Low Skeletal Muscle Mass and the Incidence of Delirium in Hospitalized Older Patients: A Systematic Review and Meta-Analysis of Observational Studies

Background. Both low skeletal muscle mass and delirium are prevalent in older hospitalized patients, while their associations are unclear. This systematic review and meta-analysis aim to investigate the associations between low skeletal muscle mass and the incidence of delirium in hospitalized patie...

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Vydáno v:International journal of clinical practice (Esher) Ročník 2023; s. 1 - 9
Hlavní autoři: Shen, Yuhou, Wan, Qianyi, Zhao, Rui, Chen, Yi, Xia, Lin, Wu, Yutao, Xiao, Shuomeng, Wang, Yong, Zhao, Lihao, Li, Tao, Wu, Xiaoting
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Hindawi 2023
John Wiley & Sons, Inc
Wiley
Témata:
Age
Back surgery
Bias
Cancer
Cohort analysis
Cross-sectional studies
Delirium
Delirium - epidemiology
Delirium - etiology
Females
Hospitalization
Humans
Incidence
Magnetic resonance imaging
Meta-analysis
Muscle, Skeletal
Musculoskeletal system
Observational studies
Odds Ratio
Review
Risk Factors
Sarcopenia
Sensitivity analysis
Skeletal muscle
Surgery
Systematic review
Tomography
Italy
Netherlands
ISSN:1368-5031, 1742-1241, 1742-1241
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Shrnutí:Background. Both low skeletal muscle mass and delirium are prevalent in older hospitalized patients, while their associations are unclear. This systematic review and meta-analysis aim to investigate the associations between low skeletal muscle mass and the incidence of delirium in hospitalized patients. Methods. The PubMed, Web of Science, and Embase were searched for relevant studies published before May 2022, and we conducted this systematic review and meta-analysis according to the PRISMA and MOOSE guidelines. The summary odds ratios (OR) and 95% confidence intervals (CI) were estimated, and subgroup analyses were also conducted according to the age and major surgeries. Results. Finally, nine studies with 3 828 patients were included. The pooled result showed no significant association between low skeletal muscle mass and the incidence of delirium (OR 1.69, 95% CI 0.85 to 2.52). However, sensitivity analysis suggested that one study caused a significant alteration of the summary result, and the meta-analysis of the remaining 8 studies showed that low skeletal muscle mass was significantly associated with an 88% increased incidence of delirium (OR 1.88, 95% CI 1.43 to 2.33). Furthermore, subgroup analyses indicated that low skeletal muscle mass was associated with a higher incidence of delirium in patients ≥75 years old or undergoing major surgeries instead of those <75 years old or without surgeries, respectively. Conclusions. Hospitalized patients with low skeletal muscle mass might have higher incidence of delirium, particularly in those of older age and undergoing major surgeries. Therefore, great attention should be paid to these patients.
Bibliografie:ObjectType-Article-2
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ObjectType-Evidence Based Healthcare-1
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Academic Editor: Aderito Seixas
ISSN:1368-5031
1742-1241
1742-1241
DOI:10.1155/2023/4098212