A case of methotrexate‐associated Epstein‐Barr virus‐positive mucocutaneous ulcer

Epstein‐Barr virus‐positive mucocutaneous ulcer (EBVMCU) is a B‐cell proliferative disorder that has been designated as a provisional entity in the 2017 World Health Organization classification for lymphoid neoplasms. While EBVMCU may contain varying numbers of cells with Hodgkin and Reed‐Sternberg...

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Bibliographic Details
Published in:Skin Health and Disease Vol. 2; no. 2; pp. e108 - n/a
Main Authors: Sakamoto, Keiko, Baba, Takeshi, Takatori, Hiroaki, Nagao, Keisuke, Misawa, Junko, Honda, Tetsuya
Format: Journal Article
Language:English
Published: England Wiley 01.06.2022
Oxford University Press
John Wiley and Sons Inc
Subjects:
Antigens
Bacterial infections
Biopsy
Case Report
Case Reports
Conflicts of interest
Dermatology
Editing
Epstein-Barr virus
Histology
Lymphocytes
Lymphoma
Rheumatoid arthritis
RL1-803
Supervision
Ulcers
Writing
ISSN:2690-442X, 2690-442X
Online Access:Get full text
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Summary:Epstein‐Barr virus‐positive mucocutaneous ulcer (EBVMCU) is a B‐cell proliferative disorder that has been designated as a provisional entity in the 2017 World Health Organization classification for lymphoid neoplasms. While EBVMCU may contain varying numbers of cells with Hodgkin and Reed‐Sternberg cells‐like morphology, the clinical course is benign and must be distinguished from lymphomas. Patients who develop EBVMCU are commonly immunocompromised, with methotrexate (MTX) as the leading cause. Most previously reported cases of EBVMCU describe mucosal ulcers with very little documentation on skin lesions and its course. Here, we report a case of MTX‐associated EBVMCU of the lower leg that underwent spontaneous regression after MTX withdrawal, during which negative conversion of local Epstein‐Barr virus activation was confirmed.
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ISSN:2690-442X
2690-442X
DOI:10.1002/ski2.108