SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits

Measurement error and biological variability generate distortions in quantitative phenotypic data. In longitudinal studies with repeated measurements, the multiple measurements provide a route to reduce noise and correspondingly increase the strength of signals in genome-wide association studies (GW...

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Bibliographic Details
Published in:	European journal of human genetics : EJHG Vol. 21; no. 6; pp. 673 - 679
Main Authors:	Meirelles, Osorio D, Ding, Jun, Tanaka, Toshiko, Sanna, Serena, Yang, Hsih-Te, Dudekula, Dawood B, Cucca, Francesco, Ferrucci, Luigi, Abecasis, Goncalo, Schlessinger, David
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.06.2013
Subjects:	Atrophy Bayes Theorem Bayesian analysis Blood pressure Computer Simulation Databases, Genetic Genetics Genome-Wide Association Study Genomes Humans Internet Italy Lod Score Mathematical models Meta-Analysis as Topic Noise reduction Polymorphism, Single Nucleotide - genetics Quantitative Trait, Heritable Reproducibility of Results Software Studies Italy United States > US Baltimore Maryland
ISSN:	1018-4813, 1476-5438, 1476-5438
Online Access:	Get full text
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