Mechanisms of resistance to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown unprecedented clinical activity in several types of cancer and are rapidly transforming the practice of medical oncology. Whereas cytotoxic chemotherapy and small molecule inhibitors ('targeted therapies'...

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Veröffentlicht in:	British journal of cancer Jg. 118; H. 1; S. 9
Hauptverfasser:	Jenkins, Russell W, Barbie, David A, Flaherty, Keith T
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.01.2018
Schlagworte:	Animals Biomarkers Cancer Chemotherapy CTLA-4 protein Cytotoxicity Drug Resistance, Neoplasm Humans Immune checkpoint inhibitors Immune response Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Immunotherapy Lymphocytes T Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - immunology PD-1 protein PD-L1 protein Signal Transduction - drug effects T-Lymphocytes - drug effects Tumors
ISSN:	0007-0920, 1532-1827, 1532-1827
Online-Zugang:	Volltext
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