Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae

The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and th...

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Vydáno v:International Journal of Molecular Sciences Ročník 25; číslo 7; s. 3669
Hlavní autoři: Lee, Ayoung, Kim, Seung Young, Kang, Seyoung, Kang, Seong Hee, Kim, Dong Woo, Choe, Jung Wan, Hyun, Jong Jin, Jung, Sung Woo, Jung, Young Kul, Koo, Ja Seol, Yim, Hyung Joon, Kim, Suhyun
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.04.2024
Témata:
Animals
Aquaporins
Bifidobacterium longum
Constipation
Constipation - etiology
Constipation - therapy
Corticosteroids
Gut-brain axis
Hormones
Hydrocortisone
Hypothalamus
Inflammation
Irritable bowel syndrome
Larva
Light
Microbiota
Microbiota (Symbiotic organisms)
Motility
Neurophysiology
Physiology
Probiotics
Probiotics - pharmacology
Probiotics - therapeutic use
Scientific equipment and supplies industry
Stress
Stress (Psychology)
Vasoactive intestinal peptides
Zebrafish
United States
South Korea
constipation
stress
zebrafish
B. longum
light
ISSN:1422-0067, 1661-6596, 1422-0067
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Shrnutí:The pathophysiology of functional bowel disorders is complex, involving disruptions in gut motility, visceral hypersensitivity, gut–brain–microbiota interactions, and psychosocial factors. Light pollution, as an environmental stressor, has been associated with disruptions in circadian rhythms and the aggravation of stress-related conditions. In this study, we investigated the effects of environmental stress, particularly continuous light exposure, on intestinal motility and inflammation using zebrafish larvae as a model system. We also evaluated the efficacy of probiotics, specifically Bifidobacterium longum (B. longum), at alleviating stress-induced constipation. Our results showed that continuous light exposure in zebrafish larvae increased the cortisol levels and reduced the intestinal motility, establishing a stress-induced-constipation model. We observed increased inflammatory markers and decreased intestinal neural activity in response to stress. Furthermore, the expressions of aquaporins and vasoactive intestinal peptide, crucial for regulating water transport and intestinal motility, were altered in the light-induced constipation model. Administration of probiotics, specifically B. longum, ameliorated the stress-induced constipation by reducing the cortisol levels, modulating the intestinal inflammation, and restoring the intestinal motility and neural activity. These findings highlight the potential of probiotics to modulate the gut–brain axis and alleviate stress-induced constipation. Therefore, this study provides a valuable understanding of the complex interplay among environmental stressors, gut function, and potential therapeutic strategies.
Bibliografie:ObjectType-Article-1
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25073669