Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that basal levels of the IFN-stimulated gene 15, ISG15, and its c...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 14; číslo 1; s. 6140 - 15
Hlavní autoři:	Moro, Ramona N., Biswas, Uddipta, Kharat, Suhas S., Duzanic, Filip D., Das, Prosun, Stavrou, Maria, Raso, Maria C., Freire, Raimundo, Chaudhuri, Arnab Ray, Sharan, Shyam K., Penengo, Lorenza
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 02.10.2023 Nature Publishing Group Nature Portfolio
Témata:	631/337/151/2356 631/67/1059/2326 631/80/304 631/80/458/582 631/80/86 82/29 82/47 82/58 96/63 96/95 BRCA1 protein BRCA2 protein Breast cancer Cell proliferation Cell viability Chemotherapy Cisplatin Conjugation Defects Deoxyribonucleic acid DNA DNA biosynthesis DNA repair Drug resistance Embryo cells Genotoxicity Humanities and Social Sciences Inactivation Inflammation Interferon Lethality multidisciplinary Replication Science Science (multidisciplinary) Stability Stem cells Up-regulation β-Interferon
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!