Identification of biomarkers for tuberculosis disease using a novel dual-color RT–MLPA assay

Owing to our lack of understanding of the factors that constitute protective immunity during natural infection with Mycobacterium tuberculosis ( Mtb ), there is an urgent need to identify host biomarkers that predict long-term outcome of infection in the absence of therapy. Moreover, the identificat...

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Veröffentlicht in:	Genes and immunity Jg. 13; H. 1; S. 71 - 82
Hauptverfasser:	Joosten, S A, Goeman, J J, Sutherland, J S, Opmeer, L, de Boer, K G, Jacobsen, M, Kaufmann, S H E, Finos, L, Magis-Escurra, C, Ota, M O C, Ottenhoff, T H M, Haks, M C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.01.2012 Nature Publishing Group
Schlagworte:	Adaptive immunity Apoptosis Biological markers Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Cohort analysis Diagnosis Gene Expression Gene Expression Profiling Genes Genetic Markers - genetics Human Genetics Humans Identification Immune response Immune system Immunology Infections Infectious diseases Latent infection Lymphocytes B Lymphocytes T Mycobacterium tuberculosis Nucleic Acid Amplification Techniques - methods original-article Physiological aspects Polymerase chain reaction Real-Time Polymerase Chain Reaction - methods Reproducibility of Results Sensitivity and Specificity Transcriptomics Tuberculosis Tuberculosis - genetics Tuberculosis - immunology Vaccines Netherlands Gambia dcRT–MLPA tuberculosis host biomarkers
ISSN:	1466-4879, 1476-5470, 1476-5470
Online-Zugang:	Volltext
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