The Role of Long Noncoding RNAs (lncRNAs) in Esophageal Cancer Therapy Resistance and Metastasis

Esophageal cancer (EC) is one of the most aggressive gastrointestinal cancers. Despite improvements in therapies, the survival rate of patients with EC remains low. Metastasis accounts for up to 90% of cancer-related deaths, and resistance to anti-neoplastic therapeutics is also a main cause of poor...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Biomedicines Ročník 12; číslo 3; s. 660
Hlavní autori: Weng, Zong-Ping, Hsu, Shen-Kai, Wang, Hui-Min David, Chen, Kuo-Jen, Lee, Po-Yen, Chiu, Chien-Chih, Cheng, Kai-Chun
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.03.2024
MDPI
Predmet:
Antimitotic agents
Antineoplastic agents
Breast cancer
Cancer
Cancer therapies
Care and treatment
Cell adhesion & migration
Cell cycle
Development and progression
Disease
Drug resistance
Epigenetic inheritance
Epigenetics
Esophageal cancer
esophageal cancer (EC)
Gastric cancer
Gene expression
Gene regulation
Genetic transcription
Genomes
Health aspects
Kinases
long noncoding RNAs (lncRNAs)
Lung cancer
Medical prognosis
Metastases
Metastasis
Non-coding RNA
Nucleotides
Post-transcription
Proteins
Review
RNA
RNA polymerase
Roles
Survival
Therapeutic targets
Tumorigenesis
Tumors
Taiwan
long noncoding RNAs (lncRNAs)
drug resistance
metastasis
esophageal cancer (EC)
ISSN:2227-9059, 2227-9059
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Esophageal cancer (EC) is one of the most aggressive gastrointestinal cancers. Despite improvements in therapies, the survival rate of patients with EC remains low. Metastasis accounts for up to 90% of cancer-related deaths, and resistance to anti-neoplastic therapeutics is also a main cause of poor survival. Thus, metastasis and drug resistance are undoubtedly the two main challenges in cancer treatment. Among the different categories of noncoding RNAs, lncRNAs have historically drawn less attention. However, lncRNAs have gradually become a research hotspot, and increasing research has demonstrated that lncRNAs participate in the tumorigenesis of multiple types of cancer, including EC. Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides in length that play important roles in epigenetics, transcription regulation, and posttranscriptional processing. In this review, we elucidated the role of lncRNAs in the metastasis and drug resistance of EC and discussed their potential clinical applications and related limitations. With a better understanding of the underlying mechanisms of lncRNAs, we can identify therapeutic targets for EC in the future.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12030660