More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

The genus comprises 65 species, among which is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally analyzed 80 genomes spanning 58 species. Uniquely, an immense repository of 18,000 secreted proteins encodin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 6; S. 2265
Hauptverfasser:	Gomez-Valero, Laura, Rusniok, Christophe, Carson, Danielle, Mondino, Sonia, Pérez-Cobas, Ana Elena, Rolando, Monica, Pasricha, Shivani, Reuter, Sandra, Demirtas, Jasmin, Crumbach, Johannes, Descorps-Declere, Stephane, Hartland, Elizabeth L, Jarraud, Sophie, Dougan, Gordon, Schroeder, Gunnar N, Frankel, Gad, Buchrieser, Carmen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.02.2019
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Secretion Systems - genetics Computational Biology - methods Evolution, Molecular Genome, Bacterial Genomics - methods Humans Intracellular Space - microbiology Legionella - classification Legionella - physiology Legionellosis - microbiology Phylogeny Protein Domains Legionella human pathogen horizontal gene transfer coevolution protozoa
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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