The impact of enteral feeding and therapeutic monitoring of rifampicin with dose escalation in critically ill patients with tuberculosis

•Rifampicin concentrations were low in all continuously fed critically ill patients.•Dose escalation increased drug exposure and achieved target concentrations.•Therapeutic drug monitoring should be implemented in critically ill patients to improve dose optimization.•Further research is required to...

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Vydané v:	International journal of infectious diseases Ročník 126; s. 174 - 180
Hlavní autori:	Perumal, Rubeshan, Naidoo, Kogieleum, Naidoo, Anushka, Letsoalo, Marothi P., Esmail, Aliasgar, Joubert, Ivan, Denti, Paolo, Wiesner, Lubbe, Padayatchi, Nesri, Maartens, Gary, Dheda, Keertan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Canada Elsevier Ltd 01.01.2023 Elsevier
Predmet:	Critical Illness Dose-adjustment Drug Monitoring Drug Therapy, Combination Enteral Nutrition High-dose rifampicin Humans Personalized medicine Pharmacokinetics Rifampin Tuberculosis - drug therapy High-dose rifampicin Critical illness Pharmacokinetics Personalized medicine Dose-adjustment
ISSN:	1201-9712, 1878-3511, 1878-3511
On-line prístup:	Získať plný text
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