Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease

Patients with perianal fistulizing Crohn's disease have a poor prognosis because these lesions do not heal well. We evaluated the effects of local administration of bone marrow-derived mesenchymal stromal cells (MSCs) to these patients from healthy donors in a double-blind, placebo-controlled s...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 149; no. 4; pp. 918 - 27.e6
Main Authors:	Molendijk, Ilse, Bonsing, Bert A, Roelofs, Helene, Peeters, Koen C M J, Wasser, Martin N J M, Dijkstra, Gerard, van der Woude, C Janneke, Duijvestein, Marjolijn, Veenendaal, Roeland A, Zwaginga, Jaap-Jan, Verspaget, Hein W, Fibbe, Willem E, van der Meulen-de Jong, Andrea E, Hommes, Daniel W
Format:	Journal Article
Language:	English
Published:	United States 01.10.2015
Subjects:	Adult Bone Marrow Transplantation - adverse effects Cells, Cultured Crohn Disease - complications Crohn Disease - diagnosis Double-Blind Method Female Humans Magnetic Resonance Imaging Male Mesenchymal Stem Cell Transplantation - adverse effects Middle Aged Netherlands Rectal Fistula - diagnosis Rectal Fistula - etiology Rectal Fistula - surgery Time Factors Transplantation, Homologous Treatment Outcome Wound Healing Young Adult Netherlands Treatment Cell Therapy Inflammatory Bowel Disease Perianal Fistulas
ISSN:	1528-0012
Online Access:	Get more information
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