The Role of Traditional and Reverse Algorithms in the Diagnosis of Syphilis in HIV-Infected Individuals: A Case Study on Istanbul

Background/Objectives: T. pallidum subsp. pallidum is a spirochete that only causes disease in humans as the causative agent of syphilis. HIV and syphilis have common transmission routes. In the present study, our aim was to evaluate the presence of syphilis coinfection in people living with HIV usi...

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Vydáno v:Diagnostics (Basel) Ročník 15; číslo 3; s. 365
Hlavní autoři: Yapar, Gizem, Köksal, Muammer Osman, Sarsar, Kutay, Soğuksu, Pınar, Demirci, Mehmet, Yurtseven, Eray, Kır, Murat Hakan, Allahverdiyeva, Aytaj, Çağatay, Arif Atahan, Ağaçfidan, Ali, Kırkoyun Uysal, Hayriye
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.02.2025
MDPI
Témata:
Algorithms
Antibodies
Case studies
Congenital diseases
COVID-19
Development and progression
Disease transmission
Health aspects
HIV
HIV (Viruses)
HIV infection
HIV patients
HIV testing
Homosexuality
Human immunodeficiency virus
Immunology
Infection
Infections
Infectious diseases
Laboratories
Lymphocytes
Medical diagnosis
Medical research
Medicine, Experimental
RNA
Serology
Sexually transmitted diseases
Software
STD
Syphilis
syphilis diagnostic algorithms
Young adults
Turkey
Istanbul Turkey
United States > US
Spain
sexually transmitted diseases
syphilis
HIV
syphilis diagnostic algorithms
ISSN:2075-4418, 2075-4418
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Shrnutí:Background/Objectives: T. pallidum subsp. pallidum is a spirochete that only causes disease in humans as the causative agent of syphilis. HIV and syphilis have common transmission routes. In the present study, our aim was to evaluate the presence of syphilis coinfection in people living with HIV using conventional and reverse algorithms and to investigate its effects on laboratory parameters. Methods: The traditional algorithm for syphilis begins testing with the non-treponemal test. If the non-treponemal test is reactive, a treponemal test is then used to confirm syphilis infection. The reverse algorithm for syphilis begins testing with the treponemal test. If this test is reactive, then a non-treponemal test is performed. When the non-treponemal test is non-reactive, a second treponemal test is performed. Results: A total of 200 patients were included in the study. While 22 patients were determined to be syphilis-positive using the traditional algorithm, 37 patients were determined to be syphilis-positive using the reverse algorithm. Most of the patients who had syphilis coinfection were homosexual. Conclusions: It was found that syphilis coinfection had no effects on CD4+ T-lymphocyte and CD8+ T-lymphocyte values, CD4/CD8 rates, and HIV RNA amounts. People living with HIV must be screened and followed up for syphilis and other sexually transmitted diseases at certain intervals.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics15030365