Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design

COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major structural component of the virion and is involved in viral replication, assembly and immune regulation, plays key roles in the viral li...

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Bibliographic Details
Published in:	The EMBO journal Vol. 39; no. 20; pp. e105938 - n/a
Main Authors:	Peng, Ya, Du, Ning, Lei, Yuqing, Dorje, Sonam, Qi, Jianxun, Luo, Tingrong, Gao, George F, Song, Hao
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.10.2020 Springer Nature B.V John Wiley and Sons Inc
Subjects:	2019‐nCoV Antigenic characteristics Antigens Antiviral agents Antiviral Agents - pharmacology Antiviral drugs antivirals Assembly Betacoronavirus - chemistry Betacoronavirus - drug effects Binding sites Blocking Charge distribution Coronavirus Nucleocapsid Proteins COVID-19 Crystal structure Crystallography, X-Ray Diagnostic systems dimerization Domains Drug Delivery Systems Drug Design Drug development Drug discovery EMBO23 EMBO40 Humans Immunoregulation Life cycles Models, Molecular N protein nucleocapsid Nucleocapsid Proteins - chemistry Nucleocapsid Proteins - drug effects Nucleocapsids Oligomerization Phosphoproteins Protein Conformation Protein Domains Protein structure Proteins Recombinant Proteins - chemistry Ribonucleic acid RNA RNA binding SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Therapeutic targets Viral diseases Virions nucleocapsid dimerization antivirals 2019‐nCoV RNA binding 2019-nCoV
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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