Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

Reduced postprandial muscle proteolysis is mainly due to increased insulin availability. Whether rates of proteolysis in response to low physiologic doses of insulin are affected by aging is unknown. We tested the hypothesis that suppression of leg protein breakdown (LPB) by insulin is blunted in ol...

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Vydáno v:	The American journal of clinical nutrition Ročník 90; číslo 5; s. 1343
Hlavní autoři:	Wilkes, Emilie A, Selby, Anna L, Atherton, Philip J, Patel, Rekha, Rankin, Debbie, Smith, Ken, Rennie, Michael J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.11.2009
Témata:	Adult Aged Aging - physiology Amino Acids - blood Amino Acids - metabolism Female Glucose Clamp Technique Humans Insulin - blood Insulin - pharmacology Leg Leucine - metabolism Male Muscle Proteins - drug effects Muscle Proteins - metabolism Muscular Diseases - prevention & control Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism
ISSN:	1938-3207, 1938-3207
On-line přístup:	Zjistit podrobnosti o přístupu
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