Serum levels of perfluoroalkyl substances (PFAS) and body composition – A cross-sectional study in a middle-aged population

It has been suggested that per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with a potential to influence fat mass. The primary hypothesis tested was that we would find positive relationships for PFAS vs measures of adiposity. In 321 subjects all aged 50 years in the POEM study, f...

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Vydané v:Environmental research Ročník 209; s. 112677
Hlavní autori: Lind, P. Monica, Lind, Lars, Salihovic, Samira, Ahlström, Håkan, Michaelsson, Karl, Kullberg, Joel, Strand, Robin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier Inc 01.06.2022
Predmet:
adiposity
Alkanesulfonic Acids
blood serum
Body Composition
Computerized Image Processing
Cross-Sectional Studies
Datoriserad bildbehandling
dual-energy X-ray absorptiometry
Environmental Pollutants
Fat
Female
Fluorocarbons
Humans
Imiomics
lipid content
liver
Magnetic Resonance Imaging
magnetism
Male
Middle Aged
muscles
Per- and polyfluoroalkyl substances (PFAS)
perfluorohexane sulfonic acid
perfluorononanoic acid
perfluorooctane sulfonic acid
perfluorooctanoic acid
pericardium
statistical analysis
subcutaneous fat
visceral fat
Whole Body Imaging
Whole-body-MRI
Whole-body-MRI
Fat
Per- and polyfluoroalkyl substances (PFAS)
Body composition
Imiomics
ISSN:0013-9351, 1096-0953, 1096-0953
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Shrnutí:It has been suggested that per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with a potential to influence fat mass. The primary hypothesis tested was that we would find positive relationships for PFAS vs measures of adiposity. In 321 subjects all aged 50 years in the POEM study, five PFAS (perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA)) were measured in serum together with a Dual-energy X-ray absorptiometry (DXA) scan for determination of fat and lean mass. Whole-body magnetic resonance imaging scan was performed and the body was divided into >1 million voxels. Voxel-wise statistical analysis was carried out by a novel method denoted Imiomics. PFOS and PFHxS, did not show any consistent associations with body composition. However, PFOA, and especially PFNA and PFDA, levels were inversely related to most traditional measures reflecting the amount of fat in women, but not in men. In the Imiomics analysis of tissue volume, PFDA and PFNA levels were inversely related to the volume of subcutaneous fat, mainly in the arm, trunk and hip regions in women, while no such clear relationship was seen in men. Also, the visceral fat content of the liver, the pericardium, and the gluteus muscle were inversely related to PFDA and PFNA in women. Contrary to our hypothesis, some PFAS showed inverse relationships vs measurements of adiposity. PFOS and PFHxS levels in plasma did not show any consistent associations with body composition, but PFOA, and especially PFNA and PFDA were inversely related to multiple measures reflecting the amount of fat, but in women only. •Traditional body composition was evaluated by X-ray (DXA) and magnetic resonance imaging (MRI).•Also a voxel-wise analysis of MRI images were performed; imiomics.•PFOS and PFHxS levels were not consistently related to body composition.•PFOA, and especially PFNA and PFDA, were inversely related to fat mass measurements.•These relationships for PFOA, PFNA and PFDA were only seen in women.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0013-9351
1096-0953
1096-0953
DOI:10.1016/j.envres.2022.112677