Structures of Naturally Evolved CUP1 Tandem Arrays in Yeast Indicate That These Arrays Are Generated by Unequal Nonhomologous Recombination

Abstract An important issue in genome evolution is the mechanism by which tandem duplications are generated from single-copy genes. In the yeast Saccharomyces cerevisiae, most strains contain tandemly duplicated copies of CUP1, a gene that encodes a copper-binding metallothionein. By screening 101 n...

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Bibliographic Details

Published in:	G3 : genes - genomes - genetics Vol. 4; no. 11; pp. 2259 - 2269
Main Authors:	Zhao, Ying, Strope, Pooja K, Kozmin, Stanislav G, McCusker, John H, Dietrich, Fred S, Kokoska, Robert J, Petes, Thomas D
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01.11.2014 Genetics Society of America
Subjects:	Evolution, Molecular Gene Duplication Homologous Recombination Investigations Metallothionein - genetics Saccharomyces cerevisiae - genetics copper resistance recombination tandemly repeated genes Saccharomyces cerevisiae
ISSN:	2160-1836, 2160-1836
Online Access:	Get full text
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