Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

Dynactin is a 1.1 MDa complex that activates the molecular motor dynein for ultra‐processive transport along microtubules. In order to do this, it forms a tripartite complex with dynein and a coiled‐coil adaptor. Dynactin consists of an actin‐related filament whose length is defined by its flexible...

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Veröffentlicht in:	The EMBO journal Jg. 40; H. 8; S. e106164 - n/a
Hauptverfasser:	Lau, Clinton K, O’Reilly, Francis J, Santhanam, Balaji, Lacey, Samuel E, Rappsilber, Juri, Carter, Andrew P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 15.04.2021 Springer Nature B.V John Wiley and Sons Inc
Schlagworte:	Actin Adapters Adaptor proteins Cargo cargo adaptors Coils conservation Cryoelectron Microscopy cryo‐electron microscopy Datasets Domains Dynactin Dynactin Complex - chemistry Dynactin Complex - metabolism Dynein Electron microscopy EMBO05 EMBO40 Heat treating Humans Microtubules Molecular Dynamics Simulation Molecular motors Molecular structure protein complex Protein Domains Protein Multimerization Protein Subunits - chemistry Protein Subunits - metabolism Signal classification Subtraction conservation cryo‐electron microscopy dynactin protein complex cargo adaptors cryo-electron microscopy
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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