Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides

ATP-sensitive potassium channels (K ATP ) are metabolic sensors that convert the intracellular ATP/ADP ratio to the excitability of cells. They are involved in many physiological processes and implicated in several human diseases. Here we present the cryo-EM structures of the pancreatic K ATP channe...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 2770 - 10
Main Authors:	Wang, Mengmeng, Wu, Jing-Xiang, Ding, Dian, Chen, Lei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19.05.2022 Nature Publishing Group Nature Portfolio
Subjects:	101/28 631/154/436 631/45/269/1151 631/535/1258/1259 692/699/2743/137 82/83 9/74 ABC transporters Adenosine diphosphate Adenosine triphosphate Channels Diabetes Excitability Humanities and Social Sciences Hypoglycemia Insulin Intracellular Laboratories Metabolism multidisciplinary Mutation Nucleotides Pancreas Physiology Potassium Potassium channels (inwardly-rectifying) Proteins Science Science (multidisciplinary) Sensors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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