Slow wave activity across sleep-night could predict levodopa-induced dyskinesia

A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s ap...

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Published in:Scientific reports Vol. 13; no. 1; pp. 15468 - 5
Main Authors: Amato, Ninfa, Caverzasio, Serena, Manconi, Mauro, Staedler, Claudio, Kaelin-Lang, Alain, Galati, Salvatore
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 19.09.2023
Nature Publishing Group
Nature Portfolio
Subjects:
631/378/1385/2641
631/378/1689/1718
Dyskinesia
Humanities and Social Sciences
Levodopa
Movement disorders
multidisciplinary
Neurodegeneration
Neurodegenerative diseases
Parkinson's disease
Physiology
Regression analysis
Science
Science (multidisciplinary)
Sleep
Synaptogenesis
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-42604-1