Clinical and public health utility of Mycobacterium tuberculosis whole genome sequencing

•WGS has particular value in the diagnosis and management of TB disease.•It can give more rapid and complete information on TB drug-resistance.•The high resolution allows detection of clusters, contamination and mixed infections.•Future goals include culture free & targeted next generation seque...

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Vydáno v:International journal of infectious diseases Ročník 113; s. S40 - S42
Hlavní autoři: Kizny Gordon, Alice, Marais, Ben, Walker, Timothy M., Sintchenko, Vitali
Médium: Journal Article
Jazyk:angličtina
Vydáno: Canada Elsevier Ltd 01.12.2021
Elsevier
Témata:
COVID-19
Humans
Multidrug-resistance
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Pandemics
Public Health
SARS-CoV-2
Whole Genome Sequencing
Mycobacterium tuberculosis
Whole genome sequencing
Multidrug-resistance
ISSN:1201-9712, 1878-3511, 1878-3511
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Shrnutí:•WGS has particular value in the diagnosis and management of TB disease.•It can give more rapid and complete information on TB drug-resistance.•The high resolution allows detection of clusters, contamination and mixed infections.•Future goals include culture free & targeted next generation sequencing.•Greatest utility is antimicrobial resistance surveillance in high-burden countries. The World Health Organization (WHO) estimates that around 10 million people develop tuberculosis (TB) every year, with 1.5 million deaths attributed to TB in 2019 (World Health Organization, 2020). The majority of the disease burden occurs in low-income countries, where access to diagnostics and tailored treatment remains problematic. The current COVID-19 pandemic further threatens to impact global TB control by diverting resources, reducing notifications and hence significantly increasing deaths attributable to TB (World Health Organization, 2020). Whole genome sequencing (WGS) is becoming increasingly accessible, and has particular value in the diagnosis and management of TB disease (Cabibbe et al., 2018; Meehan et al., 2019). Not only does it have the potential to give more rapid and complete information on drug-resistance, but the high discriminatory power it offers allows detection of clusters and transmission pathways, as well as likely contamination events, mixed infections and to differentiate between re-infection and relapse with much greater confidence than previous typing methods.
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ISSN:1201-9712
1878-3511
1878-3511
DOI:10.1016/j.ijid.2021.02.114