Individual differences in T1w/T2w ratio development during childhood

Myelination is a key developmental process that promotes rapid and efficient information transfer. Myelin also stabilizes existing brain networks and thus may constrain neuroplasticity, defined here as the brain's potential to change in response to experiences rather than the canonical definiti...

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Vydané v:Developmental cognitive neuroscience Ročník 62; s. 101270
Hlavní autori: Boroshok, Austin L., McDermott, Cassidy L., Fotiadis, Panagiotis, Park, Anne T., Tooley, Ursula A., Gataviņš, Mārtiņš M., Tisdall, M. Dylan, Bassett, Dani S., Mackey, Allyson P.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier Ltd 01.08.2023
Elsevier
Predmet:
Adolescent
Brain
Child
Head
Humans
Individuality
Magnetic Resonance Imaging
Myelin Sheath
Myelination
Neurodevelopment
Original Research
Plasticity
Neurodevelopment
Myelination
Plasticity
ISSN:1878-9293, 1878-9307, 1878-9307
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Shrnutí:Myelination is a key developmental process that promotes rapid and efficient information transfer. Myelin also stabilizes existing brain networks and thus may constrain neuroplasticity, defined here as the brain's potential to change in response to experiences rather than the canonical definition as the process of change. Characterizing individual differences in neuroplasticity may shed light on mechanisms by which early experiences shape learning, brain and body development, and response to interventions. The T1-weighted/T2-weighted (T1w/T2w) MRI signal ratio is a proxy measure of cortical microstructure and thus neuroplasticity. Here, in pre-registered analyses, we investigated individual differences in T1w/T2w ratios in children (ages 4–10, n = 157). T1w/T2w ratios were positively associated with age within early-developing sensorimotor and attention regions. We also tested whether socioeconomic status, cognition (crystallized knowledge or fluid reasoning), and biological age (as measured with molar eruption) were related to T1w/T2w signal but found no significant effects. Associations among T1w/T2w ratios, early experiences, and cognition may emerge later in adolescence and may not be strong enough to detect in moderate sample sizes.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1878-9293
1878-9307
1878-9307
DOI:10.1016/j.dcn.2023.101270