathology Rats Rats, Sprague-Dawley Receptors, AMPA - metabolism Receptors, Dopamine D5 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Substantia Nigra - physiopathology Synapses - physiology Thalamus - physiopathology
ISSN:	1529-2401, 1529-2401
Online-Zugang:	Weitere Angaben
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