Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection
Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a po...
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| Vydáno v: | Cell death & disease Ročník 14; číslo 11; s. 727 - 11 |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
Nature Publishing Group UK
09.11.2023
Springer Nature B.V Nature Publishing Group |
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| ISSN: | 2041-4889, 2041-4889 |
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| Abstract | Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a potential role for GSDMD in promoting the development of severe IAV disease. IAV infection resulted in cleavage of GSDMD in vivo and in vitro in lung epithelial cells. Mice genetically deficient in GSDMD (
Gsdmd
−/−
) developed less severe IAV disease than wildtype mice and displayed improved survival outcomes. GSDMD deficiency significantly reduced neutrophil infiltration into the airways as well as the levels of pro-inflammatory cytokines TNF, IL-6, MCP-1, and IL-1α and neutrophil-attracting chemokines CXCL1 and CXCL2. In contrast, IL-1β and IL-18 responses were not largely impacted by GSDMD deficiency. In addition,
Gsdmd
−/−
mice displayed significantly improved influenza disease resistance with reduced viral burden and less severe pulmonary pathology, including decreased epithelial damage and cell death. These findings indicate a major role for GSDMD in promoting damaging inflammation and the development of severe IAV disease. |
|---|---|
| AbstractList | Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a potential role for GSDMD in promoting the development of severe IAV disease. IAV infection resulted in cleavage of GSDMD in vivo and in vitro in lung epithelial cells. Mice genetically deficient in GSDMD (
Gsdmd
−/−
) developed less severe IAV disease than wildtype mice and displayed improved survival outcomes. GSDMD deficiency significantly reduced neutrophil infiltration into the airways as well as the levels of pro-inflammatory cytokines TNF, IL-6, MCP-1, and IL-1α and neutrophil-attracting chemokines CXCL1 and CXCL2. In contrast, IL-1β and IL-18 responses were not largely impacted by GSDMD deficiency. In addition,
Gsdmd
−/−
mice displayed significantly improved influenza disease resistance with reduced viral burden and less severe pulmonary pathology, including decreased epithelial damage and cell death. These findings indicate a major role for GSDMD in promoting damaging inflammation and the development of severe IAV disease. Abstract Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a potential role for GSDMD in promoting the development of severe IAV disease. IAV infection resulted in cleavage of GSDMD in vivo and in vitro in lung epithelial cells. Mice genetically deficient in GSDMD (Gsdmd −/−) developed less severe IAV disease than wildtype mice and displayed improved survival outcomes. GSDMD deficiency significantly reduced neutrophil infiltration into the airways as well as the levels of pro-inflammatory cytokines TNF, IL-6, MCP-1, and IL-1α and neutrophil-attracting chemokines CXCL1 and CXCL2. In contrast, IL-1β and IL-18 responses were not largely impacted by GSDMD deficiency. In addition, Gsdmd −/− mice displayed significantly improved influenza disease resistance with reduced viral burden and less severe pulmonary pathology, including decreased epithelial damage and cell death. These findings indicate a major role for GSDMD in promoting damaging inflammation and the development of severe IAV disease. Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a potential role for GSDMD in promoting the development of severe IAV disease. IAV infection resulted in cleavage of GSDMD in vivo and in vitro in lung epithelial cells. Mice genetically deficient in GSDMD (Gsdmd−/−) developed less severe IAV disease than wildtype mice and displayed improved survival outcomes. GSDMD deficiency significantly reduced neutrophil infiltration into the airways as well as the levels of pro-inflammatory cytokines TNF, IL-6, MCP-1, and IL-1α and neutrophil-attracting chemokines CXCL1 and CXCL2. In contrast, IL-1β and IL-18 responses were not largely impacted by GSDMD deficiency. In addition, Gsdmd−/− mice displayed significantly improved influenza disease resistance with reduced viral burden and less severe pulmonary pathology, including decreased epithelial damage and cell death. These findings indicate a major role for GSDMD in promoting damaging inflammation and the development of severe IAV disease. Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a potential role for GSDMD in promoting the development of severe IAV disease. IAV infection resulted in cleavage of GSDMD in vivo and in vitro in lung epithelial cells. Mice genetically deficient in GSDMD (Gsdmd-/-) developed less severe IAV disease than wildtype mice and displayed improved survival outcomes. GSDMD deficiency significantly reduced neutrophil infiltration into the airways as well as the levels of pro-inflammatory cytokines TNF, IL-6, MCP-1, and IL-1α and neutrophil-attracting chemokines CXCL1 and CXCL2. In contrast, IL-1β and IL-18 responses were not largely impacted by GSDMD deficiency. In addition, Gsdmd-/- mice displayed significantly improved influenza disease resistance with reduced viral burden and less severe pulmonary pathology, including decreased epithelial damage and cell death. These findings indicate a major role for GSDMD in promoting damaging inflammation and the development of severe IAV disease.Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin D (GSDMD). In this study, we investigated a potential role for GSDMD in promoting the development of severe IAV disease. IAV infection resulted in cleavage of GSDMD in vivo and in vitro in lung epithelial cells. Mice genetically deficient in GSDMD (Gsdmd-/-) developed less severe IAV disease than wildtype mice and displayed improved survival outcomes. GSDMD deficiency significantly reduced neutrophil infiltration into the airways as well as the levels of pro-inflammatory cytokines TNF, IL-6, MCP-1, and IL-1α and neutrophil-attracting chemokines CXCL1 and CXCL2. In contrast, IL-1β and IL-18 responses were not largely impacted by GSDMD deficiency. In addition, Gsdmd-/- mice displayed significantly improved influenza disease resistance with reduced viral burden and less severe pulmonary pathology, including decreased epithelial damage and cell death. These findings indicate a major role for GSDMD in promoting damaging inflammation and the development of severe IAV disease. |
| ArticleNumber | 727 |
| Author | Rosli, Sarah Hodges, Christopher Tate, Michelle D. West, Alison C. Lawlor, Kate E. Harpur, Christopher M. Mansell, Ashley Lam, Maggie |
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| Cites_doi | 10.1371/journal.ppat.1003392 10.1080/21505594.2021.1939608 10.4049/jimmunol.0902497 10.1179/2047773213Y.0000000103 10.1074/jbc.M116.756379 10.3390/v12040401 10.1016/j.immuni.2017.11.013 10.1038/nature14348 10.1136/bmj.i3077 10.1016/j.cell.2013.06.013 10.1038/srep27912 10.1089/vim.2010.0118 10.1038/s41577-021-00498-y 10.1038/s41392-021-00507-5 10.1371/journal.ppat.1010395 10.1038/nature15541 10.1002/cti2.1443 10.1038/nature15514 10.1111/bph.14787 10.1111/imcb.12459 10.1371/journal.pone.0017618 10.1099/vir.0.045021-0 10.1016/S1473-3099(13)70286-X 10.1002/eji.201747404 10.1128/JVI.00396-18 10.1016/j.celrep.2021.108887 10.1084/jem.73.1.43 10.1128/JVI.00291-10 10.1038/s41586-021-03218-7 10.1126/science.abi5934 10.1038/cddiscovery.2017.70 10.1038/cr.2015.139 10.1038/srep07176 10.1038/ni.1861 10.3390/v6031294 10.1189/jlb.4MR0616-288R 10.1016/j.micinf.2010.10.004 10.1093/intimm/dxz070 |
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| References | Heilig, Dick, Sborgi, Meunier, Hiller, Broz (CR14) 2018; 48 McAuley, Tate, MacKenzie-Kludas, Pinar, Zeng, Stutz (CR4) 2013; 9 Thomas, Porritt, Hertzog, Bardin, Tate (CR18) 2014; 4 Tsuchiya, Hosojima, Hara, Kushiyama, Mahib, Kinoshita (CR37) 2021; 34 Yu, Zhang, Liu, Tang, Peng, Chen (CR23) 2021; 6 Hawkes (CR26) 2016; 353 Brandes, Klauschen, Kuchen, Germain (CR34) 2013; 154 Tate, Pickett, van Rooijen, Brooks, Reading (CR21) 2010; 84 Evavold, Ruan, Tan, Xia, Wu, Kagan (CR12) 2018; 48 Doherty (CR1) 2021; 21 Pinar, Dowling, Bitto, Robertson, Latz, Stewart (CR5) 2017; 292 Bawazeer, Rosli, Harpur, Docherty, Mansell, Tate (CR9) 2021; 99 Harpur, West, Le Page, Lam, Hodges, Oseghale (CR17) 2023; 12 Shi, Zhao, Wang, Shi, Wang, Huang (CR11) 2015; 526 Tate, Deng, Jones, Anderson, Brooks, Reading (CR19) 2009; 183 Tate, Job, Deng, Gunalan, Maurer-Stroh, Reading (CR29) 2014; 6 Tate, Ioannidis, Croker, Brown, Brooks, Reading (CR33) 2011; 6 Harpur, Le Page, Tate (CR28) 2021; 12 Laghlali, Lawlor, Tate (CR3) 2020; 12 Poovorawan, Pyungporn, Prachayangprecha, Makkoch (CR25) 2013; 107 Tate, Ong, Dowling, McAuley, Robertson, Latz (CR8) 2016; 6 Ong, Mansell, Tate (CR2) 2017; 101 Tate, Schilter, Brooks, Reading (CR20) 2011; 24 Newton, Dixit, Kayagaki (CR10) 2021; 374 Short, Kroeze, Fouchier, Kuiken (CR27) 2014; 14 Ichinohe, Pang, Iwasaki (CR6) 2010; 11 Taylor (CR31) 1941; 73 Momota, Lelliott, Kubo, Kusakabe, Kobiyama, Kuroda (CR38) 2020; 32 Lam, Zhou, Wang, Chai, Shen, Chen (CR24) 2015; 522 Corry, Kettenburg, Upadhyay, Wallace, Marti, Wonderlich (CR15) 2022; 18 Tate, Brooks, Reading (CR22) 2011; 13 Rosli, Kirby, Lawlor, Rainczuk, Drummond, Mansell (CR7) 2019; 176 He, Wan, Hu, Chen, Wang, Huang (CR13) 2015; 25 Kayagaki, Stowe, Lee, O’Rourke, Anderson, Warming (CR16) 2015; 526 Short, Brooks, Reading, Londrigan (CR30) 2012; 93 Lee, Hirohama, Noguchi, Nagata, Kawaguchi (CR32) 2018; 92 Kayagaki, Kornfeld, Lee, Stowe, O’Rourke, Li (CR36) 2021; 591 DiPeso, Ji, Vance, Price (CR35) 2017; 3 G Laghlali (6258_CR3) 2020; 12 AO Bawazeer (6258_CR9) 2021; 99 KR Short (6258_CR27) 2014; 14 J Corry (6258_CR15) 2022; 18 MD Tate (6258_CR22) 2011; 13 MD Tate (6258_CR33) 2011; 6 JL McAuley (6258_CR4) 2013; 9 KR Short (6258_CR30) 2012; 93 WT He (6258_CR13) 2015; 25 RM Taylor (6258_CR31) 1941; 73 MD Tate (6258_CR8) 2016; 6 CM Harpur (6258_CR28) 2021; 12 K Tsuchiya (6258_CR37) 2021; 34 MD Tate (6258_CR21) 2010; 84 PC Doherty (6258_CR1) 2021; 21 MD Tate (6258_CR19) 2009; 183 N Hawkes (6258_CR26) 2016; 353 JD Ong (6258_CR2) 2017; 101 CL Evavold (6258_CR12) 2018; 48 MD Tate (6258_CR29) 2014; 6 TT Lam (6258_CR24) 2015; 522 A Pinar (6258_CR5) 2017; 292 S Rosli (6258_CR7) 2019; 176 CM Harpur (6258_CR17) 2023; 12 Y Poovorawan (6258_CR25) 2013; 107 M Momota (6258_CR38) 2020; 32 L DiPeso (6258_CR35) 2017; 3 T Ichinohe (6258_CR6) 2010; 11 J Shi (6258_CR11) 2015; 526 M Brandes (6258_CR34) 2013; 154 N Kayagaki (6258_CR36) 2021; 591 K Newton (6258_CR10) 2021; 374 MD Tate (6258_CR20) 2011; 24 P Yu (6258_CR23) 2021; 6 R Heilig (6258_CR14) 2018; 48 S Lee (6258_CR32) 2018; 92 BJ Thomas (6258_CR18) 2014; 4 N Kayagaki (6258_CR16) 2015; 526 |
| References_xml | – volume: 32 start-page: 203 year: 2020 end-page: 12 ident: CR38 article-title: ZBP1 governs the inflammasome-independent IL-1alpha and neutrophil inflammation that play a dual role in anti-influenza virus immunity publication-title: Int Immunol – volume: 9 start-page: e1003392 year: 2013 ident: CR4 article-title: Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1003392 – volume: 12 start-page: 1629 year: 2021 end-page: 46 ident: CR28 article-title: Too young to die? How aging affects cellular innate immune responses to influenza virus and disease severity publication-title: Virulence doi: 10.1080/21505594.2021.1939608 – volume: 183 start-page: 7441 year: 2009 end-page: 50 ident: CR19 article-title: Neutrophils ameliorate lung injury and the development of severe disease during influenza infection publication-title: J Immunol doi: 10.4049/jimmunol.0902497 – volume: 107 start-page: 217 year: 2013 end-page: 23 ident: CR25 article-title: Global alert to avian influenza virus infection: from H5N1 to H7N9 publication-title: Pathog Glob Health doi: 10.1179/2047773213Y.0000000103 – volume: 292 start-page: 826 year: 2017 end-page: 36 ident: CR5 article-title: PB1-F2 peptide derived from avian influenza A virus H7N9 induces inflammation via activation of the NLRP3 inflammasome publication-title: J Biol Chem doi: 10.1074/jbc.M116.756379 – volume: 12 start-page: 401 year: 2020 ident: CR3 article-title: Die another way: interplay between influenza A virus, inflammation and cell death publication-title: Viruses doi: 10.3390/v12040401 – volume: 48 start-page: 35 year: 2018 end-page: 44.e36 ident: CR12 article-title: The pore-forming protein Gasdermin D regulates interleukin-1 secretion from living macrophages publication-title: Immunity doi: 10.1016/j.immuni.2017.11.013 – volume: 522 start-page: 102 year: 2015 end-page: 5 ident: CR24 article-title: Dissemination, divergence and establishment of H7N9 influenza viruses in China publication-title: Nature doi: 10.1038/nature14348 – volume: 353 start-page: i3077 year: 2016 ident: CR26 article-title: Debate on whether Tamiflu prevents flu deaths reignites after new analysis publication-title: Br Med J doi: 10.1136/bmj.i3077 – volume: 154 start-page: 197 year: 2013 end-page: 212 ident: CR34 article-title: A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection publication-title: Cell doi: 10.1016/j.cell.2013.06.013 – volume: 6 year: 2016 ident: CR8 article-title: Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition publication-title: Sci Rep doi: 10.1038/srep27912 – volume: 24 start-page: 77 year: 2011 end-page: 88 ident: CR20 article-title: Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus publication-title: Viral Immunol doi: 10.1089/vim.2010.0118 – volume: 21 start-page: 67 year: 2021 end-page: 68 ident: CR1 article-title: What have we learnt so far from COVID-19? publication-title: Nat Rev Immunol doi: 10.1038/s41577-021-00498-y – volume: 6 start-page: 128 year: 2021 ident: CR23 article-title: Pyroptosis: mechanisms and diseases publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-021-00507-5 – volume: 18 start-page: e1010395 year: 2022 ident: CR15 article-title: Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1010395 – volume: 526 start-page: 666 year: 2015 end-page: 71 ident: CR16 article-title: Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling publication-title: Nature doi: 10.1038/nature15541 – volume: 12 year: 2023 ident: CR17 article-title: Naturally derived cytokine peptides limit virus replication and severe disease during influenza A virus infection publication-title: Clin Trans Immunol doi: 10.1002/cti2.1443 – volume: 526 start-page: 660 year: 2015 end-page: 5 ident: CR11 article-title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death publication-title: Nature doi: 10.1038/nature15514 – volume: 176 start-page: 3834 year: 2019 end-page: 44 ident: CR7 article-title: Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection publication-title: Br J Pharmacol doi: 10.1111/bph.14787 – volume: 99 start-page: 737 year: 2021 end-page: 48 ident: CR9 article-title: Interleukin-1beta exacerbates disease and is a potential therapeutic target to reduce pulmonary inflammation during severe influenza A virus infection publication-title: Immunol Cell Biol doi: 10.1111/imcb.12459 – volume: 6 start-page: e17618 year: 2011 ident: CR33 article-title: The role of neutrophils during mild and severe influenza virus infections of mice publication-title: PLoS ONE doi: 10.1371/journal.pone.0017618 – volume: 93 start-page: 2315 year: 2012 end-page: 25 ident: CR30 article-title: The fate of influenza A virus after infection of human macrophages and dendritic cells publication-title: J Gen Virol doi: 10.1099/vir.0.045021-0 – volume: 14 start-page: 57 year: 2014 end-page: 69 ident: CR27 article-title: Pathogenesis of influenza-induced acute respiratory distress syndrome publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(13)70286-X – volume: 48 start-page: 584 year: 2018 end-page: 92 ident: CR14 article-title: The Gasdermin-D pore acts as a conduit for IL-1beta secretion in mice publication-title: Eur J Immunol doi: 10.1002/eji.201747404 – volume: 92 start-page: e00396 year: 2018 end-page: 00318 ident: CR32 article-title: Influenza A virus infection triggers pyroptosis and apoptosis of respiratory epithelial cells through the type I interferon signaling pathway in a mutually exclusive manner publication-title: J Virol doi: 10.1128/JVI.00396-18 – volume: 34 start-page: 108887 year: 2021 ident: CR37 article-title: Gasdermin D mediates the maturation and release of IL-1alpha downstream of inflammasomes publication-title: Cell Rep doi: 10.1016/j.celrep.2021.108887 – volume: 73 start-page: 43 year: 1941 end-page: 55 ident: CR31 article-title: Experimental infection with influenza a virus in mice: the increase in intrapulmonary virus after inoculation and the influence of various factors thereon publication-title: J Exp Med doi: 10.1084/jem.73.1.43 – volume: 84 start-page: 7569 year: 2010 end-page: 80 ident: CR21 article-title: Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice publication-title: J Virol doi: 10.1128/JVI.00291-10 – volume: 591 start-page: 131 year: 2021 end-page: 6 ident: CR36 article-title: NINJ1 mediates plasma membrane rupture during lytic cell death publication-title: Nature doi: 10.1038/s41586-021-03218-7 – volume: 374 start-page: 1076 year: 2021 end-page: 80 ident: CR10 article-title: Dying cells fan the flames of inflammation publication-title: Science doi: 10.1126/science.abi5934 – volume: 3 start-page: 17070 year: 2017 ident: CR35 article-title: Cell death and cell lysis are separable events during pyroptosis publication-title: Cell Death Discov doi: 10.1038/cddiscovery.2017.70 – volume: 25 start-page: 1285 year: 2015 end-page: 98 ident: CR13 article-title: Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion publication-title: Cell Res doi: 10.1038/cr.2015.139 – volume: 4 year: 2014 ident: CR18 article-title: Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon publication-title: Sci Rep doi: 10.1038/srep07176 – volume: 11 start-page: 404 year: 2010 end-page: 10 ident: CR6 article-title: Influenza virus activates inflammasomes via its intracellular M2 ion channel publication-title: Nat Immunol doi: 10.1038/ni.1861 – volume: 6 start-page: 1294 year: 2014 end-page: 316 ident: CR29 article-title: Playing hide and seek: how glycosylation of the influenza virus hemagglutinin can modulate the immune response to infection publication-title: Viruses doi: 10.3390/v6031294 – volume: 101 start-page: 863 year: 2017 end-page: 74 ident: CR2 article-title: Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection publication-title: J Leukoc Biol doi: 10.1189/jlb.4MR0616-288R – volume: 13 start-page: 202 year: 2011 end-page: 7 ident: CR22 article-title: Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus publication-title: Microbes Infect doi: 10.1016/j.micinf.2010.10.004 – volume: 25 start-page: 1285 year: 2015 ident: 6258_CR13 publication-title: Cell Res doi: 10.1038/cr.2015.139 – volume: 48 start-page: 584 year: 2018 ident: 6258_CR14 publication-title: Eur J Immunol doi: 10.1002/eji.201747404 – volume: 4 year: 2014 ident: 6258_CR18 publication-title: Sci Rep doi: 10.1038/srep07176 – volume: 292 start-page: 826 year: 2017 ident: 6258_CR5 publication-title: J Biol Chem doi: 10.1074/jbc.M116.756379 – volume: 18 start-page: e1010395 year: 2022 ident: 6258_CR15 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1010395 – volume: 176 start-page: 3834 year: 2019 ident: 6258_CR7 publication-title: Br J Pharmacol doi: 10.1111/bph.14787 – volume: 353 start-page: i3077 year: 2016 ident: 6258_CR26 publication-title: Br Med J doi: 10.1136/bmj.i3077 – volume: 14 start-page: 57 year: 2014 ident: 6258_CR27 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(13)70286-X – volume: 101 start-page: 863 year: 2017 ident: 6258_CR2 publication-title: J Leukoc Biol doi: 10.1189/jlb.4MR0616-288R – volume: 9 start-page: e1003392 year: 2013 ident: 6258_CR4 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1003392 – volume: 48 start-page: 35 year: 2018 ident: 6258_CR12 publication-title: Immunity doi: 10.1016/j.immuni.2017.11.013 – volume: 6 start-page: 1294 year: 2014 ident: 6258_CR29 publication-title: Viruses doi: 10.3390/v6031294 – volume: 12 start-page: 1629 year: 2021 ident: 6258_CR28 publication-title: Virulence doi: 10.1080/21505594.2021.1939608 – volume: 374 start-page: 1076 year: 2021 ident: 6258_CR10 publication-title: Science doi: 10.1126/science.abi5934 – volume: 6 start-page: e17618 year: 2011 ident: 6258_CR33 publication-title: PLoS ONE doi: 10.1371/journal.pone.0017618 – volume: 591 start-page: 131 year: 2021 ident: 6258_CR36 publication-title: Nature doi: 10.1038/s41586-021-03218-7 – volume: 21 start-page: 67 year: 2021 ident: 6258_CR1 publication-title: Nat Rev Immunol doi: 10.1038/s41577-021-00498-y – volume: 84 start-page: 7569 year: 2010 ident: 6258_CR21 publication-title: J Virol doi: 10.1128/JVI.00291-10 – volume: 522 start-page: 102 year: 2015 ident: 6258_CR24 publication-title: Nature doi: 10.1038/nature14348 – volume: 92 start-page: e00396 year: 2018 ident: 6258_CR32 publication-title: J Virol doi: 10.1128/JVI.00396-18 – volume: 12 year: 2023 ident: 6258_CR17 publication-title: Clin Trans Immunol doi: 10.1002/cti2.1443 – volume: 34 start-page: 108887 year: 2021 ident: 6258_CR37 publication-title: Cell Rep doi: 10.1016/j.celrep.2021.108887 – volume: 107 start-page: 217 year: 2013 ident: 6258_CR25 publication-title: Pathog Glob Health doi: 10.1179/2047773213Y.0000000103 – volume: 12 start-page: 401 year: 2020 ident: 6258_CR3 publication-title: Viruses doi: 10.3390/v12040401 – volume: 73 start-page: 43 year: 1941 ident: 6258_CR31 publication-title: J Exp Med doi: 10.1084/jem.73.1.43 – volume: 3 start-page: 17070 year: 2017 ident: 6258_CR35 publication-title: Cell Death Discov doi: 10.1038/cddiscovery.2017.70 – volume: 6 year: 2016 ident: 6258_CR8 publication-title: Sci Rep doi: 10.1038/srep27912 – volume: 526 start-page: 666 year: 2015 ident: 6258_CR16 publication-title: Nature doi: 10.1038/nature15541 – volume: 154 start-page: 197 year: 2013 ident: 6258_CR34 publication-title: Cell doi: 10.1016/j.cell.2013.06.013 – volume: 32 start-page: 203 year: 2020 ident: 6258_CR38 publication-title: Int Immunol doi: 10.1093/intimm/dxz070 – volume: 99 start-page: 737 year: 2021 ident: 6258_CR9 publication-title: Immunol Cell Biol doi: 10.1111/imcb.12459 – volume: 6 start-page: 128 year: 2021 ident: 6258_CR23 publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-021-00507-5 – volume: 93 start-page: 2315 year: 2012 ident: 6258_CR30 publication-title: J Gen Virol doi: 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| Title | Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection |
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