TLR or NOD receptor signaling skews monocyte fate decision via distinct mechanisms driven by mTOR and miR-155

Monocytes are rapidly recruited to inflamed tissues where they differentiate into monocyte-derived macrophages (mo-mac) or dendritic cells (mo-DC). At infection sites, monocytes encounter a broad range of microbial motifs. How pathogen recognition impacts monocyte fate decision is unclear. Here, we...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 118; H. 43
Hauptverfasser:	Coillard, Alice, Guyonnet, Léa, De Juan, Alba, Cros, Adeline, Segura, Elodie
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 26.10.2021
Schlagworte:	Humans Signal Transduction Toll-Like Receptors - metabolism TOR Serine-Threonine Kinases macrophage monocyte pathogen dendritic cell
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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