Treatment-Associated Neuroplastic Changes in People with Stroke-Associated Ataxia—An fMRI Study

Background/Objectives: In consideration of the significance of the pursuit of training-induced neuroplastic changes in the stroke population, who are reliant on neurorehabilitation treatment for the restoration of neuronal function, the objectives of this trial were to investigate fMRI paradigms for...

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Vydáno v:Neurology international Ročník 17; číslo 6; s. 84
Hlavní autoři: Meier, Patricia, Siedentopf, Christian, Mayer-Suess, Lukas, Knoflach, Michael, Kiechl, Stefan, Schönherr, Gudrun Sylvest, Grams, Astrid E., Gizewski, Elke R., Lamina, Claudia, Galijasevic, Malik, Steiger, Ruth
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 29.05.2025
MDPI
Témata:
acute stroke
Ataxia
Balance
Clinical trials
coordination exercises
Gait
Learning
Neuroplasticity
neurorehabilitation
Physical therapy
plasticity
Quality of life
Stroke
Austria
Germany
fMRI
acute stroke
ataxia
balance
coordination exercises
motor imagery
plasticity
foot tapping
neurorehabilitation
ISSN:2035-8377, 2035-8385, 2035-8377
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Shrnutí:Background/Objectives: In consideration of the significance of the pursuit of training-induced neuroplastic changes in the stroke population, who are reliant on neurorehabilitation treatment for the restoration of neuronal function, the objectives of this trial were to investigate fMRI paradigms for acute stroke patients with ataxic symptoms, to follow up on changes in motor function and balance due to recovery and rehabilitation, and to investigate the different effects of two treatment methods on neuronal plasticity. Methods: Therefore, fMRI-paradigms foot tapping and the motor imagery (MI) of a balancing task (tandem walking) were employed. Results: The paradigms investigated were suitable for ataxic stroke patients to monitor changes in neuroplasticity while revealing increased activity in the primary motor cortex (M1) and the cerebellum over 3 months of treatment. Furthermore, analysis of the more complex balance task revealed augmented activation of association areas due to training. Coordination exercises, constituting a specific treatment of ataxic symptoms, indicate more consolidated brain activations, corresponding to a faster motor learning process. Activation within Brodmann Area 7 has been prominent among all paradigms, indicating a special importance of this region for coordinative functions. Conclusions: Further studies are needed to confirm our results in larger patient groups. Clinical Trial Registration: German Clinical Trials Registry (drks.de). Identifier: DRKS00020825. Registered 16.07.2020.
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These authors contributed equally to this work.
ISSN:2035-8377
2035-8385
2035-8377
DOI:10.3390/neurolint17060084