Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer

The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the development of stromal‐targeted therapies. Single‐cell RNA sequencing of five TNBCs revealed two cancer‐associated fibroblast...

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Bibliographic Details
Published in:	The EMBO journal Vol. 39; no. 19; pp. e104063 - n/a
Main Authors:	Wu, Sunny Z, Roden, Daniel L, Wang, Chenfei, Holliday, Holly, Harvey, Kate, Cazet, Aurélie S, Murphy, Kendelle J, Pereira, Brooke, Al‐Eryani, Ghamdan, Bartonicek, Nenad, Hou, Rui, Torpy, James R, Junankar, Simon, Chan, Chia‐Ling, Lam, Chuan En, Hui, Mun N, Gluch, Laurence, Beith, Jane, Parker, Andrew, Robbins, Elizabeth, Segara, Davendra, Mak, Cindy, Cooper, Caroline, Warrier, Sanjay, Forrest, Alistair, Powell, Joseph, O'Toole, Sandra, Cox, Thomas R, Timpson, Paul, Lim, Elgene, Liu, X Shirley, Swarbrick, Alexander
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2020 Springer Nature B.V John Wiley and Sons Inc
Subjects:	Breast cancer cancer‐associated fibroblasts Carcinogenesis Carcinogens Cell differentiation Crosstalk Cytotoxicity Development strategies EMBO03 EMBO19 Extracellular matrix Extracellular Matrix - immunology Extracellular Matrix - pathology Female Fibroblasts Gene expression Gene sequencing Growth factors Heterogeneity Humans Immune evasion Immune system Immunomodulation Immunomodulators Immunoregulation Inflammation Phenotypes Resource Ribonucleic acid RNA RNA-Seq Signatures single‐cell RNA sequencing Stromal Cells - immunology Stromal Cells - pathology stromal heterogeneity Subpopulations Surface markers T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - pathology Triple Negative Breast Neoplasms - immunology Triple Negative Breast Neoplasms - pathology triple‐negative breast cancer Tumor Escape Tumors tumour microenvironment tumour microenvironment cancer‐associated fibroblasts triple‐negative breast cancer stromal heterogeneity single‐cell RNA sequencing single-cell RNA sequencing cancer-associated fibroblasts triple-negative breast cancer
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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