Pancreatic Cancer: Changing Epidemiology and New Approaches to Risk Assessment, Early Detection, and Prevention

Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of preinvasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although...

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Bibliographic Details
Published in:Gastroenterology (New York, N.Y. 1943) Vol. 164; no. 5; p. 752
Main Authors: Stoffel, Elena M, Brand, Randall E, Goggins, Michael
Format: Journal Article
Language:English
Published: United States 01.04.2023
Subjects:
Early Detection of Cancer - methods
Humans
Pancreas
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - prevention & control
Risk Assessment
Risk Factors
Surveillance
Pancreatic Cancer
Genetic Susceptibility
ISSN:1528-0012, 1528-0012
Online Access:Get more information
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Summary:Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of preinvasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although screening for pancreatic cancer is currently not recommended for the general population, emerging evidence indicates that pancreatic surveillance can improve outcomes for individuals in certain high-risk groups. Changes in the epidemiology of pancreatic cancer, experience from pancreatic surveillance, and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic cancer risk assessment, early detection, and prevention.
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content type line 23
ISSN:1528-0012
1528-0012
DOI:10.1053/j.gastro.2023.02.012