Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting their efficacy in clinical trials against hematologic...

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Vydáno v:	Blood Ročník 136; číslo 10; s. 1155
Hlavní autoři:	Fultang, Livingstone, Booth, Sarah, Yogev, Orli, Martins da Costa, Barbara, Tubb, Vanessa, Panetti, Silvia, Stavrou, Victoria, Scarpa, Ugo, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Lee, Steven P, Dunn, Warwick B, Chesler, Louis, Mussai, Francis, De Santo, Carmela
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 03.09.2020
Témata:	Animals Apoptosis Arginine - metabolism Argininosuccinate Synthase - genetics Argininosuccinate Synthase - metabolism Cell Proliferation Humans Immunotherapy, Adoptive - methods Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Metabolic Engineering - methods Mice Mice, Nude Neuroblastoma - immunology Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - therapy Ornithine Carbamoyltransferase - genetics Ornithine Carbamoyltransferase - metabolism Receptors, Chimeric Antigen - chemistry Receptors, Chimeric Antigen - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - transplantation Tumor Cells, Cultured Xenograft Model Antitumor Assays
ISSN:	1528-0020, 1528-0020
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