Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum

We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing’s sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a co...

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Veröffentlicht in:International journal of infectious diseases Jg. 81; S. 167 - 169
Hauptverfasser: Zakham, Fathiah, Pillonel, Trestan, Brunel, Anne-Sophie, Zambelli, Pierre-Yves, Greub, Gilbert, Croxatto, Antony, Bertelli, Claire
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Canada Elsevier Ltd 01.04.2019
Elsevier
Schlagworte:
Bacterial genomics
Bone insufficiency
Clostridium ramosum
Erysipelatoclostridium ramosum
Graft resorption
Pseudoarthrosis
Taxogenomics
Pseudoarthrosis
Taxogenomics
Bone insufficiency
Graft resorption
Bacterial genomics
Clostridium ramosum
Erysipelatoclostridium ramosum
ISSN:1201-9712, 1878-3511, 1878-3511
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Zusammenfassung:We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing’s sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a context of bone insufficiency and graft resorption. A broad range 16S PCR followed by sequencing, as well as an enrichment culture of a bone biopsy revealed the presence of E. ramosum, an anaerobic firmicute with a low Gram-positive affinity staining and low GC content, that was further characterized by whole genome sequencing (WGS).
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1201-9712
1878-3511
1878-3511
DOI:10.1016/j.ijid.2019.02.001