Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor. To identify new genes involved in the cellular uptake of LDL, we develop...

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Veröffentlicht in:	Journal of lipid research Jg. 63; H. 1; S. 100160
Hauptverfasser:	Lucero, Diego, Dikilitas, Ozan, Mendelson, Michael M., Aligabi, Zahra, Islam, Promotto, Neufeld, Edward B., Bansal, Aruna T., Freeman, Lita A., Vaisman, Boris, Tang, Jingrong, Combs, Christian A., Li, Yuesheng, Voros, Szilard, Kullo, Iftikhar J., Remaley, Alan T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.01.2022 American Society for Biochemistry and Molecular Biology Elsevier
Schlagworte:	actin-binding protein cellular LDL uptake CRISPR-Cas Systems - genetics Endocytosis Genome-Wide Association Study Hep G2 Cells HepG2 cells Humans LDL LDL receptor Lipoproteins, LDL - metabolism Microfilament Proteins - genetics Microfilament Proteins - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Receptors, LDL - genetics Receptors, LDL - metabolism Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism transgelin whole-genome CRISPR-Cas9 screen FH TAGLN GWAS ASCVD mSREBP2 LFC HepG2 cells FACS pSREBP2 UTR transgelin LDL sTfR endocytosis CME qPCR SNV cellular LDL uptake LDLR CRISPR GTEx whole-genome CRISPR-Cas9 screen CAD PCSK LDL receptor actin-binding protein TC UKBB TG NHLBI sgRNA
ISSN:	0022-2275, 1539-7262, 1539-7262
Online-Zugang:	Volltext
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