Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program

Exercise intervention has been proven helpful to ameliorate core symptoms of Autism Spectrum Disorder (ASD). However, the underlying mechanisms are not fully understood. In this study, we carried out a 12-week mini-basketball training program (MBTP) on ASD children and examined the changes of brain...

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Veröffentlicht in:Journal of autism and developmental disorders Jg. 54; H. 12; S. 4515 - 4528
Hauptverfasser: Zhou, Dongyue, Liu, Zhimei, Gong, Guanyu, Zhang, Yunge, Lin, Lin, Cai, Kelong, Xu, Huashuai, Cong, Fengyu, Li, Huanjie, Chen, Aiguo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Springer US 01.12.2024
Springer
Springer Nature B.V
Schlagworte:
Autism
Autism Spectrum Disorder - diagnostic imaging
Autism Spectrum Disorder - physiopathology
Autism Spectrum Disorder - rehabilitation
Autism Spectrum Disorder - therapy
Autism Spectrum Disorders
Autistic children
Basketball
Behavioral Science and Psychology
Brain
Brain - diagnostic imaging
Brain - physiopathology
Brain architecture
Changes
Child
Child and School Psychology
Child, Preschool
Children
China
Control Groups
Exercise Therapy - methods
Female
Functional anatomy
Functional connectivity
Functional magnetic resonance imaging
Health aspects
Humans
Intervention
Magnetic Resonance Imaging
Male
Morphology
Networks
Neural networks
Neuroanatomy
Neurosciences
Original Paper
Pediatric research
Pediatrics
Pervasive developmental disorders
Physiological aspects
Psychological aspects
Psychology
Public Health
Resting
Salience
Sensorimotor system
Social aspects
Structure-function relationships
Symptoms
Temporal gyrus
Training
China
Functional connectivity
K-means
Autism spectrum disorder (ASD)
Morphological brain network
Exercise intervention
ISSN:0162-3257, 1573-3432, 1573-3432
Online-Zugang:Volltext
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Zusammenfassung:Exercise intervention has been proven helpful to ameliorate core symptoms of Autism Spectrum Disorder (ASD). However, the underlying mechanisms are not fully understood. In this study, we carried out a 12-week mini-basketball training program (MBTP) on ASD children and examined the changes of brain functional and structural networks before and after exercise intervention. We applied individual-based method to construct functional network and structural morphological network, and investigated their alterations following MBTP as well as their associations with the change in core symptom. Structural MRI and resting-state functional MRI data were obtained from 58 ASD children aged 3–12 years (experiment group: n = 32, control group: n = 26). ASD children who received MBTP intervention showed several distinguishable alternations compared to the control without special intervention. These included decreased functional connectivity within the sensorimotor network (SM) and between SM and the salience network, decreased morphological connectivity strength in a cortical-cortical network centered on the left inferior temporal gyrus, and a subcortical–cortical network centered on the left caudate. Particularly, the aforementioned functional and structural changes induced by MBTP were associated with core symptoms of ASD. Our findings suggested that MBTP intervention could be an effective approach to improve core symptoms in ASD children, decrease connectivity in both structure and function networks, and may drive the brain change towards normal-like neuroanatomy.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0162-3257
1573-3432
1573-3432
DOI:10.1007/s10803-023-06160-x