Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway

Abnormal dendritic cell differentiation and accumulation of immunosuppressive myeloid cells in cancer is one of the major factors of tumor nonresponsiveness. We have previously shown that hyperactivation of the Janus-activated kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 65; H. 20; S. 9525
Hauptverfasser:	Nefedova, Yulia, Nagaraj, Srinivas, Rosenbauer, Amsler, Muro-Cacho, Carlos, Sebti, Said M, Gabrilovich, Dmitry I
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.10.2005
Schlagworte:	Animals CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Cell Differentiation - immunology Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - therapy Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Epitopes, T-Lymphocyte - immunology Female Immunotherapy, Adoptive - methods Janus Kinase 2 Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Myeloid Cells - cytology Myeloid Cells - drug effects Myeloid Cells - immunology NIH 3T3 Cells Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Sarcoma, Experimental - drug therapy Sarcoma, Experimental - immunology Sarcoma, Experimental - therapy Signal Transduction - drug effects Signal Transduction - immunology STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Triterpenes - pharmacology
ISSN:	0008-5472
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