Motor and non-motor wearing-off and its impact in the quality of life of patients with Parkinson's disease

ABSTRACT The wearing-off phenomenon is common in patients with Parkinson's disease. Motor and non-motor symptoms can fluctuate in relation to the “on/off” periods. Objective: To assess the impact of motor and non-motor wearing-off on activities of daily living and quality of life of patients wi...

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Published in:Arquivos de neuro-psiquiatria Vol. 76; no. 8; pp. 517 - 521
Main Authors: Rodríguez-Violante, Mayela, Ospina-García, Natalia, Dávila-Avila, Ned Merari, Cruz-Fino, Diego, Cruz-Landero, Alejandra de la, Cervantes-Arriaga, Amin
Format: Journal Article
Language:English
Published: Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Thieme Revinter Publicações Ltda 01.08.2018
Arquivos de Neuro-Psiquiatria
Academia Brasileira de Neurologia - ABNEURO
Thieme Revinter Publicações
Subjects:
Activities of daily living
atividades cotidianas
doença de Parkinson
Movement disorders
NEUROSCIENCES
Parkinson's disease
PSYCHIATRY
qualidade de vida
Quality of life
Parkinson disease
qualidade de vida
doença de Parkinson
quality of life
activities of daily living
atividades cotidianas
ISSN:0004-282X, 1678-4227, 1678-4227
Online Access:Get full text
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Summary:ABSTRACT The wearing-off phenomenon is common in patients with Parkinson's disease. Motor and non-motor symptoms can fluctuate in relation to the “on/off” periods. Objective: To assess the impact of motor and non-motor wearing-off on activities of daily living and quality of life of patients with PD. Methods: A cross-sectional study was carried out. All patients were evaluated using the Movement Disorders Society Unified Parkinson's Disease Rating Scale. Wearing-off was assessed using the Wearing-Off Questionnaire-19, and quality of life was assessed using the Parkinson's Disease Questionnaire-8. Results: A total of 271 patients were included; 73.4% had wearing-off; 46.8% had both motor and non-motor fluctuations. Patients with both motor and non-motor wearing-off had a worst quality of life compared with those with only motor fluctuations (p = 0.047). Conclusions: Motor and non-motor fluctuations have an impact on activities of daily living and quality of life. Non-motor wearing-off may have a higher impact.
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ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/0004-282X20180074