Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets

Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and diminishing the anti-tumor response of immunotherapies. While primary and metastatic tumors are typically the focal points of therapeutic develop...

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Bibliographic Details
Published in:	Cell death discovery Vol. 7; no. 1; pp. 232 - 10
Main Authors:	DaSilva, Nicholas A., Barlock, Benjamin J., Guha, Prajna, Ghosh, Chandra C., Trebino, Catherine E., Camberg, Jodi L., Katz, Steven C., Rowley, David C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.09.2021 Springer Nature B.V Nature Publishing Group
Subjects:	631/154/555 631/250/251/1574 631/45/475 631/67/327 Apoptosis Biochemistry Biomedical and Life Sciences CD11b antigen Cell Biology Cell Cycle Analysis Drug development Hepatocytes Immunotherapy Life Sciences Liver Lung cancer Metastases Metastasis Protein interaction Proteins Proteomes Proteomics Stem Cells Suppressor cells Tumor microenvironment Tumors
ISSN:	2058-7716, 2058-7716
Online Access:	Get full text
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