Slow wave activity across sleep-night could predict levodopa-induced dyskinesia

A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s ap...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; pp. 15468 - 5
Main Authors:	Amato, Ninfa, Caverzasio, Serena, Manconi, Mauro, Staedler, Claudio, Kaelin-Lang, Alain, Galati, Salvatore
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/378/1385/2641 631/378/1689/1718 Dyskinesia Humanities and Social Sciences Levodopa Movement disorders multidisciplinary Neurodegeneration Neurodegenerative diseases Parkinson's disease Physiology Regression analysis Science Science (multidisciplinary) Sleep Synaptogenesis
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development.
AbstractList	Abstract A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development. A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development. A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID's appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development.A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID's appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development.
ArticleNumber	15468
Author	Manconi, Mauro Kaelin-Lang, Alain Staedler, Claudio Amato, Ninfa Caverzasio, Serena Galati, Salvatore
Author_xml	– sequence: 1 givenname: Ninfa surname: Amato fullname: Amato, Ninfa organization: Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC – sequence: 2 givenname: Serena surname: Caverzasio fullname: Caverzasio, Serena organization: Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC, Faculty of Biomedical Sciences, Università Della Svizzera Italiana (USI) – sequence: 3 givenname: Mauro surname: Manconi fullname: Manconi, Mauro organization: Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC, Faculty of Biomedical Sciences, Università Della Svizzera Italiana (USI), Department of Neurology, Inselspital, Bern University Hospital – sequence: 4 givenname: Claudio surname: Staedler fullname: Staedler, Claudio organization: Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC – sequence: 5 givenname: Alain surname: Kaelin-Lang fullname: Kaelin-Lang, Alain organization: Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC, Faculty of Biomedical Sciences, Università Della Svizzera Italiana (USI), Department of Neurology, Inselspital, Bern University Hospital – sequence: 6 givenname: Salvatore orcidid: 0000-0002-2062-166X surname: Galati fullname: Galati, Salvatore email: salvatore.galati@eoc.ch organization: Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC, Faculty of Biomedical Sciences, Università Della Svizzera Italiana (USI)
BookMark	eNp9ks1vFCEYxompsbX2H_A0iRcvo3wNHydjmqpNmvSgngkL72xZZ2GEmW32v5fdqdH2UC4Q-D0PLy_Pa3QSUwSE3hL8gWCmPhZOOq1aTFnLqcC8JS_QGcW8aymj9OS_9Sm6KGWD6-io5kS_QqdMSiqY7M7Q7fch3Tf3dgeNdVPYhWlfFzmV0pQBYGxjWN9NjUvz4Jsxgw9uagbYJZ9G24boZwe-8fvyK0Qowb5BL3s7FLh4mM_Rzy9XPy6_tTe3X68vP9-0riNqaq1k2BPW-w4kXvkV6ZnWnoLD4GUvGGAtnQSmueW9pJL33HsPpKJOCALsHF0vvj7ZjRlz2Nq8N8kGc9xIeW1snoIbwPSaMUyYgE55LqRaeeK0VLV9tSPOqer1afEa59UWvIM4ZTs8Mn18EsOdWaedIbjDmmhSHd4_OOT0e4YymW0oDobBRkhzMVQJIQXGUlf03RN0k-Yca6-OFO2U4qJSaqGOX5GhNy5MdgrpUEAY6s3mkAKzpMDUFJhjCsyhFvpE-vchz4rYIioVjmvI_6p6RvUH9prFxA
CitedBy_id	crossref_primary_10_1016_j_jsmc_2025_05_005
Cites_doi	10.1016/S1474-4422(10)70218-0 10.1038/nn.4306 10.1002/ana.25364 10.1002/ana.25459 10.1126/science.1241224 10.1002/ana.25360 10.1016/j.neubiorev.2019.05.016 10.1016/j.neuron.2013.12.025 10.1016/j.neurobiolaging.2014.12.018 10.1002/mds.28562
ContentType	Journal Article
Copyright	The Author(s) 2023 Springer Nature Limited 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023. Springer Nature Limited. Springer Nature Limited 2023
Copyright_xml	– notice: The Author(s) 2023 – notice: Springer Nature Limited 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023. Springer Nature Limited. – notice: Springer Nature Limited 2023
DBID	C6C AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 5PM DOA
DOI	10.1038/s41598-023-42604-1
DatabaseName	Springer Nature OA Free Journals (WRLC) CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database MEDLINE - Academic CrossRef
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2045-2322
EndPage	5
ExternalDocumentID	oai_doaj_org_article_f9330136e58d4678bd1c978159005cc8 PMC10509191 10_1038_s41598_023_42604_1
GrantInformation_xml	– fundername: Parkinson Schweiz funderid: http://dx.doi.org/10.13039/501100022222 – fundername: ;
GroupedDBID	0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFFHD AFPKN CITATION PHGZM PHGZT PJZUB PPXIY PQGLB 7XB 8FK K9. PKEHL PQEST PQUKI Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c518t-a730d13fd5e70bdb1f399d2ec0ed7f63e097c7e394a4f7274f4ddde1bdbc661e3
IEDL.DBID	M2P
ISICitedReferencesCount	2
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001089134700044&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2045-2322
IngestDate	Fri Oct 03 12:41:07 EDT 2025 Tue Nov 04 02:06:17 EST 2025 Fri Sep 05 11:45:01 EDT 2025 Tue Oct 07 09:21:58 EDT 2025 Tue Nov 18 22:06:34 EST 2025 Sat Nov 29 06:05:14 EST 2025 Fri Feb 21 02:37:21 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c518t-a730d13fd5e70bdb1f399d2ec0ed7f63e097c7e394a4f7274f4ddde1bdbc661e3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0002-2062-166X
OpenAccessLink	https://www.proquest.com/docview/2866258846?pq-origsite=%requestingapplication%
PMID	37726375
PQID	2866258846
PQPubID	2041939
PageCount	5
ParticipantIDs	doaj_primary_oai_doaj_org_article_f9330136e58d4678bd1c978159005cc8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10509191 proquest_miscellaneous_2866760079 proquest_journals_2866258846 crossref_citationtrail_10_1038_s41598_023_42604_1 crossref_primary_10_1038_s41598_023_42604_1 springer_journals_10_1038_s41598_023_42604_1
PublicationCentury	2000
PublicationDate	2023-09-19
PublicationDateYYYYMMDD	2023-09-19
PublicationDate_xml	– month: 09 year: 2023 text: 2023-09-19 day: 19
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London
PublicationTitle	Scientific reports
PublicationTitleAbbrev	Sci Rep
PublicationYear	2023
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio
References	CR11 Calabresi, Di Filippo, Ghiglieri, Tambasco, Picconi (CR1) 2010; 9 Tononi, Cirelli (CR3) 2014; 81 Espay, Morgante, Merola, Fasano, Marsili, Fox, Bezard, Picconi, Calabresi, Land (CR8) 2018; 84 CR4 Galati, Salvade, Pace, Sarasso, Baracchi, Bassetti, Kaelin-Lang, Stadler, Stanzione, Moller (CR5) 2015; 36 Xie, Kang, Xu, Chen, Liao, Thiyagarajan, O’Donnell, Christensen, Nicholson, Iliff (CR9) 2013; 80 Schreiner, Imbach, Werth, Poryazova, Baumann-Vogel, Valko, Murer, Noain, Baumann (CR7) 2019; 85 Amato, Manconi, Möller, Sarasso, Stanzione, Staedler, KaelinLang, Galati (CR6) 2018 Calabresi, Pisani, Rothwell, Ghiglieri, Obeso, Picconi (CR2) 2016 Grimalsi, Papalambros, Zee, Malkani (CR12) 2020; 141 Sundaram, Hughes, Peterson, Muller-Oehring, Bronte-Stewart, Poston, Faerman, Bhomwick, Schulte (CR10) 2019; 103 S Galati (42604_CR5) 2015; 36 42604_CR4 AJ Espay (42604_CR8) 2018; 84 S Sundaram (42604_CR10) 2019; 103 SJ Schreiner (42604_CR7) 2019; 85 P Calabresi (42604_CR2) 2016 42604_CR11 P Calabresi (42604_CR1) 2010; 9 G Tononi (42604_CR3) 2014; 81 L Xie (42604_CR9) 2013; 80 N Amato (42604_CR6) 2018 D Grimalsi (42604_CR12) 2020; 141
References_xml	– volume: 9 start-page: 1106 year: 2010 end-page: 1117 ident: CR1 article-title: Levodopa-induced dyskinesias in patients with Parkinson’s disease: filling the bench-to-bedside gap publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(10)70218-0 – year: 2016 ident: CR2 article-title: Hyperkinetic disorders and loss of synaptic downscaling publication-title: Nat. Neurosci. doi: 10.1038/nn.4306 – volume: 84 start-page: 797 issue: 6 year: 2018 end-page: 811 ident: CR8 article-title: Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts publication-title: Ann. Neurol. doi: 10.1002/ana.25364 – volume: 85 start-page: 765 year: 2019 end-page: 770 ident: CR7 article-title: Slow-wave sleep and motor progression in Parkinson disease publication-title: Ann. Neurol. doi: 10.1002/ana.25459 – volume: 80 start-page: 373 issue: 342 year: 2013 end-page: 377 ident: CR9 article-title: Sleep drives metabolite clearance from the adult brain publication-title: Science doi: 10.1126/science.1241224 – year: 2018 ident: CR6 article-title: Levodopa-induced dyskinesia in Parkinson’s disease: sleep matters publication-title: Ann. Neurol. doi: 10.1002/ana.25360 – ident: CR4 – volume: 103 start-page: 305 year: 2019 end-page: 331 ident: CR10 article-title: Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease publication-title: Neurosci Biobehav Rev. doi: 10.1016/j.neubiorev.2019.05.016 – volume: 141 start-page: 1 year: 2020 end-page: 16 ident: CR12 article-title: Neurostimulation techniques to enhance sleep and improve cognition in aging publication-title: Neurobiol. Dis. – volume: 81 start-page: 12 year: 2014 end-page: 34 ident: CR3 article-title: Sleep and the price of plasticity: From synaptic and cellular homeostasis to memory consolidation and integration publication-title: Neuron doi: 10.1016/j.neuron.2013.12.025 – volume: 36 start-page: 1577 year: 2015 end-page: 1589 ident: CR5 article-title: Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson’s disease publication-title: Neurobiol. Aging. doi: 10.1016/j.neurobiolaging.2014.12.018 – ident: CR11 – volume: 84 start-page: 797 issue: 6 year: 2018 ident: 42604_CR8 publication-title: Ann. Neurol. doi: 10.1002/ana.25364 – volume: 85 start-page: 765 year: 2019 ident: 42604_CR7 publication-title: Ann. Neurol. doi: 10.1002/ana.25459 – ident: 42604_CR11 – ident: 42604_CR4 doi: 10.1002/mds.28562 – volume: 81 start-page: 12 year: 2014 ident: 42604_CR3 publication-title: Neuron doi: 10.1016/j.neuron.2013.12.025 – volume: 141 start-page: 1 year: 2020 ident: 42604_CR12 publication-title: Neurobiol. Dis. – volume: 9 start-page: 1106 year: 2010 ident: 42604_CR1 publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(10)70218-0 – volume: 36 start-page: 1577 year: 2015 ident: 42604_CR5 publication-title: Neurobiol. Aging. doi: 10.1016/j.neurobiolaging.2014.12.018 – year: 2018 ident: 42604_CR6 publication-title: Ann. Neurol. doi: 10.1002/ana.25360 – volume: 80 start-page: 373 issue: 342 year: 2013 ident: 42604_CR9 publication-title: Science doi: 10.1126/science.1241224 – year: 2016 ident: 42604_CR2 publication-title: Nat. Neurosci. doi: 10.1038/nn.4306 – volume: 103 start-page: 305 year: 2019 ident: 42604_CR10 publication-title: Neurosci Biobehav Rev. doi: 10.1016/j.neubiorev.2019.05.016
SSID	ssj0000529419
Score	2.4118462
Snippet	A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced... Abstract A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting...
SourceID	doaj pubmedcentral proquest crossref springer
SourceType	Open Website Open Access Repository Aggregation Database Enrichment Source Index Database Publisher
StartPage	15468
SubjectTerms	631/378/1385/2641 631/378/1689/1718 Dyskinesia Humanities and Social Sciences Levodopa Movement disorders multidisciplinary Neurodegeneration Neurodegenerative diseases Parkinson's disease Physiology Regression analysis Science Science (multidisciplinary) Sleep Synaptogenesis
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA9yKPgifmLPUyr4puE2Sdskj6d4-CCnoMK9hTSZ4OLSXbZ7e9x_fzNpd70eqC--lXZKkvlIZpjMbxh700prRO1x95Pe8ipC4iZazUPbAAitpEi5UPizPjsz5-f2641WX3QnbIAHHhh3nCjiFqqB2kQ0atNGEQinibpd1iHkMt-ZtjeCqQHVW9pK2LFKZqbMcY8nFVWTScUJlL3iYnISZcD-iZd5-47krURpPn9OH7IHo-NYngwTfsTuQPeY3RtaSV49YV--LZaX5aXfQkmlCtQRAh9o4LJfAKx4RgwpA3W0LldrSs9sygVsMSpdeY6BOYo4lvGq_0X34Of-Kftx-vH7h098bJbAQy3Mhns01ShUijXoWRtbkdD1iBLCDKJOjYKZ1UGDspWvEjotVaoibm0CSQOe0aCesYNu2cFzVkJq0G_0WqIgq9QaS6nO2DZBeRmEbgsmdoxzYUQSp4YWC5cz2sq4gdkOme0ys50o2Nv9P6sBR-Ov1O9JHntKwsDOL1Az3KgZ7l-aUbCjnTTdaJi9k6bBiM-g11Ww1_vPaFKUJ_EdLC8GGspXalswM9GCyYSmX7r5zwzOLQhQB4Pggr3bKczv0f-84sP_seIX7L4kBacOF_aIHWzWF_CS3Q3bzbxfv8oWcg2rrhM- priority: 102 providerName: Directory of Open Access Journals
Title	Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
URI	https://link.springer.com/article/10.1038/s41598-023-42604-1 https://www.proquest.com/docview/2866258846 https://www.proquest.com/docview/2866760079 https://pubmed.ncbi.nlm.nih.gov/PMC10509191 https://doaj.org/article/f9330136e58d4678bd1c978159005cc8
Volume	13
WOSCitedRecordID	wos001089134700044&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M2P dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xFSRe-EYERhUk3sBaHaex84QY2gQSKxEfUnmKHNsZFVUSmq7T_nvunLRTJrEXXqyocVQnd-c739m_H8DrIkoVn2qc_SKdsti6kimbSmaKxDkuRcRLf1D4s5zN1HyeZn3Cre23VW7nRD9R29pQjvwwUgmG6grd5bvmDyPWKKqu9hQaezDCyIbTlq7TKNvlWKiKFfO0PyszEeqwRX9FZ8oiwQiaPWZ84I88bP8g1ry-U_JaudR7oZP7_zv-B3Cvjz_D953CPIRbrnoEdzpGysvH8OXbsr4IL_TGhXTigYgl8IJGHrZL5xrmgUdCQ8TYYbOiKs86XLoNLm4bzXB9j5piQ3vZ_qbt9Av9BH6cHH__8JH1nAvM4PdbM40Wb7ko7dTJSWELXmIEYyNnJs7KMhFukkojnUhjHZcY-8RlbHGG5NjVoKt34insV3XlnkHoygTDTy0j1Ie4LFRKFVNbJEboyHBZBMC3Xz43PSA58WIsc18YFyrvpJWjtHIvrZwH8Gb3TNPBcdzY-4gEuutJUNr-h3p1lveWmZeU0uEicVNl0WuownJDQGBEpzo1RgVwsBVo3tt3m19JM4BXu9tomVRu0ZWrz7s-VPaUaQBqoEaDAQ3vVItfHuObEy4PrqUDeLvVuKt___cbP795sC_gbkS6TxQY6QHsr1fn7iXcNpv1ol2NYU_OpW_VGEZHx7Ps69jnKMberKiV2I6yT6fZz792Jym9
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoILb0SgQJDgBFbXzss-IMSratVlqUSRenMT26GrrpKw2e5q_xS_kZk8ttpK9NYDtyhxHrY_zzgez_cBvM6EkjxK0fqJVLHQupxJqxJmstg5ngSC502i8DAZjeTRkTrYgD99Lgxtq-xtYmOobWlojXxbyBin6hLd5YfqNyPVKIqu9hIaLSz23XKBv2z1-70v2L9vhNj5evh5l3WqAsxEXM5Yipi2PMht5JJBZjOeo4-2wpmBs0keB26gEpO4QIVpmKN3D_PQog3gWNSgM3MBPvcaXA-JWYy2CoqD1ZoORc1CrrrcnEEgt2v0j5TDJgJGVPAh42v-r5EJWJvbXtyZeSE823i9nbv_W3vdgzvd_Nr_2A6I-7Dhigdws1XcXD6E7z8m5cJfpHPnU0YHCWfgAbWUX0-cq1hDrOIbEv72qylFsWb-xM3x571K2biwOBKsb5f1KaULjNNH8PNKavMYNouycE_Ad3mM0-s0EYj3MM-kooiwzWITpMLwJPOA9z2tTUe4TrofE90E_gOpW3RoRIdu0KG5B29X91Qt3cilpT8RgFYliSq8OVFOf-nO8uiclqx4ELtIWvSKMrPcENEZycVGxkgPtnoA6c5-1focPR68Wl1Gy0PhpLRw5VlbhsK6ifJArsF27YPWrxTjk4bDnBPvEFdYhXc9ws_f_u8aP738Y1_Crd3Db0M93BvtP4PbgsYdyX2oLdicTc_cc7hh5rNxPX3RDFwfjq8a-X8BT66Cyg
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFBAX3qiBAkaCE6ySXTv27gEhoERELSESIJXTYu-DRkROiNNE-Wv8Omb8SJVK9NYDN8teP3b3m4d3duYDeJ4JJXkvRe0nUsUi6zyTViXMZLFzPAkF92Wi8FEyHMrjYzXagT9NLgxtq2x0Yqmo7dTQGnlHyBhddYnmsuPrbRGjg_6b2W9GDFIUaW3oNCqIHLr1Cn_fiteDA5zrF0L0P3x9_5HVDAPM9LhcsBTxbXnobc8l3cxm3KO9tsKZrrOJj0PXVYlJXKiiNPJo6SMfWdQHHJsaNGwuxOdegV10ySPRgt3R4NPo-2aFh2JoEVd1pk43lJ0CrSVltImQUWH4iPEta1iSBmx5uuf3aZ4L1pY2sH_rfx6923Cz9ryDt5Wo3IEdl9-FaxUX5_oefP4yma6CVbp0AeV6EKUGHtCoBcXEuRkrS64EhijBg9mc4luLYOKW-Fs_S9k4tygjNrDr4hclEozT-_DtUnrzAFr5NHd7EDgfo-OdJgIlIfKZVBQrtllswlQYnmRt4M2sa1OXYidGkIkutwSEUldI0YgUXSJF8za83NwzqwqRXNj6HYFp05KKiJcnpvOfutZJ2tNiFg9j15MW7aXMLDdUAo2IZHvGyDbsN2DStWYr9BmS2vBscxl1EgWa0txNT6s2FPBNVBvkFoS3Pmj7Sj4-Kaubc6pIxBV24VWD9rO3_7vHDy_-2KdwHQGvjwbDw0dwQ5AIEg-I2ofWYn7qHsNVs1yMi_mTWooD-HHZ0P8LACKNEw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Slow+wave+activity+across+sleep-night+could+predict+levodopa-induced+dyskinesia&rft.jtitle=Scientific+reports&rft.au=Amato%2C+Ninfa&rft.au=Caverzasio%2C+Serena&rft.au=Manconi%2C+Mauro&rft.au=Staedler%2C+Claudio&rft.date=2023-09-19&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-023-42604-1&rft.externalDocID=10_1038_s41598_023_42604_1
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon